Latest technologies from Rutgers the State University of New Jerseyhttp://rutgers.technologypublisher.comBe the first to know about the latest inventions and technologies available from Rutgers, The State University of New Jerseyen-USSun, 19 May 2019 17:40:58 GMTTue, 30 Apr 2019 13:54:47 GMT 2019, Rutgers the State University of New JerseyA Method for Large Scale Production of Collagen-like Proteins in Bacteria Summary:Collagens are the major structural proteins in the extracellular matrix of animals and are defined by a characteristic triple-helix structure that requires a (Gly-Xaa-Yaa)n repeating sequence. Collagen is widely used in the cosmetic, medical, and manufacturing industries. Currently, most collagens are derived from animal sources. There has been a growing concern of transmissible diseases from animal to humans. Moreover, current technology cannot standardize the extraction procedures and is still unable to make sequence modifications that could improve or modulate biological p...Tue, 30 Apr 2019 13:54:47 GMTchristopher.perkins@rutgers.edu Transmission Potentially Enabling Secret Communications, 22 Apr 2019 12:55:04 GMTchristopher.perkins@rutgers.edu Resistant Glass-Ceramic, 22 Apr 2019 12:42:10 GMTchristopher.perkins@rutgers.edu Fabrication of Pristine Holey Graphene Nanoplatelet catalyst, pristine holey graphene can convert Nitrobenzene to Azobenzene (grey bar) with 100% selectivity by 100% conversion (blue bar)Invention Summary:Rutgers Researchers have developed a novel and scalable approach to fabricate pristine holey graphene nanoplatelets with nearly free of defects and metal resides via microwave irritation. The hole edges can be controlled to be rich in zigzag geometry, which is the preferred structure for catalytic and electronic applications. The main workhorse in developing various industrial important chemical catalytic and electronic applications relies ...Mon, 22 Apr 2019 12:30:34 GMTchristopher.perkins@rutgers.edu Receptor Antagonists – Non-Addictive Pain Management Summary:The Sigma-1 receptor (S1R) is a ligand-gated molecular chaperone protein, found in the endoplasmic reticulum and plasma membranes, which modulates mu-opioid and NMDA receptors. S1R antagonists can reduce the amplification of messages coming from pain sensors without impacting non-pain sensors that transmit other types of stimuli. Rutgers researchers have developed a new class of compounds, with the lead molecule named PW507, that exhibit: (1) potent S1R binding affinity and antagonism, (2) high selectivity for S1R over S2R, (3) favorable in vitro and in vivo metabolic stabili...Mon, 22 Apr 2019 12:06:11 GMTchristopher.perkins@rutgers.edu Resistant to Eastern Filbert Blight Summary: Rutgers University initiated a hazelnut research and breeding program in 1996 to address the fatal tree disease eastern filbert blight (EFB) caused by the naturally occurring fungus, Anisogramma anomala.Rutgers made large seed collections across Eastern Europe, the Caucuses, and Central Asia to cross and breed the collected trees for eastern US trials. The program spans over 20 years as of 2019, and Rutgers now has 25,000 trees on 20 acres in various stages of evaluation.About 2% of trees were discovered to have some resistance. Utilizing these, advanced breeding lines were ...Thu, 11 Apr 2019 10:01:00 GMTchristopher.perkins@rutgers.edu Alignment and Insertion of Percutaneous Cannulating Instruments Device prototype. (Right) Short-axis ultrasound image of segmented vessel for insertion.Invention Summary: Gaining access to blood vessels is a critical first step in a plethora of diagnostic and therapeutic procedures (see market applications). The timely delivery of these interventions can affect morbidity and mortality, yet in difficult conditions, access can be highly challenging. Difficulties are exacerbated in patients with small, tortuous, or collapsed vessels, which are common in pediatric, elderly, chronically-ill, traumatic, and hypovolemic patients. Poorly introduced needles ...Fri, 05 Apr 2019 12:41:14 GMTchristopher.perkins@rutgers.edu New Type of Catalyst for Direct Electrochemical CO2 Reduction To Hydrocarbons, 05 Apr 2019 12:32:28 GMTchristopher.perkins@rutgers.edu Barcoding of Microparticles for Multiplexed Molecular Analysis Summary: Capability of detecting multiple protein and nucleic acid biomarkers is crucial to disease diagnosis and precision medicine. Barcoding of microparticles is one of the most common approaches for enabling multiplexed molecular assays. Although optical and plasmonic methods for barcoding particles have been developed, instrumentations involved are often bulky and expansive, preventing portability. Dr. Javanmard at Rutgers University has developed a novel system for portable, multiplexing biosensing applications. The multiplexing capability is achieved through the use of a newly...Thu, 04 Apr 2019 11:50:12 GMTchristopher.perkins@rutgers.edu Glass-Ceramic Composite, 01 Apr 2019 08:07:05 GMTchristopher.perkins@rutgers.edu Technique to Grow Low Defect Single Crystalline Thin Films Summary: Rutgers Researchers have developed a method to grow a large scale of high quality single crystalline In2Se3 thin film using a temporal seed of Bi2Se3. This technology can be used in fabricating high quality In2Se3-incorporated devices, such as low-defect-density Bi2Se3, an archetypical 3D topological insulator. Interfacial and bulk defects have remained the major obstacles for further progress in the field of topological insulators (TI) since their discovery. To realize the functional TI devices for application in quantum computer and spintronics, a defect-suppressed TI thin...Mon, 01 Apr 2019 07:52:26 GMTchristopher.perkins@rutgers.edu Injectable and Long-Acting Local Anesthetics Summary: Local anesthetics prevent or relieve pain by interrupting nerve conduction. Even the long-acting local anesthetic agents (e.g., bupivacaine, levobupivacaine, ropivacaine) can only provide analgesia for 4-18 hours. Because of the short duration, local anesthetics often have to be given by repeated injection or continuous infusion. The inventors here developed an injectable PLGA-coated ropivacaine, which has a dose-dependent, reversible, and long-lasting analgesic effect on post-operative pain and neuropathic pain. The maximal duration of this composition's analgesia at 0.25% ...Mon, 01 Apr 2019 07:43:27 GMTchristopher.perkins@rutgers.edu ZnO and its Nanostructure -Based 1T1R and 1D1R Switching Matrices for Reconfigurable Electronics and Optoelectronics, 18 Mar 2019 08:35:16 GMTchristopher.perkins@rutgers.edu Targeted Gene Therapy for Treatment of LAMA2-Related Muscular Dystrophy, 13 Mar 2019 13:38:58 GMTchristopher.perkins@rutgers.edu and ADC Derivatives of Non-Camptothecin TOP1-Targeting Cancer Chemotherapeutics, 13 Mar 2019 13:14:39 GMTchristopher.perkins@rutgers.edu Antibacterial Compounds for Oral Care of CAM reduction in bacterial attachment to hydroxyapatite-coated surfaces relative to control with 100% attachment (i.e. 0% reduction)Invention Summary:Periodontitis and caries are common oral diseases caused by enamel demineralization due to bacterial adhesion to teeth. Introducing a layer to the surface of teeth can inhibit bacterial adhesion and prevent these oral ailments. Water-soluble, acid-stable, linear polymers are commonly used in oral care products to prevent bacterial attachment to teeth. However, current products are not efficiently adsorbed on teeth enamel. Rutgers resear...Fri, 08 Mar 2019 12:41:07 GMTchristopher.perkins@rutgers.edu GH for Improved Glycan Polymer Synthesis Summary: Oligosaccharides and polysaccharides (or glycans) are complex macromolecules in living systems that serve critical structural and functional roles. In vitro synthesis of these complex biomolecules is very challenging. Glycosytransferases are naturally available enzymes that catalyze the synthesis of glycans, but have poor expression yield, narrow substrate specificity, and use expensive nucleotide sugars. Rutgers scientists have engineered a multifunctional family 5 glycosyl hydrolase (GH-5 called CelE) from Clostridium thermocellum into a transglycosidase to synthesize dive...Wed, 06 Mar 2019 08:37:00 GMTchristopher.perkins@rutgers.edu Stackable Tissue Culture Platform for 3D Co-Culture Summary: In a native tissue inside an animal, different types of cells co-exist and communicate with one another through the surrounding microenvironment using chemical and mechanical signaling. The lack of technology to recreate such a microenvironment in in vitro models results in either under or over prediction of results using conventional two-dimensional (2D) in vitro cell culture systems. Researchers at Rutgers have developed a simple device for 3D co-culture. Unlike conventional tissue culture inserts for co-culturing cell types in two or three separate compartments, this devi...Wed, 06 Mar 2019 08:30:11 GMTchristopher.perkins@rutgers.edu Decisions of Algorithms Using Examples, 26 Feb 2019 10:30:32 GMTchristopher.perkins@rutgers.edu Discovery of Information, 26 Feb 2019 09:45:38 GMTchristopher.perkins@rutgers.edu Catalyst for Dehydrogenative Dimerization of Ethylene to Yield 1,3-Butadiene diagram of the catalytic dehydrogenative dimerization of ethylene to butadieneInvention Summary: 1,3-Butadiene is a chemical building block, most notably known for the production of synthetic elastomers and polymers. Traditionally, 1,3-butadiene is produced as a byproduct of naphtha cracking for ethylene production. Due to new sources, ethylene production has shifted away from naphtha cracking towards cracking ethane-rich shale gas. This has a left an unmet demand for 1,3-butadiene.Researchers at Rutgers University developed a new method of producing 1,3-butadiene using a phebox pinc...Thu, 21 Feb 2019 18:57:43 GMTchristopher.perkins@rutgers.edu Physical Vetting of 3D Prints with Minimal Embedded Nano-Material Assessor of the Model SystemInvention Summary:3D printing has become highly desirable in industrial manufacturing and biomedical applications. Outsourcing the manufacturing to a 3D printing facility leaves the user without access to the printers and a lack of physical verification to determine whether small defects, invisible to the naked eye, have been inserted. Like other automated systems, there is a need for safety parameters and end-user verification.Researchers at Rutgers University and Georgia Tech developed a method for physical verification of 3D printed structures. This method allows...Thu, 21 Feb 2019 18:39:46 GMTchristopher.perkins@rutgers.edu Therapy to Treat Spinal Cord Injury SCI mice showed significant functional recoveryInvention Summary:Spinal cord injury (SCI) results in permanent disruption to nervous system function. There is no effective treatment to promote recovery of motor function after spinal cord injury currently available on the market. Previous research for SCI treatment was focused on targeting either cell source (new neurons) for damage repair or glial scar (inhibition of astrogliosis) for axon regrowth. Although these efforts have laid important ground work in the field, translation to clinical practice has been limited due to the lack of ...Tue, 12 Feb 2019 14:04:46 GMTchristopher.perkins@rutgers.edu Novel One-handed Cannulation Device Summary:Intravenous cannulation is routinely performed to provide reliable central venous access for administration of medical therapy. The conventional Seldinger cannulation technique is the mainstay of central line placement, however, it can lead to complications due to multiple steps and the need of changing multiple moving parts with two hands. The most critical steps of the Seldinger technique involves the removal of the syringe while holding the needle tip in place and inserting a guide wire into the vessel via the inner bore of the needle.Dr. Ehsani-Nia at Robert Wood Johnson ...Tue, 12 Feb 2019 11:53:20 GMTchristopher.perkins@rutgers.edu LOW-PHASE-NOISE OSCILLATOR, 28 Jan 2019 11:01:53 GMTchristopher.perkins@rutgers.edu Delivery of Solid Insecticide Summary: Mosquito borne diseases constitute more than half a billion illnesses and over a million deaths yearly. Wide-scale mosquito pesticide and larvicide dispersion (e.g., aerial dispersion) is no longer a viable option due to 1) posing public health concerns, and 2) urban area expansion into mosquito habitats, making mosquito control untenable. Hence, targeted delivery of mosquito control payloads to inaccessible areas should be used to avoid environmental contamination and adverse human effects. Rutgers researchers have developed a new mechanism for the targeted delivery of soli...Fri, 25 Jan 2019 11:35:14 GMTchristopher.perkins@rutgers.edu Lubricant Additives for Improving Engine Efficiency and Fuel Economy, 24 Jan 2019 08:28:22 GMTchristopher.perkins@rutgers.edu Method of Aggregating Environmental DNA for of terrestrial eDNA is achieved by: (1) Sampling of spatially distributed eDNA (2) A strategy to aggregate species-specific samples (3) Concentration of target eDNA (4) Extraction of eDNA and testingInvention Summary: Earlyrecognition and rapid eradication of exotic species can prevent detrimental ecological or economic effects. However, in terrestrial systems, this approach is often limited by the difficulty of detecting the invasive species early, while its population numbers are still low. To address this challenge, scientists at Rutgers have developed a method for surveilling ...Wed, 23 Jan 2019 14:07:19 GMTchristopher.perkins@rutgers.edu Nanomaterial for Prolonged and Sustained Antibacterial Efficacy BAC release profile at pH 4.0, 5.0, 6.5, and 7.4. b) The percentage of S. aureus survival upon exposure to BAC loaded nanoparticles after 0, 3, and 6 hours.Invention Summary: Quaternary ammonium cationic (QAC) surfactants are one of the preferred choices for antibacterial applications. The compounds are water and oil soluble, and they cover a broad spectrum of antimicrobial efficacy including gram-positive and gram-negative contaminations. In applications such as bandages and surgical dressings, extended release of active compounds would be beneficial and desirable.Researchers at Rutgers Un...Fri, 18 Jan 2019 11:00:53 GMTchristopher.perkins@rutgers.edu Information Flow Tracking for Mobile, Wearable, and IOT Sensor Devices Summary:Mobile devices have a variety of sensors that enable a wide range of useful applications from step tracking to point of care medical services. In addition, sensors are now in automobiles, IoT and other devices. As the use of devices with sensors increase, it becomes important that information from theses sensors does not leak to outside parties. Researchers at Rutgers university and UCLA have designed a novel Information Flow Tracking (IFT) technique and software, called METRON, that implements a value-based tracking solution to detect potential data leaks from apps on mobile...Fri, 18 Jan 2019 07:02:50 GMTchristopher.perkins@rutgers.edu Array for High Density Integration with Low Crosstalk, 14 Jan 2019 12:24:54 GMTchristopher.perkins@rutgers.edu for Sintering Ultrahigh Melting Temperature Covalent Non-oxide Ceramics, 14 Jan 2019 12:22:55 GMTchristopher.perkins@rutgers.edu Novel, Tailor-Made MOF for Exceptionally Efficient Separation of Propane and Propylene Summary: Separating mixtures of propane and propylene is often challenging and energy intensive. In industrial settings this separation is typically performed by cryogenic distillation, requiring low temperature and/or pressure. Metal-organic frameworks (MOFs) are emerging as promising low-energy alternatives to energy-intensive distillations, as their performance is often comparable to industrial benchmarks with a reduced energetic cost. Researchers at Rutgers University have developed a novel MOF for efficient separation of propylene and propane by size-selective exclusion. The mat...Thu, 06 Dec 2018 09:21:51 GMTchristopher.perkins@rutgers.edu Antibody for the Early Detection of Pancreatic Cancer staining of mAb Das-1 against low-risk IPMN (left) and high-risk IPMN (right). Gut. 2014 Oct; 63(10):1626-34; 15(11):1009-16Invention Summary:Pancreatic cancer accounts for 5% of all cancer deaths. Early stages of pancreatic cancer are often asymptomatic. As a result, patients with pancreatic cancer are often diagnosed after the cancer is very advanced, and the 5-year survival rate of the patients is less than 6%. Lots of patients can be saved by early detection and treatment of the precursor lesions of pancreatic cancer, including intraductal papillary mucinous neoplasms (IPM...Thu, 06 Dec 2018 09:05:26 GMTchristopher.perkins@rutgers.edu Method to Determine Number of Contributors in a DNA Mixture, 03 Dec 2018 07:52:23 GMTchristopher.perkins@rutgers.edu Controlling Access to Network File Systems, 28 Nov 2018 13:22:11 GMTchristopher.perkins@rutgers.edu High Voltage Thin Film Transistor for Self-powered Wearable Electronics mounted on a platform for bending testInvention Summary: Wearable systems have been emerging for broad applications. One of the major technical challenges for the technology is its power management. The self-powered wearable electronics which aim to provide users continuous, non-interrupted, and hassle-free experiences are highly desired. However, current self-powered technology faces 3 challenges: (1) unstable due to the environment variations; (2) requirement of an external bulky power management component, and (3) built on the rigid substrate.To address these issues, a research team...Wed, 28 Nov 2018 13:03:36 GMTchristopher.perkins@rutgers.edu Analytics the distribution plots of price by score (descending)The Problem: Data scientists take an enormous mass of messy data points (unstructured and structured) and use math, statistics and programming to clean, massage and organize them. Then they apply analytic expertise (e.g. industry knowledge, contextual understanding, skepticism of existing assumptions) to uncover hidden solutions to business challenges. This process of uncovering hidden patterns visualized as plots, takes a tremendous amount of programming, that is often quite repetitive and tedious. As a result. companies need to hire h...Mon, 26 Nov 2018 12:31:41 GMTchristopher.perkins@rutgers.edu of Field Performance in Woody Perennials via Drought Resistant Genes and Nitrogen Use Efficiency, 01 Nov 2018 10:54:07 GMTchristopher.perkins@rutgers.edu of Microscale Coatings by Self-Limiting Electrospray Overview of thickness-limited electrospray deposition (ESD). Electrostatically-driven spray creates a charged film which redirects charged incident droplets. b. and c. SEM images of spray results, illustrating the wide range of morphologies and particle size which can be obtained with this method(b: nanowires, c: hollow spheres).Invention Summary: Researchers at Rutgers University have developed a scalable, cost-effective method for depositing microscale coatings of a wide variety of materials and composites compatible with complex additive manufactured or micromachined structures. The newl...Fri, 19 Oct 2018 07:06:24 GMTchristopher.perkins@rutgers.edu Zirconium-Based Metal-Organic Frameworks for Efficient Separation of C6 Alkane Isomers, 19 Oct 2018 06:52:19 GMTchristopher.perkins@rutgers.edu Vitro Model of Liver Steatosis for Screening of Drug Compounds decrease in liver steatosis in hepatocytes cultured in steatosis reducing medium.Invention Summary: Donor livers are frequently rejected due to high intracellular fat content, called steatosis, which increases the risk of primary graft non-function in transplant patients. Because liver transplantation remains the only effective treatment for end-stage liver disease, the inability to use steatotic livers significantly contributes to the worldwide donor liver shortage. Though several compounds have been identified for their potential to de-fatten steatotic livers, there is a need for further...Wed, 19 Sep 2018 08:50:26 GMTchristopher.perkins@rutgers.edu Molecular Trap for Capturing Radioactive Organic Iodides from Nuclear Waste, 19 Sep 2018 08:40:46 GMTchristopher.perkins@rutgers.edu Metal-Organic Framework for Temperature-Programmable Molecular Sieving of Linear, Mono and Dibranched Alkane Isomers representation of the proposed separation of C6 alkane isomers.Invention Summary: Separating mixtures of hydrocarbons with comparable boiling points is often challenging and energy intensive. Adsorptive separation of hydrocarbons is commonly used as a low-energy alternative to industrial distillations. Recently, however, metal-organic frameworks (MOFs) are emerging as promising alternatives to traditional adsorptive solids. Currently, however, there are no adsorptive compounds which permit efficient discrimination between alkane isomers exhibiting different degrees of branching. Rese...Tue, 11 Sep 2018 07:07:54 GMTchristopher.perkins@rutgers.edu Methods for Enhanced Efficacy of Mesenchymal Stem Cells, 30 Aug 2018 11:44:35 GMTchristopher.perkins@rutgers.edu Circuit Building Blocks for SOG and Wearable Electronics Summary:Advanced information technology, such as emerging internet of things (IoT) is facing increasing needs for systems-on-demand capable of task and defect adaptation in real-time at lower cost. High-performance electronic systems combing the state-of-the-art processing logics, memories, and sensors on a single chip is highly desired. The challenge in implementing reconfigurable switching matrix network that can be integrated with various functional subsystems, such as advanced displays and wearable electronics requiring high density, high performance, low power consumption, and l...Wed, 29 Aug 2018 11:39:37 GMTchristopher.perkins@rutgers.edu SILICONE FOAM FOR THE SELECTIVE ABSORPTION OF OIL FROM WATER Summary: Large oil spills (over 100,000 tons) such as the BP Deepwater Horizon spill (in which $20B was spent on cleanup and litigation) are not very frequent. However, in 2011 there were over 10 oil spills that released between 15 to 5,500 tons of oil into water. When an oil spill disaster occurs, oil quickly spreads on the surface of water and thus makes the cleanup an extremely difficult operation. The negative environmental impacts of oil spills are severe and current products and techniques do not provide an adequate solution. Researchers at Rutgers have developed a new absorben...Wed, 29 Aug 2018 11:29:31 GMTchristopher.perkins@rutgers.edu Supplement and Feed Compositions to Reduce the Incidence of Osteochondrosis Dissecans Lesions in Genetically Predisposed Foals dietary supplement formulation was developed based on an analysis of serum NMR data from yearling Standardbred horses with (green dots) and without (blue dots) OCD that showed the clear difference in metabolic profiles between genetically predisposed and unaffected horses.Invention Summary:Rutgers scientists and collaborators at Princeton University have developed a new dietary supplement specifically formulated to reduce the incidence of Osteochondrosis Dissecans (OCD) in genetically predisposed young horses. The dietary supplement was developed based on the results of nuclear magnetic re...Wed, 29 Aug 2018 11:29:28 GMTchristopher.perkins@rutgers.edu and Versatile Copolymers to Promote Wound Healing Summary:Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise for promoting topical and surgical wound healing, as SA is known to reduce local pain and inflammation as well as potentially prevent fibrous adhesion formation by reducing scar tissue. The release is stable over a period of around 10 days, which is the critical window for fibrous adhesion formation. The novel formulation is achieved by copolymerization of salicylic acid-based poly(anhydride-esters) (SAPAE) with poly(ethylene glycol) (PEG). The copolymer with ...Wed, 29 Aug 2018 11:29:23 GMTchristopher.perkins@rutgers.edu, Mineral-based Polymers with Ionic Crosslinks ionomers show characteristic behavior of polymers, including fiber formation (left) and flow (center). However, they have high thermal stability: like silicate glass (top right), inorganic ionomers (bottom right) they do not burn or produce fumes when exposed to flame.Invention Summary:Traditional, carbon-based, organic polymers have many applications, but they rely on petroleum, a limited resource. Additionally, carbon-based polymers have low thermal stability and often release harmful chemicals when they break down.Researchers at Rutgers have developed polymers with inorganic backb...Wed, 29 Aug 2018 11:29:17 GMTchristopher.perkins@rutgers.edu System for High-Yield Production of Proteins and Protein Domains, 29 Aug 2018 11:29:12 GMTchristopher.perkins@rutgers.edu Terrain Modeling Diagnostics Software (RTMDx), 29 Aug 2018 11:29:06 GMTchristopher.perkins@rutgers.edu Indentation Method Using Scanning Probe Microscope Summary:Accurate indentation measurement is fundamental to atomic force microscope (AFM)-based material property characterization as the force applied and the indentation generated are the two most important physical variables that must be measured in the characterization process. Large measurement errors occur when the measurement frequency range becomes large (i.e., broadband), or the indentation is measured in liquid on soft materials. Such large measurement errors are generated due to the inability of the conventional method to account for the convolution of the AFM instrument dy...Wed, 29 Aug 2018 11:29:05 GMTchristopher.perkins@rutgers.edu Dual Racetrack Silicon Micro-resonators for Quadrature Amplitude Modulation, 29 Aug 2018 11:28:55 GMTchristopher.perkins@rutgers.edu Rare Earth-Based Biophotonic Composites, 29 Aug 2018 11:28:43 GMTchristopher.perkins@rutgers.edu PLATFORM GAP BRIDGING UNIT Summary:In a recent report sponsored by the New Jersey Department of Transportation, it was found that car/platform gap injuries accounted for 25% of all injuries on NJ TRANSIT Rail lines, including death. Similar findings have been reported by other agencies, including the Long Island Rail Road and the Metropolitan Transit Agency of New York. These results prompted the Federal Railroad Safety Advisory Committee to address the seriousness of the car/platform gap issue. Researchers at Rutgers University have developed an apparatus that dynamically fills the gap between the door sill o...Wed, 29 Aug 2018 11:28:40 GMTchristopher.perkins@rutgers.edu Differential Pump for Oxide Molecular Beam Epitaxy Summary:Flux instability of the evaporation sources is one of the biggest problems in the multi-elemental oxide Molecular Beam Epitaxy techniques. Source oxidation of easily oxidizing elements such as Ca, Sr, Ba, and Ti in an oxidizing ambient leads to their flux instability. Such unstable flux rate is detrimental to precise control of film thickness and composition. The only way to prevent this source reaction from happening is to suppress the pressure of the reactive gas near the evaporation source while maintaining high enough gas pressure near the substrate where the film grows w...Wed, 29 Aug 2018 11:28:34 GMTchristopher.perkins@rutgers.edu Nanoparticle-Based Biosensor for Biomarker Detection and Its Use in Early Diagnosis of Cancer, HIV and Other Diseases SchematicInvention Summary:The detection of biomarker proteins with high sensitivity and selectivity is vital for the early diagnosis of many diseases such as cancer and HIV. Rutgers scientists have developed a reduced graphene oxide encapsulated nanoparticle (rGO-NPs)-based field effect transistor (FET) biosensor for sensitive detection of key disease biomarker proteins including cancer markers. This invention is a FET with a source electrode and a drain electrode distanced apart from each other on a semiconductor substrate, and a gate electrode consisting of a uniform layer of rGO-NPs...Wed, 29 Aug 2018 11:28:28 GMTchristopher.perkins@rutgers.edu ZnO Thin Film Transistor Biosensor with High Sensitivity and Selectivity and selective detection of EGFR in serum. (a) Drain current vs. gate bias plot. (b) Sensitivity plot of the device for pure EGFR and EGFR in serum detection. (c) Sensor schematic.Invention Summary:Various semiconductor devices have been developed for use as biosensors including Ion Sensitive Field Effect Transistors (ISFETs), Organic Field Effect Transistors (OFETs), and nanowire-based FET sensors. However, all of these FET-based devices have drawbacks ranging from high bias voltage, low mobility, low output current, low sensitivity, to complex fabrication processes. Zinc Oxide (ZnO)...Wed, 29 Aug 2018 11:28:24 GMTchristopher.perkins@rutgers.edu<![CDATA[Scalable Multiple Inverse-Diffusion Flame Synthesis of Graphene, Syngas and Liquid Fuel & Fabrication of Diamond-Reinforced Composites]]> A schematic multiple inverse-diffusion flames burner. B) Raman spectrum of the few-layer graphene (FLG) on Ni. C) HRTEM image of the FLG. The bottom right insert shows the electron diffraction pattern of the graphene sheet. The top left insert shows resolution magnified image of the graphitic lattice. Invention Summary:Carbon-based nanostructures and films define a new class of engineered materials that display remarkable physical, photonic and electronic properties. Production methods for making carbon-based nanostructures include ultrahigh vacuum annealing of SiC, and chemical vapor depos...Wed, 29 Aug 2018 11:28:14 GMTchristopher.perkins@rutgers.edu for producing jet fuel from food and non-food feedstocks Summary:A number of separate studies have shown that genome-scale flux-balance analysis (FBA) modeling can be useful for the in silico design of engineered strains of microbes that overproduce diverse targets. These engineered strains include Escherichia coli (E. coli) that overproduce lycopene, lactic acid, succinic acid, l-valine, l-threonine, and strains of Saccharomyces cerevisiae that overproduce ethanol. FBA models allow the result of various genetic manipulations strategies to be predicted. As a result, the space of possible genetic manipulations can be computationally searche...Wed, 29 Aug 2018 11:28:09 GMTchristopher.perkins@rutgers.edu Collagen Methacrylamide-Derivatized Hydrogels Summary:Natural material collagen has the benefits of bioactivity, biodegradability, and innate adhesiveness and self-assemble, which allows the material to be injected into a defect of almost any geometry with minimal invasion, and then automatically become a solid to provide a stable matrix but have the limited control of mechanical properties. Rutgers scientist Dr. David Shreiber invented a process for creating type I collagen and methacrylamide (CMA)-based hydrogel, which retains the properties of collagen such as self-assembly, biodegradability, and natural bioactivity. In addit...Wed, 29 Aug 2018 11:28:05 GMTchristopher.perkins@rutgers.edu FLOW ANALYSIS FOR CARDIOVASCULAR DIAGNOSTICS Summary:Following a heart attack or the development of some cardiovascular diseases, the movement of the heart walls during the cardiac cycle may change, which affects the motion of blood through the heart. Currently, valvular blood flow can be monitored using imaging techniques such as Doppler ultrasound or time-series MRI, however, the spatial resolutions of such techniques are poor. In addition, it is not possible to observe the detailed interaction of the blood flow and the endocardial surface of the heart. Therefore, the formation of cardiac thrombus remains difficult to predict...Wed, 29 Aug 2018 11:28:01 GMTchristopher.perkins@rutgers.edu Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases Combined nanocarrier based targeted chemo and gene therapy1. Cellular penetration of naked siRNA (green) and siRNA delivered by nanocarrier (red), 2. Treatment of mice bearing metastatic ovarian cancer. a. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (before treatment), b. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (after treatment).Invention Summary:Rutgers scientists have developed an ovarian tumor-targeted therapeutic delivery system that utilizes a nanocarrier delivery vehicle such as liposome or dendrime...Wed, 29 Aug 2018 11:27:55 GMTchristopher.perkins@rutgers.edu Surface Probes and Quantitative Recognition Arrays, 29 Aug 2018 11:27:51 GMTchristopher.perkins@rutgers.edu Catalysts for Water Oxidation/Water Splitting compounds like LiCo2O4 catalyzes water oxidation at lower over-potental than industry standards (Ir, Ru, Pt, Pd) . The crystal structure determines the electro-catalytic performance, with other structures (layered, cubic) or compositions (AB2O4) more useful at different current densitiesInvention Summary: Development of water oxidation/ oxygen reduction catalysts to replace costly and inefficient platinum group metals in commercial electrolyzers and fuel cells has been an unmet need preventing global development of hydrogen technologies. Researchers at Rutgers University have developed ...Wed, 29 Aug 2018 11:27:43 GMTchristopher.perkins@rutgers.edu and Manufacture of Pharmaceuticals by Impregnation onto Porous Carriers, 29 Aug 2018 11:27:34 GMTchristopher.perkins@rutgers.edu Agents from Leaves of Combretum micranthum (Kinkeliba) 40 and 80 min. following oral glucose challenge, the TPFA treated group had significantly lowered plasma glucose concentrations compared to the control group.Invention Summary:Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum (kinkeliba) and a procedure for the preparation of total piperidine flavan alkaloids (TPFA) that possess anti-diabetic properties.Kinkeliba is a highly regarded medicinal plant in Africa, with roots, bark, fruit and leaves being used. In its native Sub-S...Wed, 29 Aug 2018 11:27:32 GMTchristopher.perkins@rutgers.edu With Controllable Size And Morphology, 29 Aug 2018 11:27:21 GMTchristopher.perkins@rutgers.edu Enriched Black Tea Extract to Increase Physical Performance and Reduce Recovery Time from Intense Exercise had higher average power and peak power of 9 repeated sprint intervals in the black tea extract (BTE) supplementation group as compared to the placebo (no BTE supplementation) group (PLA).Invention Summary: Rutgers scientists have identified a new, high-potency black tea extract composition that enhances physical performance. This composition contains a physiologically acceptable carrier and a ployphenol-enriched tea extract. Human clinical trials involving supplementation with the enriched black tea extract found increased baseline antioxidant status, improved hypothalamic-pituitary-...Wed, 29 Aug 2018 11:26:58 GMTchristopher.perkins@rutgers.edu Vehicle Information Systems and Methods sensor fitted on the side of a car detects parked cars and vacant spaces.Invention Summary:ParkNet is a mobile system comprising vehicles that collect parking space occupancy information while driving by. Each ParkNet vehicle is equipped with a GPS receiver and a passenger-side-facing ultrasonic rangefinder to determine parking spot occupancy. The data is aggregated at a central server, which builds a real-time map of parking availability and could provide this information to clients that query the system in search of parking. Creating a spot-accurate map of parking availability cha...Wed, 29 Aug 2018 11:26:56 GMTchristopher.perkins@rutgers.edu of Kombo Butter Extract and Derived Compounds as Novel Neuroprotective Agents, 29 Aug 2018 11:26:50 GMTchristopher.perkins@rutgers.edu Luminescent Microporous Materials for Fast and Reversible Detection of Trace Vapor of High Explosives Summary:Investigators at Rutgers University have synthesized a microporous material made of metal (Zn) and organic molecules with strong capabilities for detecting trace vapor of high explosives. The highly luminescent material exhibits very fast response and high sensitivity towards nitroaromatic explosive DNT, and plastic explosive taggant, DMNB. Such materials lay the groundwork for developing highly sensitive and highly selective luminescent MMOF-based sensors and sensor arrays. Market Application:Explosive detectionPublic and national securityEnvironmental protectionAdvantages:L...Wed, 29 Aug 2018 11:26:49 GMTchristopher.perkins@rutgers.edu Brightness Excimer Lamp, 29 Aug 2018 11:26:18 GMTchristopher.perkins@rutgers.edu Zinc Oxide Nanotips with Transparent Conductive Film for Photovoltaic Devices Summary:Researchers at Rutgers University have invented a novel 3-D structure by integrating Zinc Oxide (ZnO) nanotips and ZnO transparent conductive oxide (TCO) film for applications in photovoltaic devices. This novel 3-D structure has multifunctionality with in-situ doping: the ZnO film is heavily doped, acting as the transparent and conductive electrode, while the undoped or less heavily doped single crystalline ZnO nanotips provide n-type semiconductor with nanostructure morphology, acting for anchoring dye and/or polymer molecules. The ZnO nanotips and ZnO TCO film can be grown...Wed, 29 Aug 2018 11:25:42 GMTchristopher.perkins@rutgers.edu, High-strength, Low-Temperature Cure, High-Temperature Resistant Composite Summary:Ceramic composites are popular in applications where materials are expected to encounter high temperatures, i.e. engine components, exhaust systems, and fire barriers. The low density as compared to metals makes them attractive in applications where weight is a critical design parameter. However, most ceramic composites are fabricated using high heat treatment and the operating temperatures are often lower than the temperatures used for the fabrication of the composites. In addition, the production of high-temperature resistant ceramic composites typically involves the use of...Wed, 29 Aug 2018 11:25:29 GMTchristopher.perkins@rutgers.edu RE-doped SiO2-base Fluorescent Materials image showing nano-silicate formation in a glassy matrix, after annealing at 1000 oC for 24 hoursInvention Summary:A new class of nanostructured RE-doped SiO2-base materials that display superior fluorescence properties with high gain combined with a broad and flat spectral band with. Such enhanced fluorescence properties have been observed in heat treated nanopowders prepared by vapor-phase, sol-gel and spray-pyrolysis methods. The expectation is that similar effects will be observed in monolithic materials, when known bulk glass processing methods, such as glass-ceramic processing, inc...Wed, 29 Aug 2018 11:24:04 GMTchristopher.perkins@rutgers.edu Butter Extract and Derivatives as Novel Anti-Inflammatory Agents Summary:Rutgers scientists have developed a novel process to isolate the critical bio-active compounds of Kombo butter, which can be used to effectively treat a variety of inflammatory disorders including arthritis/joint or other inflammation (including bowels, gastrointestinal, skin, and allergic), and the presence of associated free radicals. Kombo butter (African nutmeg) has been shown to have various health benefits as a food or diet supplement, with multiple purported benefits. Our scientists have isolated the 3 key functional chemicals critical to anti-inflammatory action of Ko...Wed, 29 Aug 2018 11:23:35 GMTchristopher.perkins@rutgers.edu Agents from Artemisia Plants Summary:Rutgers scientists have discovered that extracts of Artemisia plants, in particular Artemisia dracunculus, could be useful for treating Type 2 diabetes. These extracts can be rapidly and inexpensively obtained in a concentrated form (e.g., powder) by extraction using common mildly polar solvents (e.g., ethanol). Numerous recent publications from the Rutgers team and colleagues at Pennington Biomedical Research Center (Lousiana State University) demonstrated that Russian tarragon (A. dracunculus) extracts modulate blood glucose levels and enzyme/receptor activities involved in...Wed, 29 Aug 2018 11:22:29 GMTchristopher.perkins@rutgers.edu Thermostable Alpha-Galactosidase for Use as a Flatulence-Reducing Agent, 29 Aug 2018 11:19:55 GMTchristopher.perkins@rutgers.edu Toothbrush with Evacuation Technology for Oral Care Summary:This invention provides a unique multi-purpose power toothbrush integrating high-vacuum functionality into a battery powered toothbrush, providing for effective removal of saliva, debris, and fluids during brushing. The removal of these potentially harmful and infectious materials aids in the prevention of pneumonia and other respiratory diseases caused by oral bacteria (e.g., Streptococcus mutans); which can be caused or exacerbated by particulate matter aspiration (references available).The device can provide crucial health and convenience benefits for disabled, susceptible...Wed, 29 Aug 2018 07:45:44 GMTchristopher.perkins@rutgers.edu Efficiency, Reduced Cost, Freezing Technologies Using Biogenic Ice Nucleation Proteins, 29 Aug 2018 07:00:16 GMTchristopher.perkins@rutgers.edu and Extracts Thereof as Anti-HCV Inhibitors Summary:Hepatitis C Virus (HCV) is an RNA virus causing persistent liver infections that can progress to chronic hepatitis, cirrhosis, and in some cases cancer of the liver. With an estimated 170-200 million people infected with HCV worldwide, HCV infection has become a major public health concern both in developed and developing countries. Current therapies against HCV with their adverse side effects, are not only expensive and limited in efficacy against the various HCV genotypes, but also give rise to mutant viruses. Therefore, there is an urgent need for developing improved antiv...Wed, 01 Aug 2018 12:41:19 GMTchristopher.perkins@rutgers.edu Laser-Based Radiocarbon Analysis System Diagram of Laboratory Radiocarbon analyzerInvention Summary: Drug metabolism studies require highly sensitive radiocarbon (C14) detection. Accelerator mass spectrometry (AMS) is a gold standard method for drug metabolism and related studies, but the high cost, low speed, complexity and large footprint of AMS instruments prohibits on-site testing. While liquid scintillation counters have a more compact footprint, they do not provide the necessary sensitivity for many drug studies. Researchers at Rutgers have developed a low-cost, benchtop, laser-based system for quantification of C14. Usi...Tue, 24 Jul 2018 13:34:28 GMTchristopher.perkins@rutgers.edu Culture Scale-Up via 3D Bioactive Microcapsule, 24 Jul 2018 13:26:57 GMTchristopher.perkins@rutgers.edu Reprogramming via Co-culture Bioreactor Summary: Co-culture systems are a popular method for engineering complex multicellular systems. Specifically, for cell therapy, where one cell population can help differentiate another therapeutic cell population. Current co-culture methods have shown benefits, though there still remains a need for a scalable, integrated system that can maintain cell viability and phenotype with downstream ease of purification of differentiated therapeutic cells. Researchers at Rutgers University developed a scalable hollow-fiber bioreactor system for co-culturing two cell types in a continuous flow ...Tue, 24 Jul 2018 13:19:45 GMTchristopher.perkins@rutgers.edu Poly(ethylene glycol)-based Vaginal Hydrogel for HIV Transmission Prevention of the primary bacterial vaginosis pathogen Gardnerella vaginalis on hydrogel with entrapped antimicrobial agent subtilosin (A) or pH lowering agent lactic acid (B).Invention Summary: Rutgers scientists have developed a polyethylene glycol (PEG) based vaginal hydrogel that can restore the natural microbicidal vaginal barrier functionality and could help prevent HIV transmission. The hydrogel is rapidly formed in-situ that allows maximal mucosal coverage and vaginal dispersion. The exceptional viscosity, elasticity and mechanical strength make this hydrogel superior to any current market...Tue, 24 Jul 2018 12:31:52 GMTchristopher.perkins@rutgers.edu Monodisperse PEGtide Dendrons as Nanocarrier for Drug Delivery Structure of PEGtideInvention Summary: Dentrimers and dendrons have generated tremendous interest as nanocarriers for various drug delivery applications. Rutgers scientists have developed a series of novel monodisperse PEGtide dendrons with versatility to accommodate various drug delivery demands.PEGtide dendrons containing alternating discrete poly (ethylene glycol) (dPEG) and amino acid/peptide moieties defines a new family of dendrons with significantly improved safety, biocompatibility and purity compared to its peers. A tunable interior void size that can reaches 200nm enab...Tue, 24 Jul 2018 12:02:21 GMTchristopher.perkins@rutgers.edu Spray-On Hydrogel as Wound Dressing and Drug Delivery Agent Summary: Hydrogel-based wound dressing is an accepted clinical practice for the promotion of wound healing and/or drug delivery. However, current hydrogel-based technologies have disadvantages including difficulty in removal, prone to gelling during packaging or storage, and requiring temperature manipulation before administration. Rutgers scientists have developed a novel and easy to use hydrogel wound dressing that gels in-situ immediately upon the mixture of two solution systems. This hydrogel can be administered by a spray and has a unique feature of reversibility, which enables ...Tue, 24 Jul 2018 11:45:22 GMTchristopher.perkins@rutgers.edu Nanodevices for Point-of-Care Testing nanodevice can detect 0.1 nm microRNAInvention Summary: Point-of-Care (POC) testing is defined as a simple operated, easy-to-read, rapid and low-cost medical diagnosis that can be used by non-specialists at home, in the field or on an ambulance. It provides timely diagnostic results, enabling early diagnosis of diseases, protective therapy and rapid treatment of the patients. POC testing requires unique features, including: (1) a simplified operation (e.g. one-pot assay) by non-specialists at diverse locations, (2) easy-to-read signals, (3) a reliable and rapid assay and (4) low cost.This ...Mon, 09 Jul 2018 06:23:08 GMTchristopher.perkins@rutgers.edu and Efficient Production of High Lysine and High Methionine Quality Protein Maize, 05 Jul 2018 08:57:15 GMTchristopher.perkins@rutgers.edu Transcutaneous Microsensor for Continuous “in situ” Monitoring of Biomarkers, 20 Jun 2018 07:38:53 GMTchristopher.perkins@rutgers.edu Hybrid Organic-Inorganic Scaffold for Drug Delivery and Stem Cell Differentiation diagram representing the self assembly of Laminin (ECM) and the MnO2 sheetInvention Summary: While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation. Researchers at Rutgers University developed a biodegradable manganese oxide-polymer hybrid scaffold designed to selectively guide stem cell differentiation while acting as a controlled drug delivery system. The biodegradable manganese oxide layer allows for drug loading and provides ...Fri, 01 Jun 2018 08:14:31 GMTchristopher.perkins@rutgers.edu Hybrid Scaffold for Stem Cell Differentiation diagram of the graphene-nanofiber hybrid scaffold, from fabrication to cell differentiation.Invention Summary: Stem cell regenerative medicine has been a promising approach to tissue restoration and cell based therapies. However, there are challenges in transplantation survival and mimicking the complexity of the cellular microenvironment. This challenge is especially present in central nervous system regenerative medicine where there is poor selectivity in the differentiation of oligodendrocytes. Researchers at Rutgers University developed a graphene-polymer hybrid scaffold designed...Fri, 01 Jun 2018 07:42:37 GMTchristopher.perkins@rutgers.edu Candidate for the Treatment of Dilated Cardiomyopathy Summary: Dilated cardiomyopathy (DCM) is the most common cause of heart failure. About 5.7 million adults in the United States have heart failure, and approximately half million new cases are diagnosed annually. Patients with DCM can lead to arrhythmias, and about half of people who develop heart failure die within 5 years of diagnosis. Current treatments for DCM are focused on symptom relief. There is a need for new drug to improve the heart condition and to treat arrhythmias and myocardial fibrosis of DCM patients. This invention provides a method to promote angiogenesis (formation...Thu, 17 May 2018 08:52:22 GMTchristopher.perkins@rutgers.edu Watermarking for Physical Authentication Summary: Physical watermarks such as raised seals and standard watermark labels enable the authentication of important financial and legal documents, identification cards and art work. Many of the known methods like using barcodes, infrared inks and standard watermarks can be easily copied or reverse engineered. Hence, there is a demand for authentication tools that are uncommon, difficult to copy or reverse engineer. Researchers from Rutgers University have developed a transparent watermark imaging device. The device makes use of multiview imaging for measuring the reflectance over ...Wed, 09 May 2018 11:33:04 GMTchristopher.perkins@rutgers.edu Signaling Inhibitors for the Treatment of Cancer, 07 May 2018 07:19:07 GMTchristopher.perkins@rutgers.edu for Neuropsychiatric Disorders by Intravitreal Injection of DREADD Followed by Eye Drops or Pills Containing DREADD agonist 1. DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like behavior as measured by the forced swim test (FST). Abbreviations: chronic dark rearing (DD); chronic dark rearing with a control virus expressed in retinal cells (DD-GFP); DREADD receptors-mediated activation of retinal cells during chronic...Mon, 07 May 2018 06:52:29 GMTchristopher.perkins@rutgers.edu Biosensors for Real-Time Antimicrobial Susceptibility Testing, 02 May 2018 09:17:40 GMTchristopher.perkins@rutgers.edu Nanosheets-Based Electrochemical Actuator, Scanning electron microscope image of restacked 1T phase 2D MoS2 film. b, The electrochemical system consists of a working electrode (the actuator) along with a counter electrode (Pt) and a reference electrode (standard calomel electrode, SCE) submerged in 0.5 M H2SO4. c, Images of curvature induced by charge intercalation in free-standing (that is, no Kapton beam) 1T MoS2 film on gold (scale bar, 1 cm). d, e, Diagram (d) and photograph (e) of actuation in forward and backward directions by modulation of the electrode potential between -0.3 V and + 0.3 V.Invention Summary: Actuators that co...Wed, 18 Apr 2018 06:53:00 GMTchristopher.perkins@rutgers.edu Zeta Potential Prediction of Protein Structures Summary: Determining the stability of drug molecules or proteins in suspension is key to designing an effective therapeutic. Zeta potential was previously only estimated from experimental data. The data characterizes the interface of a molecule and its surrounding system giving the effective charge energy and ultimately, the stability of charged molecules dispersed. Researchers at Rutgers University developed a computational software for calculating zeta potential from molecular structures, reducing the cost and time for experimentation. By simulating the molecule and its conformatio...Tue, 17 Apr 2018 07:15:59 GMTchristopher.perkins@rutgers.edu Molecule Fluorescent Probe of detection method with ROC, comparison of NIR probe with conventionalInvention Summary: Fluorophores in the near infrared (NIR) range, where body tissue is transparent, are promising alternatives to radioactive labels. Conjugation of NIR dyes to targeting agents enables specific detection of molecules of interest. However, conventional NIR probes are bulky, resulting in interference with the activity of the targeting molecule and limited cell uptake. In response to these challenges, Rutgers researchers have developed a small, DDAO-derived, near infrared fluorophore that can be co...Tue, 17 Apr 2018 06:45:51 GMTchristopher.perkins@rutgers.edu Molecular Assays for Fungal Infections of real-time NASBA assay for fungi. B: pan-Candida probe, C: pan-Aspergillus probeInvention Summary: Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. However, the current standard of care for diagnosis is blood culture, a method limited by the time to diagnosis (1-2 days), frequency of false negatives, and the difficulty in culturing certain fungi. The emergence of drug-resistant fungi adds an additional obstacle to effective treatment. While molecular assays have enabled rapid, sensitive diagnosis of bacterial and viral ...Tue, 17 Apr 2018 06:21:07 GMTchristopher.perkins@rutgers.edu Detection of Fungal Pathogens infected intrastromally with three different strains of Aspergillus (A. fumigatus, A. flavus, A. niger). Labeling of infected area using caspofungin-conjugated fluorescent probe.Invention Summary: Diagnostic imaging could provide important spatial information about fungal infections, but current imaging modalities lack specificity for fungal pathogens. Imaging in the near infrared (NIR) range, where body tissue is transparent, is particularly promising, but conventional NIR probes are to large to enter cells and access fungal pathogens. In response to these challenges, Rutgers researchers...Mon, 16 Apr 2018 12:44:08 GMTchristopher.perkins@rutgers.edu Assays for Identification of Echinocandin Resistant Fungi melting profiles for C. Glabrata after amplification of clinical isolates A) FKS1 HS1 primers B) FKS2 HS1 primers. DNA sequencing was used to confirm predicted genotypes (indicated by markers)Invention Summary:Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. Echinocandin antifungal drugs are fist-line therapy for infections due to Candida species, but the emergence of drug-resistant fungi during therapy limits the ability of physicians to effectively treat fungal infections. Rutgers researchers have developed PCR prime...Mon, 16 Apr 2018 11:48:52 GMTchristopher.perkins@rutgers.edu for Therapeutic Drug Monitoring of Fungal Drugs, 16 Apr 2018 10:57:21 GMTchristopher.perkins@rutgers.edu Sheet Folding Machine with Microfolding Technology Summary:Folded materials are useful in packaging, sandwich structures, floor boards, car bumpers and other applications where requirements pertaining to shock, vibration, energy absorption, and/or a high strength-to-weight ratio including volume reduction must be met. Folding flat sheets of material into intricate three-dimensional structures may provide a new technology for production of cores and sandwich structures. Currentproduction methods such as stretch-drawing, forging, pressing, casting and fabrication may appear to produce cosmetically similar patterns but the mechanical pr...Tue, 03 Apr 2018 08:10:00 GMTchristopher.perkins@rutgers.edu Biodegradable, Bioactive-Based Polymers for Topical, Cosmetic and Personal Care Applications Structure of salicylic acid-based polymer and its degradation products. B. Polymer degradation rates with different linker molecules. C. Free ferulic acid in aqueous solution is unstable and turns brown after 10 days (left). Ferulic acid-based polymers are stable and aesthetically more pleasing in solution under the same condition (right).Invention Summary: Rutgers scientists have developed a class of biodegradable and biocompatible polymers that chemically incorporate bioactive molecules, such as antioxidants and antimicrobials, in the backbone of the polymers for sustained release. Many c...Thu, 29 Mar 2018 12:01:01 GMTchristopher.perkins@rutgers.edu Bronchodilator Therapy for Asthma, Chronic Obstructive Pulmonary Disease and Cystic Fibrosis by Gα12 Inhibitors and Rho Inhibitors, 27 Mar 2018 10:36:51 GMTchristopher.perkins@rutgers.edu<![CDATA[Detection, Diagnosis, & Prediction of Dental Periapical Diseases Using Image Processing Techniques (Digital pixel intensity software/technology)]]> pixels allow determination of issues, location, courses of treatment, progression.Invention Summary:Incorrect diagnosis of periapical lesions may lead to either progression of the disease of unnecessary surgical procedures.This new method and adapted software provides DIFFERENTIAL DIAGNOSIS, EARLY DETECTION and information not obtainable via visual (eyeball) inspection radiography for treatment of periapical pathologies.By quantifying and digitally locating changes in bony density of periapical regions, and categorization into discrete groups, more thorough diagnosis affecting treatme...Mon, 26 Mar 2018 13:43:16 GMTchristopher.perkins@rutgers.edu Scarlet Fire® Dogwood – Cornus Kousa Rutpink, 23 Mar 2018 14:41:14 GMTchristopher.perkins@rutgers.edu New Method of Thin Film Patterning for Electronic and Medical Devices image of engineered patterns created on Bismuth thin filmInvention Summary: Rutgers Researchers have developed a new method of patterning metallic thin films. This technique provides an alternative to current thin film pattering techniques and introduces a new way of building out-of-plane structures from metallic thin films.Two of the most prevalent modes of patterning thin films are shadow masked deposition and photolithography. The former technique requires the creation of multiple yet expensive masks. The latter technique also uses masks and the process is complicated and introd...Wed, 14 Mar 2018 11:33:55 GMTchristopher.perkins@rutgers.edu Compositions and Methods, 14 Mar 2018 11:25:23 GMTchristopher.perkins@rutgers.edu Battery System Portfolio, 14 Mar 2018 07:47:51 GMTchristopher.perkins@rutgers.edu Platform Approach for Free Radical-Mediated Targeted Therapeutic Delivery Summary:Various pathological states including tissue injuries, inflammation, degenerative diseases and cancer are frequently associated with elevated free radicals, such as reactive oxygen and nitrogen species. These locally-generated free radicals are extremely reactive and are known to damage cells and tissues to exacerbate the pathology. Rutgers scientists have developed a novel strategy that aims to harness the reactivity of these free radicals to target and sustain the delivery of therapeutics. The therapeutic is conjugated to a biomaterial that reacts with free radicals to cros...Tue, 06 Mar 2018 13:56:35 GMTchristopher.perkins@rutgers.edu Exhaled Breath Condensate (EBC) Analyzer for Asthma Diagnosis and Monitoring Summary: Asthma, an increasingly important global health problem that affects ~ 300 million people worldwide, is characterized by variable airway inflammation and air flow obstruction. Currently available non-invasive methods for diagnosing and monitoring asthma involve measurements of exhaled nitric oxide (NO). Apart from the transient nature of NO, these methods are limited by low sensitivity and an inability to identify the nature and extent of airway inflammation. Measurement of alternative biomarkers in exhaled breath condensate (EBC) that can facilitate molecular phenotyping of...Mon, 22 Jan 2018 08:05:16 GMTchristopher.perkins@rutgers.edu Interferon Fusion Polypeptides as Antiviral and Cancer Therapeutics, 17 Jan 2018 08:24:47 GMTchristopher.perkins@rutgers.edu Phosphatidylserine-Targeting Immuno-Biologicals for Cancer and Viral Treatment Biological inhibits tumor growthInvention Summary: Phosphatidylserine (PS) is a phospholipid that is restricted to the inner plasma membrane in healthy cells. In the past decade, the constitutive externalization of PS has been observed in a wide range of solid tumors, and is considered a global immunosuppressive signal akin to other checkpoint inhibitory signals in the tumor environment. Rutgers scientists have developed a series of novel fusion proteins consisting of a PS-targeting domain and an immune-stimulating cytokine domain. The PS-targeting domain can target cancer cells w...Tue, 02 Jan 2018 12:16:19 GMTchristopher.perkins@rutgers.edu Eastern Oysters oysters (right, 3N) produced from improved tetraploids vs. normal diploid controls (left, 2N).Invention Summary:Rutgers University has been breeding eastern oysters (Crassostrea virginica Gmelin) since 1960. Rutgers oyster strains have shown strong to moderate resistance to two diseases (MSX and Dermo). Rutgers also invented tetraploid oysters (with 4 sets of chromosomes) and a new type of triploid oysters (with 3 sets of chromosomes) by crossing diploid and tetraploid oysters. Because of their sterility, superior growth, and improved summer meat quality, new triploid oysters develope...Tue, 02 Jan 2018 10:22:40 GMTchristopher.perkins@rutgers.edu Membrane for Separation and Filtration, 12 Dec 2017 12:48:48 GMTchristopher.perkins@rutgers.edu of p-Xylene by Dehydroaromatization of 3-Methyleneheptane obtained from Ethylene, 04 Dec 2017 12:54:33 GMTchristopher.perkins@rutgers.edu Balance, Mobility, and Fitness Rehabilitation Game (left) working with patient (right) within the VSTEP digital health platformInvention Summary:Restoring balance is critical for patients recovering from stroke, trauma, or joint surgery, as well as patients with other neurologic conditions. Virtual reality provides an opportunity to gamify rehabilitation and improve outcomes.Researchers at Rutgers have developed VSTEP, a digital health platform that addresses balance, mobility, and fitness. Infrared (IR), motion-sensing cameras track the movement of the lower extremities, providing feedback for balance movement training. Simultaneous...Wed, 22 Nov 2017 12:18:30 GMTchristopher.perkins@rutgers.edu Oxide Sedation for the Dental Team (Video and DVD), 11 Oct 2017 10:32:32 GMTchristopher.perkins@rutgers.edu, Bioactive Dental Implants, 15 Sep 2017 10:21:59 GMTchristopher.perkins@rutgers.edu radiative decay rate engineering for stable, phosphorescent emission of blue light radiative and non-radiative decay rate of phosphorescent emitting materials can be tuned by the geometry of the nanostructure (NP).Invention Summary: Blue-emitting, phosphorescent organic light emitting diodes (OLEDs) have high efficiency but low stability. As a result, the less efficient fluorescent materials are typically used in OLEDs to extend device lifetime. Much effort has focused on developing new, phosphorescent materials with increased intrinsic stability. Researchers at Rutgers have instead used an extrinsic approach to increasing stability of blue OLEDs. The presence of photoni...Mon, 28 Aug 2017 12:27:01 GMTchristopher.perkins@rutgers.edu<![CDATA[Novel Quantitative & Objective Analytical Tool for Detecting Neurodevelopmental Delays in Infants]]>, 14 Aug 2017 12:32:55 GMTchristopher.perkins@rutgers.edu Underwater Acoustic Lens Summary: Sending and receiving information below the water surface is important but challenging. Techniques such as Sonar use acoustic waves in water to transmit information. Acoustic metamaterials enable Sonar devices to control, direct and manipulate sound waves for increased functionality and higher efficiency. Specifically, acoustic lens has been developed as a transmissive device designed to refract and focus sound waves. Traditional underwater acoustic lenses only operate at high frequencies greater than 300 KHz, which limits their use in secure underwater communications. Rutge...Mon, 14 Aug 2017 12:10:32 GMTchristopher.perkins@rutgers.edu Quantitative Analytical Tool for Assessing Neurological Functions in Human Subjects, 11 Aug 2017 09:16:26 GMTchristopher.perkins@rutgers.edu Lateral Beam Expander for Mode Size Conversion, 03 Aug 2017 10:35:33 GMTchristopher.perkins@rutgers.edu Non-Membrane Feeding Device And Diet Formulation For Mosquito Colony Production, 25 Jul 2017 05:20:32 GMTchristopher.perkins@rutgers.edu Affirmation Treatment Videos for Young Transgender Patients, 24 Jul 2017 13:00:31 GMTchristopher.perkins@rutgers.edu Room Control Software, 24 Jul 2017 12:46:42 GMTchristopher.perkins@rutgers.edu Lunchbox: An Educational Kit for Teaching the Physics of Light Summary:The Luminescent Lunchbox is an educational tool kit that illuminates the physics of light through exciting experiments with glow-in-the-dark food. The tool kit includes materials and instructions for four exciting lab experiments. The experiments involve the use of light with food and make it fun for students in grades K-12 to learn and understand photophysical concepts such as the electromagnetic spectrum, absorption of light and fluorescence, use of spectrofluorometers to identify the composition of solutions and the use of absorptive filters.The Luminescent Lunchbox includ...Mon, 24 Jul 2017 11:50:44 GMTchristopher.perkins@rutgers.edu Screener for Young Children Summary:Effective screening during the toddler period may lead to timely detection of Autism Spectrum Disorder (ASD). The Autism Screener for Young Children is a Psychological Development Questionnaire. It is a brief parent-report questionnaire designed to represent the expression of social attention, communication and reciprocity in young children and inversely to detect children at-risk for ASD.Details:Researchers at Rutgers University have created a screening instrument comprised of a ten-item parent-report questionnaire. Parents, medical or educational personnel answer questions ...Mon, 24 Jul 2017 11:11:32 GMTchristopher.perkins@rutgers.edu™ I-O: An Economic Impact Model, 24 Jul 2017 10:40:28 GMTchristopher.perkins@rutgers.edu Curriculum to deal with Perinatal Mood Disorder Summary:Perinatal mood disorder includes major and minor depressive episodes that occur during pregnancy or shortly after delivery and is a common medical complication affecting one in seven women. The INSPIRE project at Rutgers University has been created to help women who are suffering with this disorder. A curriculum that uses artistic expression and creative story-telling has been designed for the project that will be used in support groups of new and expecting mothers struggling with the transition to motherhood. The curriculum is designed for use in a larger project which seeks...Mon, 24 Jul 2017 07:49:24 GMTchristopher.perkins@rutgers.edu Dual Cell Therapy for Wound Healing, 21 Jul 2017 09:13:55 GMTchristopher.perkins@rutgers.edu Polyelectrolyte Membranes for Protection against Chemical Warfare Agents of muticatalyst polyelectric membrane (PEM) for protection against chemical warfare agents (CWAs). Polyoxametalate nanoclusters and metal oxide nanoparticles contribute catalytic activityInvention Summary:To protect a wearer from toxic chemicals, such as chemical warfare agents (CWAs), materials must be both permeable to water vapor and impermeable to those CWAs. While developing such materials is a significant engineering challenge, those materials would provide only a physical barrier between the wearer and CWAs. Researchers at Rutgers have developed a selectively permeable polyele...Tue, 16 May 2017 06:11:17 GMTchristopher.perkins@rutgers.edu Novel Vaccine Candidate Against Fungal Infection infected with mutant fungal strain display enhanced inflammatory response and survival A.) Flow cytometric analysis of cellular infiltration in the lungs shows higher number of CD4+ T cells and monocytes for mice infected with live mutant strain. B.) Vaccinated mice (C57BL/6J and A/J) with heat killed mutant strain showed higher survival rate when challenged with wild strain (H99) of fungus.Invention Summary:Invasive fungal infections kill over 1.5 million people worldwide annually. Cryptococcus neoformans, for example is a human fungal pathogen that often causes lung and brain infection ...Fri, 12 May 2017 13:08:13 GMTchristopher.perkins@rutgers.edu Resolution, Real-Time Flatness and Thermal Expansion Metrology of surface curvature measurement and thermal expansion measurement apparatusInvention Summary:During manufacturing of thin films and semiconductors, it is critical to monitor the flatness and thermal expansion of samples to identify and manage stresses. These parameters are currently measured optically based on the deflection of multiple parallel beams, but, this approach is limited in the sample size, resolution, and the distance between the sample and the measurement apparatus.Researchers at Rutgers have developed a novel metrological apparatus to overcome these limitations. Specif...Fri, 12 May 2017 12:51:16 GMTchristopher.perkins@rutgers.edu Computer-Aided Detection of Abnormal Regions in Medical Images operator characteristic curves for detection of prostate cancer at various weights (T) in histological (top) and MRI (bottom) images. Classification is based on multiplicative weighted maximum a posteriori (MWMAP) estimation with iterated conditional modes (ICM). The regions labeled as malignant at three weights are highlighted in green (histology) or red (MRI)Invention Summary:Detection of abnormal features in medical images is a time-consuming task performed by pathologists. Although computer analysis can increase throughput, the size of the images often limits processing speeds. Th...Mon, 17 Apr 2017 06:15:22 GMTchristopher.perkins@rutgers.edu Water Purification Technology for Lead and Heavy Metals, 05 Apr 2017 11:56:12 GMTchristopher.perkins@rutgers.edu Efficient Cancer Drug Delivery Method of siRNA and Erlotinib for synergistic cancer therapyInvention Summary:Combination therapies have been extensively explored in the oncology field, for its potential to improve treatment efficacy, minimize the risks of resistance, and reduce adverse effects. Rutgers researchers have developed a novel drug delivery system for the combined delivery of anti-cancer drug Erlotinib (Tarceva) and nucleic acid molecules (eg. siRNA), which may lead to synergistic treatment effect. This invention utilizes novel cyclodextrin-modified dendritic polyamines (DexAMs) as a vehicle to co-deliver Erl...Wed, 29 Mar 2017 12:24:00 GMTchristopher.perkins@rutgers.edu Pre-Vascularized Scaffold of load-bearing scaffold: osteonal cortical section, porous trabecular section, vascularized osteon, hydroxyapatite columnsInvention Summary:This load-bearing scaffold mimics the native structure of cortical and trabecular bone to improve outcomes of orthopaedic surgeries. The biodegradable, polymeric scaffold has a porous trabecular section surrounded by a cortical section with vertically oriented channels that mimic osteons. Hydroxyapatite columns provide additional structural support to the cortical section, and the scaffold is further mineralized. The osteon-like channels are see...Mon, 27 Mar 2017 13:01:04 GMTchristopher.perkins@rutgers.edu<![CDATA[Stem Cell Growth Matrices with Enhanced Homogeneity, Stemness & Proliferation and Reduced Need for Feeding]]> Summary:There is currently no universal platform or widely accepted technique to efficiently and reproducibly grow stem and progenitor cells (SPCs) in vitro. Stem cells require contact with extracellular matrices as well as signals from growth factors to proliferate and to retain their stemness (preventing their differentiation towards progenitors). Rutgers researchers Dr. Steven Levison and Dr. Nolan Skop have developed a multi-functional scaffold that supports the expansion of neural stem cells and neural progenitors. This scaffold can be adhered to tissue culture plates (Stemtrix ...Fri, 24 Mar 2017 13:38:00 GMTchristopher.perkins@rutgers.edu Use of Brassinosteroids for Muscle Growth, Skin, 20 Mar 2017 12:34:11 GMTchristopher.perkins@rutgers.edu Voltage TFT On Glass For Solar Inverters, 24 Jan 2017 05:46:18 GMTchristopher.perkins@rutgers.edu for Drug-Resistant Bacterial Infections - Myxopyronins, 04 Jan 2017 08:43:54 GMTchristopher.perkins@rutgers.edu for Drug-Resistant Bacterial Infections: Inhibitors of Bacterial RNA Polymerase, 04 Jan 2017 08:24:58 GMTchristopher.perkins@rutgers.edu for Tuberculosis: Novel Inhibitors of Mycobacterial RNA Polymerase, 04 Jan 2017 07:49:48 GMTchristopher.perkins@rutgers.edu Quantitative Assays, 10 Nov 2016 10:53:39 GMTchristopher.perkins@rutgers.edu FISH probes for the prognosis of malignant transformation in Barrett’s epithelium, 27 Oct 2016 13:13:09 GMTchristopher.perkins@rutgers.edu<![CDATA[Highly Selective & Rapid Separation of iPSCs from Differentiated Cells]]> Summary:Human induced pluripotent stem cells (iPSCs) hold great promises for disease modeling and drug discovery. However, a rate-limiting step in iPSCs derivation is their separation from differentiated cells. It takes about 10 separations and passages for an iPSC clone to become stable, with minimal differentiation. Traditionally, at every passage, the researchers need to either manually pick the iPSCs from differentiated cells or mechanically scrape the differentiated cells from the plate. As such, for one 6-well plate, an experienced lab researcher typically spends 6-7 hours scra...Wed, 26 Oct 2016 12:14:49 GMTchristopher.perkins@rutgers.edu RNAi-mediated method for resistance to soybean cyst nematode siRNA-transgenic soybean plants are 40-80% (approx.) more resistant to soybean cyst nematode as compared to the wild type plants (wt). The percentage of reduction in egg number is shown above the bar for each transgenic soybean line.Invention Summary:Rutgers scientists have developed a new method for inducing resistance to soybean cyst nematode (SCN) by using root-specific RNA interference (RNAi) technology.Specifically, RNAi was used to express small RNAs targeting a critical SCN ribosomal gene under the root-specific promoter in soybean plants. Homozygous transgenic soybean plants...Wed, 07 Sep 2016 12:56:25 GMTchristopher.perkins@rutgers.edu Efficiency Isotope Enriched Protein Production Systems Enrichment of Tryptic FragmentsInvention Summary:Rutgers scientists have developed two Single Protein Production (SPP)-based systems to obtain high levels of specific isotopically enriched proteins: an independently inducible system (cSPP(tet)) and an amino acid auxotroph-based dual inducible system. The proprietary SPP system, developed at Rutgers and currently licensed to Takara Bio Inc., essentially turns living E. coli cells into a bioreactor for producing a single protein of interest at high levels. The system utilizes an E. coli endoribonuclease, MazF, to selectively cleave cell...Fri, 12 Aug 2016 12:26:33 GMTchristopher.perkins@rutgers.edu Methionine, Enhanced Protein Corn with a Sturdy Kernel Summary:A multi-faceted invention combining high amino acid enhanced corn with increased kernel hardness, offering nutritional and commercial benefits to breeders, producers, and consumers.Market Application:Animal feedSweet cornPet foodCorn productsAdvantages:Use of corn with increased levels of essential amino acids reduces the need of more costly soybeans and chemically synthesized methi- onine to achieve desired nutrition profiles; it also eliminates the cost of synthetic methionine for feed supplementation. Chemically synthesized methi- onine is also produced as racemic DL-methi...Wed, 15 Jun 2016 13:41:31 GMTchristopher.perkins@rutgers.edu of Field Performance in Woody Perennials Resulting from Engineered Nitrogen Use Efficiency (NUE) Summary:Rutgers scientists have introduced a pine gene for ammonium assimilation (glutamine synthetase [GS]) into poplar resulting in superior field performance including increased height and volume growth compared with non-transgenic controls. The GS transgenics can contribute significantly to strategies for increasing energy biomass production in woody perennials. Our approach to engineering NUE can contribute significantly to strategies for increasing energy biomass production in woody perennials.Market Applications:We believe this technology is applicable not only to increasingly...Wed, 15 Jun 2016 13:32:08 GMTchristopher.perkins@rutgers.edu Venus® Dogwood, 15 Jun 2016 13:19:00 GMTchristopher.perkins@rutgers.edu Bioaerosol Sampler using Ferroelectric Polymer, 20 May 2016 09:16:52 GMTchristopher.perkins@rutgers.edu Diagnostic Tool to Quantify Signatures of Movement in Subjects with Neurological Disorders, Autism and Autism Spectrum Disorders, 16 Mar 2016 10:52:19 GMTchristopher.perkins@rutgers.edu Bug Seizer Attractant and Monitoring System, 11 Mar 2016 10:52:09 GMTchristopher.perkins@rutgers.edu of Asymmetric Reactions using Metallorganocatalysts of the active complex during the asymmetric hydrogenation of nitroalkenes using the developed chiral biphosphine metallorganocatalystsInvention Summary:To improve the inherent limitation of transition metal catalysts and organocatalysts, researchers have combined the two for synergistic effects. Despite the efforts, compatibility between catalysis, intermediates and solvents have been a limiting factor. Research at Rutgers University have developed effective and versatile biphosphine metallorganocatalysts. The catalysts are highly efficient and compatible with several reaction condit...Thu, 10 Mar 2016 12:06:35 GMTchristopher.perkins@rutgers.edu Synthetic Transcription Factor for Enhanced Gene Expression AuSTF nuclear localization and reporter gene inductionInvention Summary:Rutgers scientists have developed novel gold nanoparticles (AuNPs) functionalized with synthetic transcription factor (STF) components (AuSTF) capable of permeating the plasma membrane, targeting and entering the nucleus, and initiating transcriptional activity of endogenous genes. STFs are comprised of synthetic small molecules and peptides, and can be potentially applied to investigate genome-wide transcriptional cascades, treat or repair malfunctioning signaling cascades within the cell, and guide differentiation or de...Thu, 18 Feb 2016 08:19:01 GMTchristopher.perkins@rutgers.edu Class of Biofertilizer Promoting Growth and Stress Tolerance Summary:Rutgers scientists have identified ACC-deaminase-producing bacterial strains that have advantageous effects on overall plant growth, in particular, turfgrass. Plants infected with ACC-deaminase-producing bacteria are exposed to less ethylene, and thus exhibit better overall growth. Indeed, plants inoculated with these bacteria species and strains were found to have better growth and quality levels and exhibit enhanced resistance to environmental stressors.Market Applications:AgricultureTurfgrassHorticulture BioFertilizer Advantages: Natural biofertilizerNo known side effect/t...Wed, 18 Nov 2015 08:39:39 GMTchristopher.perkins@rutgers.edu Personal Electrostatic Bioaerosol Sampler (PEBS), 14 Oct 2015 08:17:17 GMTchristopher.perkins@rutgers.edu and Biocompatible Bioactive-based Polymers for Dental Applications Summary:The Uhrich group at Rutgers University has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), and antibiotics (e.g., amoxicillin). Bioactive molecules are incorporated into polymer backbones through labile linkages, enabling high bioactive loading and sustained and controlled release upon degradation (e.g., hydrolysis). The release profile is well controlled based on the polymer chemical compositions and can be adjusted to desired release time frame (from hours, days, t...Tue, 18 Aug 2015 13:06:59 GMTchristopher.perkins@rutgers.edu Novel Method for Diagnosing and Monitoring Brain Trauma Patients, 28 Jul 2015 08:43:32 GMTchristopher.perkins@rutgers.edu Humanized Yeast System for mTOR Kinase Inhibitor Screening and Studies, 28 Jul 2015 07:16:42 GMTchristopher.perkins@rutgers.edu Novel Diagnostic Assay for Predicting Patients’ Resistance to mTOR Kinase Inhibitors Summary:Mechanistic Target of Rapamycin (mTOR) is a highly conserved serine/thereonine protein kinase that plays a crucial role as part of two distinct kinase complexes, mTOR1C and mTOR2C, to regulate cell growth and metabolism. Abnormal activation of mTOR has been implicated in the pathogenesis of several cancers, type 2 diabetes, obesity, and neurodegeneration. Numerous mTOR kinase inhibitors are currently in development with several currently be evaluated as anticancer therapy in clinical trials. However, given recent clinical experience with target therapeutics, acquired drug res...Tue, 28 Jul 2015 06:17:22 GMTchristopher.perkins@rutgers.edu™ Botanical-derived Functional Ingredients for Food, Beverages, Nutrition, 10 Jul 2015 09:22:40 GMTchristopher.perkins@rutgers.edu<![CDATA[Nutrasorb™ Botanical Functional Ingredients for Cosmetic, Personal & Skin Care]]>, 10 Jul 2015 09:16:00 GMTchristopher.perkins@rutgers.edu and Biocompatible Bioactive-based Polymers - Versatile Platform Technology, 07 Jul 2015 12:12:45 GMTchristopher.perkins@rutgers.edu Flow Deflector Summary:With the potential to increase wind farm revenue by up to 30%, this invention consists of several aerodynamic elements which can be retrofitted to any existing wind turbine blade. It can be applied to any current or any new wind turbine design. It is passive and does not require any external power to function, the aerodynamic elements are typically shaped as flat plates or thin airfoils, and it can be combined with vortex generators.The deflector has been found to increase power generation by 10% when added to wind turbine blades in recent prototype tests. This translates int...Fri, 15 May 2015 06:41:14 GMTchristopher.perkins@rutgers.edu Promoting Properties of Newly Identified Root Fungi A. panicicola for Agricultural Applications Summary:Rutgers scientists identified a new root endophytic fungal species, Acidomelania panicicola, which significantly increases growth and stress tolerance of different plant species. A. panicicola was identified from switchgrass and other grass roots from the New Jersey Pine Barrens, where the soil content is nutrient poor, acidic, dry and has high levels of toxic soluble aluminum. Functional studies showed that A. panicicola significantly increased the root hair growth in switchgrass, rice and lettuce seedlings under acidic and poor nutrient conditions. In addition, inoculation ...Fri, 24 Apr 2015 12:56:07 GMTchristopher.perkins@rutgers.edu Nutraceutical Compositions containing Phenethylisothiocyanate and their Uses as Anti-Inflammatory Agents paw edema anti-inflammatory assays demonstrated that treatment with PEITC essential oil (PEO) was as quick and effective as treatment with aspirin.Invention Summary:Rutgers scientists have developed proprietary and unique methods for obtaining high yields of phenethyl isothiocyanate (PEITC), a natural glucosinolate derivative known for its cancer preventive and antiinflammatory properties, from plant tissues (e.g., seeds). After evaluating various plant species and tissues for their PEITC content, it was found that the seeds of Barbarea verna (also known as early winter cress or upland cre...Mon, 23 Feb 2015 11:18:14 GMTchristopher.perkins@rutgers.edu Adaptor: Demonstrated In Vivo Potency and Low Toxicity Provide Clear Advantages for a Next-Generation Gene Silencing Technology in Life Science Research Summary:Rutgers scientists have developed compositions of single-stranded oligonucleotides that inhibit RNA biosynthesis by a novel mechanism of action. This enables the development of highly efficient gene silencing agents that have shown unprecedented inhibitory levels both in vitro and in vivo. The U1 adaptor consists of two parts, a target-gene binding domain and a U1 domain that attracts and inhibits the cellular polyA-tail addition apparatus. By combining both capabilities in the same molecule, the U1 adaptor can specifically inhibit the pre-mRNA maturation step of polyA-tail a...Fri, 13 Feb 2015 13:17:46 GMTchristopher.perkins@rutgers.edu Diagnostics of Tick-borne Diseases, 28 Jul 2014 06:45:59 GMTchristopher.perkins@rutgers.edu FOR DIAGNOSING, PREVENTING, AND TREATING DEVELOPMENTAL DISORDERS DUE TO A COMBINATION OF GENETIC AND ENVIRONMENTAL FACTORS Summary:Schizophrenia is a developmental disorder caused by brain damage in a fetus due to maternal genetic and environmental factors. The genetic factors have not been definitively identified due to several factors: 1) involvement of more than one gene 2) uncertainty in the mode of inheritance 3) a high frequency of the allele being tested in the population being screened. The environment around the developing fetus is contributed by maternal components and there is a growing appreciation that a combination of fetal environmental and maternal genetic factors during the second trimes...Thu, 10 Jul 2014 09:13:46 GMTchristopher.perkins@rutgers.edu Unmanned Vehicle Operational in Air and Underwater, 10 Jul 2014 06:56:58 GMTchristopher.perkins@rutgers.edu MORPHOGENETIC PROTEIN-2 AND BONE MORPHOGENETIC PROTEIN-4 IN THE TREATMENT AND DIAGNOSIS OF CANCER Summary:BMP-2 expression is linked to cancer invasion and. BMPs are synthesized as inactive proteins of variable length. The precursor BMP-2 and BMP-4 proteins are proteolytically cleaved, producing mature C-terminal proteins of a little more than 100 residues. BMP-2 and BMP-4 interact with the same binding sites: mature BMP-2 and BMP-4 protein signaling is mediated by transmembrane serine/threonine kinases called type IA, IB, and type II receptors. The receptor phosphorylates cytoplasmic targets, which include the Smad family of proteins. In addition, the same molecules including no...Mon, 07 Jul 2014 11:44:10 GMTchristopher.perkins@rutgers.edu GROWTH FACTOR INDUCIBLE NEUROKININ-1 GENE, 07 Jul 2014 11:44:09 GMTchristopher.perkins@rutgers.edu methods for protein profiling, 02 Jul 2014 11:41:27 GMTchristopher.perkins@rutgers.edu Isoform and Diagnostic and Therapeutic Uses Therefor, 02 Jul 2014 11:41:26 GMTchristopher.perkins@rutgers.edu Safety Syringe Summary:As per OSHA estimates, 5.6 million workers in the health care industry are at risk of exposure to bloodborne pathogens, including human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) due to needlestick injuries. About 600,000 to 800,000 needlestick injuries occur annually among healthcare workers and this remains an important concern and represents significant financial burden to healthcare. A large number of these injuries can be prevented by engineering syringe safety mechanisms. The current invention provides a disposable safety syringe syst...Wed, 02 Jul 2014 11:41:25 GMTchristopher.perkins@rutgers.edu A-4 ANALOGUES FOR CANCER THERAPY Summary:Cancer is one of the most common human diseases, and leads to about 12% of all deaths worldwide. Mitotic inhibitors such as paclitaxel, which is a tubulin-binding compound that disrupts the formation of mitotic spindles, are widely used for the treatment of cancer, and have achieved great commercial successes. However, these clinically used anti-tubulin drugs often face severe limitations such as neural and systemic toxicity, multiple side effects, induction of drug resistance, and complex synthetic pathways and isolation methods. Combretastatin A-4 (CA-4) is a potent tubulin...Wed, 14 May 2014 06:17:19 GMTchristopher.perkins@rutgers.edu Short Peptide and Its Mimics as Immuno/Inflammatory Modulators, 09 May 2014 11:36:20 GMTchristopher.perkins@rutgers.edu of Thermal Stability of Collagen Triple Helix Summary:Collagens are the major structural proteins in the extracellular matrix of animals, including all vertebrates and invertebrates, and are defined by a characteristic triple-helix structure that requires a (Gly-Xaa-Yaa)n repeating sequence . Collagen is the most widely used biomaterial in a wide variety of biomedical applications including cosmetic surgery, tissue engineering, and drug delivery. For these applications, collagen is usually extracted from animal sources, especially bovines, but there has been a growing concern of transmissible diseases from these sources. Other c...Fri, 09 May 2014 08:53:36 GMTchristopher.perkins@rutgers.edu AND SYSTEM FOR TRANSCUTANEOUS MONITORING OF ENDOTRACHEAL TUBE PLACEMENT Summary:Intubating a patient always poses a challenge due to the anatomy of the throat. Most often the tube is inserted into the esophagus by mistake. Insertion of an endotracheal tube into the trachea requires a skilled practitioner and direct visualization that requires the use of a laryngoscope. After the insertion of the laryngoscope into the mouth, the neck of the patient needs to be extended so the inlet of the trachea can be visualized to navigate the tube directly toward it. The procedure is cumbersome and poses a serious risk for patients with neck injury. Researchers at Rut...Wed, 12 Mar 2014 11:55:30 GMTchristopher.perkins@rutgers.edu for modulating inflammatory responses Summary:Cholesterol is a major component of lipid rafts, which are sphingolipid-enriched planar domains of the cell membrane. Rafts play key roles in a variety of the cell signals processes including calcium entry into cells, which activates white blood cells and causes inflammation. Many inflammatory cell responses are tightly controlled by the regulated entry of Ca 2+ ions into the cells. Because innate immune cells lack voltage-gated calcium channels, their response to G-protein coupled (GPC) mediators depends in a great measure on store-operated calcium entry (SOCE) into the cell...Wed, 12 Mar 2014 11:55:30 GMTchristopher.perkins@rutgers.edu OF TREATING AUTISM Summary:DHA is the major brain lipid. Recent studies by several groups of investigators have shown that DHA is the parent molecule for a large number of intracellular and extracellular messengers. Chronic perturbation of the pathways regulated by these molecules could account for the subtle behavioral effects seen with neurological diseases. Oxidation of DHA gives rise to a series of non-enzymatically produced analogs of the enzymatically derived products (neuroprostanes). Since the structure and chemistries of these neuroprostanes are so similar to the enzymatically-produced compoun...Mon, 10 Mar 2014 07:33:55 GMTchristopher.perkins@rutgers.edu to Modulate the Immune System Using Mesenchymal Stem Cells, Cytokines and Chemokines, 05 Mar 2014 09:03:24 GMTchristopher.perkins@rutgers.edu Cancer Therapy Based On A Telomerase Reverse Transcriptase Variant Summary:Telomeres, the protein-DNA structures located on the ends of eukaryotic chromosomes, are required for chromosome stability during DNA replication. Studies have demonstrated that telomere length may serve to limit the replication potential of cells, hence serve as a barrier to immortalization and carcinogenesis. Telomerase plays a key role in maintaining telomere function and activity by catalyzing telomere replication. In human, telomerase activation is observed in 90% of all tumors. Therefore, telomerase is a bona fide target for development of agents directed to cancer ther...Wed, 05 Mar 2014 08:27:51 GMTchristopher.perkins@rutgers.edu METHOD TO MEASURE IGF TYPE I RECEPTOR AND INSULIN RECEPTOR ISOFORM EXPRESSION Summary:It has been generally accepted that although insulin (IR) and the insulin-like growth factor (IGF-IR) receptor pathways have similar structure and function, they exert different physiological actions in disease and non-disease states. Studies have shown that, in normal states, IR is responsible for mediating downstream targets involved in metabolic functions. In contrast, the IGF-IR mediates the activation of target genes involved in cell growth and differentiation. It has recently become clear that there exists multiple isoforms of signaling receptors, which include hybrid r...Wed, 05 Mar 2014 08:27:50 GMTchristopher.perkins@rutgers.edu GLUTATHIONE S-TRANSFEREASE P1 HAPLOTYPE ACTING IN MOTHERS DURING PREGNANCY MAY INCREASE RISK OF AUTISTIC DISORDER IN HER AFFECTED OFFSPRING, 05 Mar 2014 08:27:49 GMTchristopher.perkins@rutgers.edu OF GSTM1 WITH AUTISM AND ASSAYS AND METHODS BASED THEREON Summary:Autism is a pervasive developmental disorder with diagnostic criteria based on abnormal social interactions, language abnormalities, and stereotyped patterns of behavior evident prior to 36 months of age. Despite its lack of Mendelian transmission, autism is highly genetically determined. Although the vast majority of cases are unrelated to known teratogens, phenotypic expression of autism may be affected by the interaction of environmental factors with multiple gene loci. Oxidative stress could interact with common functional polymorphic variants of genes that protect agains...Wed, 05 Mar 2014 06:56:09 GMTchristopher.perkins@rutgers.edu of Human Endogenous Retrovirus Expression in Cancer and Normal Cells, 25 Feb 2014 08:19:25 GMTchristopher.perkins@rutgers.edu and Easily Recyclable Heterogeneous Nanocatalysts, 07 Feb 2014 11:20:28 GMTchristopher.perkins@rutgers.edu and Partially-Oxidized Metallic Plasmonic Electrodes for Inverted Bulk Heterojunction Photovoltaics Summary:The demand to find novel sources of clean, renewable energy has grown significantly over the past several decades. One promising source of renewable energy is in the form of photovoltaic (PV) cells - devices that convert sunlight into electricity. Traditionally, inorganic semiconducting materials are used to create the p-n junction necessary to achieve the photovoltaic effect; these types of materials, however, are rather difficult to process due to the sensitivity of inorganic semiconductors to impurities. Traditional photovoltaics are limited in the structural flexibility l...Thu, 06 Feb 2014 12:24:41 GMTchristopher.perkins@rutgers.edu<![CDATA[SAFE AND EFFECTIVE TOPICAL MEDICATION (SOLUTION, CREAM & PATCH) TO TREAT CUTANEOUS HEMANGIOMA]]> Summary:Capillary hemangioma is the most common benign tumor of the eyelid/orbit in children and affects up to 2% of infants, over 1.7 million children in USA and over 10 million children worldwide. If not treated promptly, it can cause blindness. Overall, the incidence of cutaneous hemangioma is widely prevalent resulting in physically disfiguring and psychologically disturbing lesions in all age groups affected. Systemic or intra-lesional corticosteroids are commonly used as first line treatment. Alternative treatments include laser photocoagulation, surgical excision and immunomod...Thu, 06 Feb 2014 11:58:52 GMTchristopher.perkins@rutgers.edu VANILLOID CARBAMATES, 06 Feb 2014 11:51:37 GMTchristopher.perkins@rutgers.edu Reconstruction Summary:Magnetic Resonance (MR) imaging has been widely used in medical diagnostics because of its non-invasive manner and excellent depiction of soft tissue changes. Image reconstruction methodologies are vital to many applications in medical imaging. Recent developments in compressive sensing theory show that it is possible to accurately reconstruct the Magnetic Resonance (MR) images from highly undersampled K-space data and therefore significantly reduce the scanning duration. Researchers at Rutgers University have developed a sparsity technique for efficient MR image segmentation...Tue, 04 Feb 2014 06:55:29 GMTchristopher.perkins@rutgers.edu Screen Battery for Emission Control of the ESBEC systemInvention Summary:Electrostatic Screen Battery for Emission Control (ESBEC) is a device for capturing airborne particulate matter emissions from a variety of mobile and stationary sources, such as diesel engines used in automobiles, marine engines, agricultural equipment, power generation equipment, etc. The ESBEC collects and allows for subsequent removal of collected airborne particulate matter using a wire mesh screen coated with superhydrophobic material and supplied with high voltage. The superhydrophobic coating on the screen surface enables easy removal of ...Tue, 04 Feb 2014 06:55:15 GMTchristopher.perkins@rutgers.edu Airborne Contaminant Collector: Very High Concentration Rate and Low Power Consumption, 04 Feb 2014 06:55:08 GMTchristopher.perkins@rutgers.edu to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics, or Other Agents pictures showing wide variation in cellular uptake of radiopharmaceuticals.Invention Summary:A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic agents by diseased cells varies dramatically even under ideal conditions. Accordingly, treatment with a single pharmaceutical is not likely to target all cells adequately to achieve the desired therapeutic outcome. To increase treatment effectiv...Wed, 22 Jan 2014 11:38:30 GMTchristopher.perkins@rutgers.edu RNA Restriction Enzymes, 22 Jan 2014 11:21:48 GMTchristopher.perkins@rutgers.edu Sensor Radio Scene Analysis for Packet Based Radio Signals Using 2nd and 4th Order Statistics Summary:Most existing wireless systems use static allocation of the radio spectrum with each system operating in a predefined fixed frequency band. Since the allocated spectrum is not used at all locations and at all times, this static allocation leads to creation of spectrum holes, which implies inefficient utilization of the available radio spectrum. Dynamic spectrum allocation offers a much more optimal spectrum utilization scheme. However, dynamic systems must have a completely new feature embedded in them, spectrum sensing capability. Spectrum sensing can be defined as RF signal...Thu, 09 Jan 2014 10:15:46 GMTchristopher.perkins@rutgers.edu Biomaterials Portfolio Hydroxyapatite, HAp, chemical formula Ca10 (PO4)6(OH)2 has attracted the attention of researchers over the past thirty years as an implant material because of its excellent biocompatibility and bioactivity. HAp has been used extensively in medicine for implant fabrication. It is commonly the material of choice for fabricating dense and porous bioceramics. Its general uses include biocompatible phase-reinforcement in composites, coatings on metal implants and granular all for direct incorporation into human tissue. Other potential nonmedical applications include a packing material/support for ...Mon, 06 Jan 2014 13:23:44 GMTchristopher.perkins@rutgers.edu Actuator Array Technology for Propulsion, and Flow Control for Underwater Vehicles Summary:Nano Electrokinetic actuators are a novel propulsion method for underwater vehicles. Of significant relevance is the ability to create faster more maneuverable underwater vehicles. These novel actuators operate on a fundamentally different principle from the traditional actuator technologies used to date. The technology takes advantage of electro-osmosis to enable fluid pumping using electric fields. The application is extensively used in micro fluidic devices. Researchers at Rutgers University have developed a new class of fluid micro/nano actuators with superior performance...Mon, 23 Dec 2013 05:45:33 GMTchristopher.perkins@rutgers.edu to Prepare and Apply Flame-retardant Coating Composed of Polyurethane, Isopropyl Alcohol and Magnesium Hydroxide Suspension Summary:In the past, fire proofing plastic involved embedding flame retardant particles directly into the resin matrix. The technique is fine for materials which are not meant to bear loads. However, the amount of flame-retardant particles needed to be effective in higher mass objects is problematic do to the disruption of the networks within a plastic. Therefore, embedded particles are suitable for thinner products, for example casings for electronics and dash boards for cars. However, for structural applications of plastic a different approach must be considered to reduce the threa...Tue, 29 Oct 2013 10:22:04 GMTchristopher.perkins@rutgers.edu Quartz Crystal Microbalance-based Biosensor for Dynamic and Non-invasive Cellular Monitoring Summary:Non-invasive, real-time examination of live cell function is essential in understanding the mechanistic and dynamic progression of biological processes. Existing cell monitoring methods often require removal of cells from the culture environment followed by fixation and labeling, which can be a slow and tedious process. Researchers at Rutgers University have developed a new technology to non-invasively monitor biological cell dynamics associated with cell growth and cell death. More specifically, they have developed Zinc Oxide (ZnO)-nanostructured biosensors that include Quar...Wed, 18 Sep 2013 10:09:07 GMTchristopher.perkins@rutgers.edu Stellar Pink® Dogwood, 19 Jul 2013 05:41:20 GMTchristopher.perkins@rutgers.edu RECOGNITION BIOFEEDBACK Summary:Grasping an object is one of the most fundamental activities of daily living. Unfortunately hand dexterity is usually impaired following stroke or traumatic brain injury. As anyone who has suffered a broken bone will attest, the lack of usage of the appendage leads to muscular atrophy. The lack of usage also tends to impede recovery; therefore, grasp training and usage of the muscle groups is a high priority for rehabilitation of the upper limbs. Researchers at Rutgers University have developed a rehabilitation device for improving fine motor function in persons with brain in...Sat, 13 Jul 2013 11:21:16 GMTchristopher.perkins@rutgers.edu of an Insect-Growth Regulator for Mosquito Management Summary:Rutgers scientists have developed an insecticide (e.g, pyriproxyfen) autodissemination station that topically contaminates oviposition-seeking mosquitoes in such a manner that the mosquitoes then bring the active control agent back to their breeding locations for control of container-inhabiting mosquitoes in urban environments, particularly the Asian tiger mosquito. The targeted mosquito is prevalent around the world, infesting all inhabited continents and thirty states, and is a carrier of more than twenty pathogens of public and veterinary health importance, including dengu...Mon, 01 Jul 2013 06:06:07 GMTchristopher.perkins@rutgers.edu University Mullica Queen® Cranberries, 01 Jul 2013 06:05:56 GMTchristopher.perkins@rutgers.edu for Enhancing Anaerobic Degradation of Methyl Tert-butyl Ether (MTBE) and Structurally Related Fuel Oxygenates* The slower degradation of MTBE at higher concentrations of syringate may be due to an inhibitory effect of syringate at higher concentrations.Invention Summary:Methyl tert-butyl ether, a volatile synthetic compound, has been the most frequently used fuel oxygenate which, when used with gasoline, increases octane and reduces combustion emissions. As it is a frequent water contaminant that is difficult to remove by most physical methods, a treatment of fuel-contaminated water is required. Rutgers scientists have discovered a novel method for the anaerobic degradation of MTBE and other relevant...Mon, 01 Jul 2013 06:05:55 GMTchristopher.perkins@rutgers.edu Red Beauty® Holly, 01 Jul 2013 06:05:50 GMTchristopher.perkins@rutgers.edu to Produce Hepatitis C Virus E2 Protein Summary:Rutgers scientists have developed methods to produce and purify the ectodomain of HCV E2, a critical structural protein of the virus that has potential to serve as a vaccine candidate to prevent HCV infection. Efforts to study HCV, and to develop vaccines, have been impaired in part by the inability to produce sufficient quantities of high quality protein due to the complexity of the mature form of E2. The technology developed at Rutgers has overcome this limitation and may provide the critical step towards developing a variety of therapeutic options including vaccines agains...Tue, 18 Jun 2013 12:02:21 GMTchristopher.perkins@rutgers.edu Myxopyronin Analogs for Broad Spectrum Antibacterial Applications, 18 Jun 2013 12:02:14 GMTchristopher.perkins@rutgers.edu Surface Design of Tyrosine-Derived Polycarbonates for Attachment of Biomolecules in Medical Polymers Summary:Rutgers scientists have developed a way to attach biomolecules to 3D tyrosine-derived medical polymers and polymer scaffolds in order to aid in cellular responses in wound healing. When incorporating into scaffolds, these polymers have a novel molecular surface design that tethers biomolecules using biotin (Vitamin H) binding. The addition of biotin to the polymer scaffold does not cause significant change to the properties of the polymer yet allows biomolecules to be efficiently tethered throughout the polymer structure within minutes. Furthermore, the resulting polymer scaf...Thu, 13 Jun 2013 11:34:55 GMTchristopher.perkins@rutgers.edu Facial Features Using Cluster of Point Distribution Models, 13 Jun 2013 06:11:20 GMTchristopher.perkins@rutgers.edu Diagnostic DNA Arrays for Pathogen Detection and Identification 7 times higher signal intensity was obtained for the dimeric probes D and the dimeric probes with a 10-adenine spacer DA compared to conventional monomeric probes M.Invention Summary:Rutgers scientists have developed a unique and pioneering technology for detection and identification of important pathogens in the form of a macroarray diagnostic technology with enhanced detection sensitivity and small reduction in specificity using repeat sequence probes (dimers). We continue to have positive results and improvements, and believe the next stage will focus on refinement, development of a porta...Tue, 11 Jun 2013 11:09:47 GMTchristopher.perkins@rutgers.edu Variegated Stellar Pink Dogwood, 11 Jun 2013 09:42:45 GMTchristopher.perkins@rutgers.edu TOUCH COMMUNICATION: A TECHNIQUE TO INPUT DATA TO CAPACITIVE TOUCHSCREEN DEVICES Summary:Mobile devices now provide us ubiquitous access to a vast array of media content and digital services. They allow us to access our emails and personal photos, open our cars or our garage doors, pay bills and transfer funds between our bank accounts, order merchandise, as well as control our homes. They arguably now provide the de-facto single sign on access to all our content and services, which has proven so elusive on the web. As we increasingly rely on a variety of such devices, we tend to quickly switch between them and temporarily share them with others causing potential...Tue, 04 Jun 2013 12:41:24 GMTchristopher.perkins@rutgers.edu Diagnostic Tool to Quantify Signatures of Novel Diagnostic Tool to Quantify Signatures of Movement in Subjects with Neurological Disorders, Autism and Autism Spectrum Disorders, 04 Jun 2013 12:40:37 GMTchristopher.perkins@rutgers.edu™: Novel Clearing Agent and Mounting Medium to replace Chloral Hydrate Solution for use in Microscopy, Forensics, Quality Control, Education, and Biological, Food, and Earth Sciences microscopic view of the upper epidermis underlying palisade cells of mate leaves (Ilex paraguariensis ) treated with a VisikolTM solution (right) was clearer than that of cells treated with an acidified chloral hydrate glycerol solution (left).Invention Summary:Rutgers scientists have identified a novel chemical solution, VisikolTM, for clearing and mounting tissues for microscopic identification. The newly identified chemical solution is constituted of chemical compounds that have never been used for such applications. Visikol can be used as a replacement for the universally used clearing...Fri, 31 May 2013 11:22:21 GMTchristopher.perkins@rutgers.edu University Scarlet Knight™ Cranberries, 31 May 2013 11:22:13 GMTchristopher.perkins@rutgers.edu Microbead-Based Microfluidic Platform for Point-of-Care Analyte Detection of a possible embodiment of the described microfluidic platform. The incubation spiral allows for longer sample incubation, while magnetic microbeads are used to facilitate sophisticated manipulation of the target analyte.Invention Summary:Lab-on-a-chip (LOC) devices are designed to perform sample processing and analyte detection in a single microfluidic device. Typically, LOC assays are faster, require smaller sample volumes, and cost less than their conventional counterparts. Further, because LOC devices are designed to work without external equipment, they can be used in point-of-...Fri, 31 May 2013 11:22:12 GMTchristopher.perkins@rutgers.edu Spartan Holly Summary:Spartan is a new and distinct variety of evergreen holly distinguished in that it combines from three species (Ilex rugosa, Ilex integra, and Ilex pernyi), and has desirable landscape and production traits which distinguish it from all other forms of Ilex. Plants typically attain a size to 2.13 m in height and 1.37 m in width in 10 years under conditions of minimal fertilization and supplemental irrigation. Under more optimal conditions, more vigorous growth (approximately 20 to 25 centimeters per year) can be achieved. A plant in the mature phase (flowering) can be achieved ...Fri, 31 May 2013 11:22:11 GMTchristopher.perkins@rutgers.edu and Methods for Generating Three-Dimensional Images from Two-Dimensional Bioluminescence Images and Visualizing Tumor Shapes and Locations up projection plane geometry for images taken from different views. (a) some example views for consecutive images. (b) all views forming a full circle.Invention Summary:Bioluminescence imaging (BLI) is an emerging technique for sensitive and non-invasive imaging, which can be used for monitoring molecular events in living animals. Important applications of this technique include gene therapy and cell trafficking studies. Recent research has focused on bioluminescence tomography (BLT) in an effort to extract depth information from 2D bioluminescence images. Such efforts, however, have b...Wed, 22 May 2013 08:34:43 GMTchristopher.perkins@rutgers.edu Stem Cell Gene Expression and Behaviors by Nanotopography-Mediated siRNA/DNA Delivery, 15 May 2013 08:38:24 GMTchristopher.perkins@rutgers.edu Stem Cell Differentiation by Light-Responsive Hydrogel Summary:The ability of stem cells to differentiate into specialized lineages is vital for regenerative medicine. It is known that the stem cell microenvironment plays a major role in controlling various stem cell behaviors. Rutgers scientists have developed a novel light-responsive hydrogel-based platform that employs three-dimensional micro-scale patterns to modulate microenvironment signals for the control of human stem cell differentiation. This system combines fundamental principles from chemistry, materials science and engineering to afford control over physical (i.e. pattern ge...Wed, 15 May 2013 08:37:43 GMTchristopher.perkins@rutgers.edu Proanthocyanidin Extract Effective at Inhibiting Adherence of Bacteria with P-type Fimbriae to Surfaces Bacterial Anti-Adhesion Activity of A-type Proanthocyanidins. Right: Cranberry (Vaccinium macrocarpon)Invention Summary:Rutgers scientists have isolated and identified unique A-type plant proanthocyanidin extracts that are useful for prevention of bacterial adhesion caused by P-fimbriated Escherichia coli or other microorganisms containing structurally-related fimbriae or molecules involved in microbial adherence. Adhesion is the initial step in development of urinary tract and other bacterial infections. While such extracts can be obtained from a variety of proanthocyanidin-containing p...Wed, 15 May 2013 08:32:21 GMTchristopher.perkins@rutgers.edu Phase Selective Sorbent Xenogels for Oil Spill Containment, 08 May 2013 06:29:56 GMTchristopher.perkins@rutgers.edu Approach for Inhalation Treatment of Pulmonary (Lung) Fibrosis, 08 May 2013 06:29:40 GMTchristopher.perkins@rutgers.edu for Food and Health Use Our major research and product development areas include: (i) probiotic-derived natural antimicrobials for human health (ii) novel probiotics for traditional and non-dairy applications. We isolated and characterized antimicrobial proteins from the known strain of Lactobacillus sporogenes (Bacillus coagulans) and from a novel strain of Bacillus amyloliquefaciens. The antimicrobial peptide subtilosin produced by B. amyloliquefaciens is active against vaginal pathogens, has spermicidal activity and kills herpes viruses 1 and 2. It also kills foodborne pathogen Listeria monocytogenes, including ...Mon, 06 May 2013 07:25:04 GMTchristopher.perkins@rutgers.edu MODEL FOR MALIGNANT MELANOMA AND USES THEREOF, 07 Mar 2013 13:33:11 GMTchristopher.perkins@rutgers.edu