Latest technologies from Rutgers the State University of New Jerseyhttp://rutgers.technologypublisher.comBe the first to know about the latest inventions and technologies available from Rutgers, The State University of New Jerseyen-USSat, 17 Feb 2018 11:05:41 GMTTue, 06 Feb 2018 12:34:43 GMT 2018, Rutgers the State University of New JerseyMethod for Sintering Ultrahigh Melting Temperature Covalent Non-oxide Ceramics, 06 Feb 2018 12:34:43 GMTchristopher.perkins@rutgers.edu and Non-Genotoxic Gene Transfer System for Stem Cells, 30 Jan 2018 13:06:46 GMTchristopher.perkins@rutgers.edu Exhaled Breath Condensate (EBC) Analyzer for Asthma Diagnosis and Monitoring Summary: Asthma, an increasingly important global health problem that affects ~ 300 million people worldwide, is characterized by variable airway inflammation and air flow obstruction. Currently available non-invasive methods for diagnosing and monitoring asthma involve measurements of exhaled nitric oxide (NO). Apart from the transient nature of NO, these methods are limited by low sensitivity and an inability to identify the nature and extent of airway inflammation. Measurement of alternative biomarkers in exhaled breath condensate (EBC) that can facilitate molecular phenotyping of...Mon, 22 Jan 2018 08:05:16 GMTchristopher.perkins@rutgers.edu Interferon Fusion Polypeptides as Antiviral and Cancer Therapeutics, 17 Jan 2018 08:24:47 GMTchristopher.perkins@rutgers.edu Click Pill Dispenser Summary: Most pharmaceutical dosing dispensing devices do not allow for single dosing and dose timing to be accessed simultaneously. A researcher at Rutgers has invented a new, compact and easy to use dosing pill dispenser device. It can perform two functions with a single click. To dispense a single dose and simultaneously change the image displayed in the window, a user simply depresses the cap. Depressing the cap changes the position of a roll located within the device. This action causes a new display to appear in the window. The display can be set prior to loading the pills by c...Thu, 11 Jan 2018 13:15:26 GMTchristopher.perkins@rutgers.edu Phosphatidylserine-Targeting Immuno-Biologicals for Cancer and Viral Treatment Biological inhibits tumor growthInvention Summary: Phosphatidylserine (PS) is a phospholipid that is restricted to the inner plasma membrane in healthy cells. In the past decade, the constitutive externalization of PS has been observed in a wide range of solid tumors, and is considered a global immunosuppressive signal akin to other checkpoint inhibitory signals in the tumor environment. Rutgers scientists have developed a series of novel fusion proteins consisting of a PS-targeting domain and an immune-stimulating cytokine domain. The PS-targeting domain can target cancer cells w...Tue, 02 Jan 2018 12:16:19 GMTchristopher.perkins@rutgers.edu Eastern Oysters Triploid oysters (right, 3N) produced from improved tetraploids vs. normal diploid controls (left, 2N).Invention Summary:Rutgers University has been breeding eastern oysters since 1960. Rutgers oyster strains such as HASKIN NEHTM have shown strong to moderate resistance to two diseases (MSX and Dermo). Rutgers also developed tetraploid oysters (with four sets of chromosomes) for the production of triploid oysters (with three sets of chromosomes) that are used for aquaculture. Because of their sterility, superior growth, and improved summer meat quality, triploid oysters, which are produced by...Tue, 02 Jan 2018 10:22:40 GMTchristopher.perkins@rutgers.edu Membrane for Separation and Filtration, 12 Dec 2017 12:48:48 GMTchristopher.perkins@rutgers.edu of p-Xylene by Dehydroaromatization of 3-Methyleneheptane obtained from Ethylene, 04 Dec 2017 12:54:33 GMTchristopher.perkins@rutgers.edu Balance, Mobility, and Fitness Rehabilitation Game (left) working with patient (right) within the VSTEP digital health platformInvention Summary:Restoring balance is critical for patients recovering from stroke, trauma, or joint surgery, as well as patients with other neurologic conditions. Virtual reality provides an opportunity to gamify rehabilitation and improve outcomes.Researchers at Rutgers have developed VSTEP, a digital health platform that addresses balance, mobility, and fitness. Infrared (IR), motion-sensing cameras track the movement of the lower extremities, providing feedback for balance movement training. Simultaneous...Wed, 22 Nov 2017 12:18:30 GMTchristopher.perkins@rutgers.edu Oxide Sedation for the Dental Team (Video and DVD), 11 Oct 2017 10:32:32 GMTchristopher.perkins@rutgers.edu, Bioactive Dental Implants, 15 Sep 2017 10:21:59 GMTchristopher.perkins@rutgers.edu Quick Estimation of Human Arterial Stiffness Using HRV Summary: Cardiovascular diseases (CVDs) are the leading cause of deaths worldwide. Arterial elasticity is an important indicator of existing cardiovascular risks of developing CVDs. Reduced arterial elasticity or increased arterial stiffness is known to be associated with hypertension, myocardial infarction and stroke. Being able to measure changes in arterial elasticity is crucial to the early detection of CVDs and successful treatments of these diseases subsequently. Arterial elasticity can be estimated from pulse transit time (PTT) or pulse wave velocity (PWV) measured by ultrasou...Thu, 31 Aug 2017 09:42:47 GMTchristopher.perkins@rutgers.edu radiative decay rate engineering for stable, phosphorescent emission of blue light radiative and non-radiative decay rate of phosphorescent emitting materials can be tuned by the geometry of the nanostructure (NP).Invention Summary: Blue-emitting, phosphorescent organic light emitting diodes (OLEDs) have high efficiency but low stability. As a result, the less efficient fluorescent materials are typically used in OLEDs to extend device lifetime. Much effort has focused on developing new, phosphorescent materials with increased intrinsic stability. Researchers at Rutgers have instead used an extrinsic approach to increasing stability of blue OLEDs. The presence of photoni...Mon, 28 Aug 2017 12:27:01 GMTchristopher.perkins@rutgers.edu<![CDATA[Novel Quantitative & Objective Analytical Tool for Detecting Neurodevelopmental Delays in Infants]]>, 14 Aug 2017 12:32:55 GMTchristopher.perkins@rutgers.edu Underwater Acoustic Lens Summary: Sending and receiving information below the water surface is important but challenging. Techniques such as Sonar use acoustic waves in water to transmit information. Acoustic metamaterials enable Sonar devices to control, direct and manipulate sound waves for increased functionality and higher efficiency. Specifically, acoustic lens has been developed as a transmissive device designed to refract and focus sound waves. Traditional underwater acoustic lenses only operate at high frequencies greater than 300 KHz, which limits their use in secure underwater communications. Rutge...Mon, 14 Aug 2017 12:10:32 GMTchristopher.perkins@rutgers.edu Quantitative Analytical Tool for Assessing Neurological Functions in Human Subjects, 11 Aug 2017 09:16:26 GMTchristopher.perkins@rutgers.edu Barcoding of Microparticles For Multiplexed Molecular Analysis Summary: Capability of detecting multiple protein and nucleic acid biomarkers is crucial to disease diagnosis and precision medicine. Barcoding of microparticles is one of the most common approaches for enabling multiplexed molecular assays. Although optical and plasmonic methods for barcoding particles have been developed, instrumentations involved are often bulky and expansive, preventing portability. Dr. Javanmard at Rutgers University has developed a novel system for portable, multiplexing biosensing applications. The multiplexing capability is achieved through the use of a newly...Mon, 07 Aug 2017 14:14:55 GMTchristopher.perkins@rutgers.edu Candidates for Autoimmune Diseases: Cell Penetrating Peptides that Inhibit IRF5 Activity, 07 Aug 2017 14:14:22 GMTchristopher.perkins@rutgers.edu, A Newly Identified Gene Target for Improved Plant Growth and Yield in Agricultural Applications knockout plants (Gts-1) displayed faster germination and increased growth compared to wild-type (WT) plants.Invention Summary:Rutgers scientists discovered a new gene Gigantus1 (Gts1) in Arabidopsis thaliana, which significantly influences seed germination, growth and biomass accumulation in plants. The protein product GIGANTUS1 (GTS1) belongs to the WD40 protein superfamily, whose members are key regulators of plant development. Under the same growth conditions, Gts1 -knockout plants germinated faster and had significantly increased growth compared to WT plants (Fig. A on top). They al...Mon, 07 Aug 2017 14:13:46 GMTchristopher.perkins@rutgers.edu Organoid Culture Summary:An organoid is a small three-dimensional (3-D) tissue structure that highly resembles the in vivo organ from which it originated. New technology developed at Rutgers Cancer Institute of New Jersey enables researchers to generate organoids from both normal and cancerous tissues of patients. Using this human organoid culture method, stem cell-derived organoids are generated from human primary tissues at the 80-90% of efficiency within 4 weeks. The resulting organoids are reproducibly maintained up to 3 months and comprise epithelial cells (E-cadherin) and mesenchymal cells (Vim...Mon, 07 Aug 2017 14:13:43 GMTchristopher.perkins@rutgers.edu<![CDATA[Novel Cationic Amphiphiles as Antimicrobial Therapeutics & Additives in Food Packaging, Household, and Personal Care Products]]>, 07 Aug 2017 14:13:41 GMTchristopher.perkins@rutgers.edu NANOSTAR SUBSTRATES FOR SERS SENSING IN THE FEMTOMOLAR REGIME Summary:Raman spectroscopy is a valuable analytical tool that employs vibration patterns for the identification of molecules. However, it is limited due to the low scattering cross section of most Raman active molecules, which leads to low sensitivity. Surface-enhanced Raman spectroscopy (SERS) increases the intensity of Raman signals by leveraging the inherent and unique properties of plasmonic nanoparticles (NPs) hence leading to improved detection limits. This technique can be used in fields including pharmaceuticals, material science, forensics, drug detection, and medicine. Whil...Mon, 07 Aug 2017 14:13:37 GMTchristopher.perkins@rutgers.edu Methods for Enhanced Efficacy of Mesenchymal Stem Cells, 07 Aug 2017 14:13:12 GMTchristopher.perkins@rutgers.edu Novel Biomarker for the Early Detection of Pancreatic Cancer staining of mAb Das-1 against low-risk IPMN (left) and high-risk IPMN (right). Gut. 2014 Oct; 63(10):1626-34; 15(11):1009-16Invention Summary:Pancreatic cancer accounts for 5% of all cancer deaths. Early stages of pancreatic cancer are often asymptomatic. As a result, patients with pancreatic cancer are often diagnosed after the cancer is very advanced, and the 5-year survival rate of the patients is less than 6%. Lots of patients can be saved by early detection and treatment of the precursor lesions of pancreatic cancer, including intraductal papillary mucinous neoplasms (IPM...Mon, 07 Aug 2017 14:12:50 GMTchristopher.perkins@rutgers.edu Method for Large Scale Production of Collagen-like Proteins in Bacteria Summary:Collagens are the major structural proteins in the extracellular matrix of animals and are defined by a characteristic triple-helix structure that requires a (Gly-Xaa-Yaa)n repeating sequence. Collagen is widely used in the cosmetic, medical, and manufacturing industries. Currently, most collagens are derived from animal sources. There has been a growing concern of transmissible diseases from animal to humans. Moreover, current technology cannot standardize the extraction procedures and is still unable to make sequence modifications that could improve or modulate biological p...Mon, 07 Aug 2017 14:11:42 GMTchristopher.perkins@rutgers.edu Genetic Tool to Identify Individuals at Increased Risk for Autism, 07 Aug 2017 14:07:45 GMTchristopher.perkins@rutgers.edu Array for High Density Integration with Low Crosstalk, 07 Aug 2017 14:07:18 GMTchristopher.perkins@rutgers.edu Method to Determine Number of Contributors in a DNA Mixture, 07 Aug 2017 14:07:13 GMTchristopher.perkins@rutgers.edu N- and O-Doped Mesoporous Carbon: Electrocatalysts for Oxygen Reduction Reaction (ORR) Summary:In the face of global problems associated with the lack of sustainable and renewable energy sources and environmental pollutions caused by fossil fuels, fuel cells have long been expected to contribute to the solutions to these daunting problems by helping to produce electricity from fuels such as hydrogen. Unfortunately, the electrodes (both cathode and anode) in many conventional fuel cells are composed of expensive and less earth abundant noble metal platinum, which serves as the electrocatalyst. This remains one of the bottlenecks currently plaguing fuel cells from findin...Mon, 07 Aug 2017 14:07:00 GMTchristopher.perkins@rutgers.edu, Biocompatible Nucleic Acid Delivery System, 07 Aug 2017 14:06:40 GMTchristopher.perkins@rutgers.edu LOW-PHASE-NOISE OSCILLATOR, 07 Aug 2017 14:06:38 GMTchristopher.perkins@rutgers.edu and Biodegradable Films for Effective Prevention of Postoperative Adhesions modulus of polyelectrolyte complex (PEC) films (red) compared to soft tissue and competing materials (blue).Invention Summary:Adhesions often form after surgery, causing chronic abdominal or pelvic pain. Currently available adhesion prevention products form only a physical barrier against adhesions and have undesirable properties, such as brittleness and the inability to function in the presence of blood. Rutgers scientists have developed novel biodegradable and non-toxic polyelectrolyte complex (PEC) films with anti-adhesive and anti-inflammatory properties. These PEC-based films are st...Mon, 07 Aug 2017 14:06:36 GMTchristopher.perkins@rutgers.edu Circuit Building Blocks for SOG and Wearable Electronics Summary:Advanced information technology, such as emerging internet of things (IoT) is facing increasing needs for systems-on-demand capable of task and defect adaptation in real-time at lower cost. High-performance electronic systems combing the state-of-the-art processing logics, memories, and sensors on a single chip is highly desired. The challenge in implementing reconfigurable switching matrix network that can be integrated with various functional subsystems, such as advanced displays and wearable electronics requiring high density, high performance, low power consumption, and l...Mon, 07 Aug 2017 14:06:22 GMTchristopher.perkins@rutgers.edu SILICONE FOAM FOR THE SELECTIVE ABSORPTION OF OIL FROM WATER Summary: Large oil spills (over 100,000 tons) such as the BP Deepwater Horizon spill (in which $20B was spent on cleanup and litigation) are not very frequent. However, in 2011 there were over 10 oil spills that released between 15 to 5,500 tons of oil into water. When an oil spill disaster occurs, oil quickly spreads on the surface of water and thus makes the cleanup an extremely difficult operation. The negative environmental impacts of oil spills are severe and current products and techniques do not provide an adequate solution. Researchers at Rutgers have developed a new absorben...Mon, 07 Aug 2017 14:06:17 GMTchristopher.perkins@rutgers.edu Supplement and Feed Compositions to Reduce the Incidence of Osteochondrosis Dissecans Lesions in Genetically Predisposed Foals dietary supplement formulation was developed based on an analysis of serum NMR data from yearling Standardbred horses with (green dots) and without (blue dots) OCD that showed the clear difference in metabolic profiles between genetically predisposed and unaffected horses.Invention Summary:Rutgers scientists and collaborators at Princeton University have developed a new dietary supplement specifically formulated to reduce the incidence of Osteochondrosis Dissecans (OCD) in genetically predisposed young horses. The dietary supplement was developed based on the results of nuclear magnetic re...Mon, 07 Aug 2017 14:06:15 GMTchristopher.perkins@rutgers.edu and Versatile Copolymers to Promote Wound Healing Summary:Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise for promoting topical and surgical wound healing, as SA is known to reduce local pain and inflammation as well as potentially prevent fibrous adhesion formation by reducing scar tissue. The release is stable over a period of around 10 days, which is the critical window for fibrous adhesion formation. The novel formulation is achieved by copolymerization of salicylic acid-based poly(anhydride-esters) (SAPAE) with poly(ethylene glycol) (PEG). The copolymer with ...Mon, 07 Aug 2017 14:06:12 GMTchristopher.perkins@rutgers.edu, Mineral-based Polymers with Ionic Crosslinks ionomers show characteristic behavior of polymers, including fiber formation (left) and flow (center). However, they have high thermal stability: like silicate glass (top right), inorganic ionomers (bottom right) they do not burn or produce fumes when exposed to flame.Invention Summary:Traditional, carbon-based, organic polymers have many applications, but they rely on petroleum, a limited resource. Additionally, carbon-based polymers have low thermal stability and often release harmful chemicals when they break down.Researchers at Rutgers have developed polymers with inorganic backb...Mon, 07 Aug 2017 14:06:06 GMTchristopher.perkins@rutgers.edu System for High-Level Production of Proteins and Protein Domains, 07 Aug 2017 14:06:02 GMTchristopher.perkins@rutgers.edu Terrain Modeling Diagnostics Software (RTMDx), 07 Aug 2017 14:05:57 GMTchristopher.perkins@rutgers.edu Indentation Method Using Scanning Probe Microscope Summary:Accurate indentation measurement is fundamental to atomic force microscope (AFM)-based material property characterization as the force applied and the indentation generated are the two most important physical variables that must be measured in the characterization process. Large measurement errors occur when the measurement frequency range becomes large (i.e., broadband), or the indentation is measured in liquid on soft materials. Such large measurement errors are generated due to the inability of the conventional method to account for the convolution of the AFM instrument dy...Mon, 07 Aug 2017 14:05:56 GMTchristopher.perkins@rutgers.edu Dual Racetrack Silicon Micro-resonators for Quadrature Amplitude Modulation, 07 Aug 2017 14:05:47 GMTchristopher.perkins@rutgers.edu Rare Earth-Based Biophotonic Composites, 07 Aug 2017 14:05:36 GMTchristopher.perkins@rutgers.edu PLATFORM GAP BRIDGING UNIT Summary:In a recent report sponsored by the New Jersey Department of Transportation, it was found that car/platform gap injuries accounted for 25% of all injuries on NJ TRANSIT Rail lines, including death. Similar findings have been reported by other agencies, including the Long Island Rail Road and the Metropolitan Transit Agency of New York. These results prompted the Federal Railroad Safety Advisory Committee to address the seriousness of the car/platform gap issue. Researchers at Rutgers University have developed an apparatus that dynamically fills the gap between the door sill o...Mon, 07 Aug 2017 14:05:34 GMTchristopher.perkins@rutgers.edu Differential Pump for Oxide Molecular Beam Epitaxy Summary:Flux instability of the evaporation sources is one of the biggest problems in the multi-elemental oxide Molecular Beam Epitaxy techniques. Source oxidation of easily oxidizing elements such as Ca, Sr, Ba, and Ti in an oxidizing ambient leads to their flux instability. Such unstable flux rate is detrimental to precise control of film thickness and composition. The only way to prevent this source reaction from happening is to suppress the pressure of the reactive gas near the evaporation source while maintaining high enough gas pressure near the substrate where the film grows w...Mon, 07 Aug 2017 14:05:27 GMTchristopher.perkins@rutgers.edu Nanoparticle-Based Biosensor for Biomarker Detection and Its Use in Early Diagnosis of Cancer, HIV and Other Diseases SchematicInvention Summary:The detection of biomarker proteins with high sensitivity and selectivity is vital for the early diagnosis of many diseases such as cancer and HIV. Rutgers scientists have developed a reduced graphene oxide encapsulated nanoparticle (rGO-NPs)-based field effect transistor (FET) biosensor for sensitive detection of key disease biomarker proteins including cancer markers. This invention is a FET with a source electrode and a drain electrode distanced apart from each other on a semiconductor substrate, and a gate electrode consisting of a uniform layer of rGO-NPs...Mon, 07 Aug 2017 14:05:21 GMTchristopher.perkins@rutgers.edu ZnO Thin Film Transistor Biosensor with High Sensitivity and Selectivity and selective detection of EGFR in serum. (a) Drain current vs. gate bias plot. (b) Sensitivity plot of the device for pure EGFR and EGFR in serum detection. (c) Sensor schematic.Invention Summary:Various semiconductor devices have been developed for use as biosensors including Ion Sensitive Field Effect Transistors (ISFETs), Organic Field Effect Transistors (OFETs), and nanowire-based FET sensors. However, all of these FET-based devices have drawbacks ranging from high bias voltage, low mobility, low output current, low sensitivity, to complex fabrication processes. Zinc Oxide (ZnO)...Mon, 07 Aug 2017 14:05:18 GMTchristopher.perkins@rutgers.edu<![CDATA[Scalable Multiple Inverse-Diffusion Flame Synthesis of Graphene, Syngas and Liquid Fuel & Fabrication of Diamond-Reinforced Composites]]> A schematic multiple inverse-diffusion flames burner. B) Raman spectrum of the few-layer graphene (FLG) on Ni. C) HRTEM image of the FLG. The bottom right insert shows the electron diffraction pattern of the graphene sheet. The top left insert shows resolution magnified image of the graphitic lattice. Invention Summary:Carbon-based nanostructures and films define a new class of engineered materials that display remarkable physical, photonic and electronic properties. Production methods for making carbon-based nanostructures include ultrahigh vacuum annealing of SiC, and chemical vapor depos...Mon, 07 Aug 2017 14:05:10 GMTchristopher.perkins@rutgers.edu and Apparatus for Virtualizing and Sharing UpLink Bandwidth in Wireless LANs figure shows a single wireless access point emulating multiple virtual access points. Clients from different networks associate with corresponding VAPs though they use the same underlying hardware.Invention Summary:The abundance of wireless devices and the demand for constant connection has been met with the increasing deployment of wireless hotspots. Internet Service Providers (ISPs) aiming to provide the best service, frequently locate hotspots at airports, cafes, and shopping areas. One problem they face is differentiating the quality of services they provide to different users. To addr...Mon, 07 Aug 2017 14:05:09 GMTchristopher.perkins@rutgers.edu for producing jet fuel from food and non-food feedstocks Summary:A number of separate studies have shown that genome-scale flux-balance analysis (FBA) modeling can be useful for the in silico design of engineered strains of microbes that overproduce diverse targets. These engineered strains include Escherichia coli (E. coli) that overproduce lycopene, lactic acid, succinic acid, l-valine, l-threonine, and strains of Saccharomyces cerevisiae that overproduce ethanol. FBA models allow the result of various genetic manipulations strategies to be predicted. As a result, the space of possible genetic manipulations can be computationally searche...Mon, 07 Aug 2017 14:05:05 GMTchristopher.perkins@rutgers.edu Collagen Methacrylamide-Derivatized Hydrogels Summary:Natural material collagen has the benefits of bioactivity, biodegradability, and innate adhesiveness and self-assemble, which allows the material to be injected into a defect of almost any geometry with minimal invasion, and then automatically become a solid to provide a stable matrix but have the limited control of mechanical properties. Rutgers scientist Dr. David Shreiber invented a process for creating type I collagen and methacrylamide (CMA)-based hydrogel, which retains the properties of collagen such as self-assembly, biodegradability, and natural bioactivity. In addit...Mon, 07 Aug 2017 14:05:02 GMTchristopher.perkins@rutgers.edu FLOW ANALYSIS FOR CARDIOVASCULAR DIAGNOSTICS Summary:Following a heart attack or the development of some cardiovascular diseases, the movement of the heart walls during the cardiac cycle may change, which affects the motion of blood through the heart. Currently, valvular blood flow can be monitored using imaging techniques such as Doppler ultrasound or time-series MRI, however, the spatial resolutions of such techniques are poor. In addition, it is not possible to observe the detailed interaction of the blood flow and the endocardial surface of the heart. Therefore, the formation of cardiac thrombus remains difficult to predict...Mon, 07 Aug 2017 14:04:59 GMTchristopher.perkins@rutgers.edu Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases Combined nanocarrier based targeted chemo and gene therapy1. Cellular penetration of naked siRNA (green) and siRNA delivered by nanocarrier (red), 2. Treatment of mice bearing metastatic ovarian cancer. a. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (before treatment), b. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (after treatment).Invention Summary:Rutgers scientists have developed an ovarian tumor-targeted therapeutic delivery system that utilizes a nanocarrier delivery vehicle such as liposome or dendrime...Mon, 07 Aug 2017 14:04:55 GMTchristopher.perkins@rutgers.edu Surface Probes and Quantitative Recognition Arrays, 07 Aug 2017 14:04:52 GMTchristopher.perkins@rutgers.edu Catalysts for Water Oxidation/Water Splitting compounds like LiCo2O4 catalyzes water oxidation at lower over-potental than industry standards (Ir, Ru, Pt, Pd) . The crystal structure determines the electro-catalytic performance, with other structures (layered, cubic) or compositions (AB2O4) more useful at different current densitiesInvention Summary: Development of water oxidation/ oxygen reduction catalysts to replace costly and inefficient platinum group metals in commercial electrolyzers and fuel cells has been an unmet need preventing global development of hydrogen technologies. Researchers at Rutgers University have developed ...Mon, 07 Aug 2017 14:04:46 GMTchristopher.perkins@rutgers.edu and Manufacture of Pharmaceuticals by Impregnation onto Porous Carriers Summary:Rutgers scientists have developed a novel platform of pharmaceutical product development by utilizing fluid bed impregnation (FBI) of API solutions onto porous carriers. Impreg-nation of solutions into porous carriers allows extremely uniform distribution of small amounts of material, which can be used for drug dosage regulation. Currently, the method can be adjusted for drug content as low as 0.1% and as high as 10%, thus spanning the entire range of interest for poorly soluble, highly potent compounds in oral delivery applications. The drug release profile can also be contr...Mon, 07 Aug 2017 14:04:39 GMTchristopher.perkins@rutgers.edu Agents from Leaves of Combretum micranthum (Kinkeliba) 40 and 80 min. following oral glucose challenge, the TPFA treated group had significantly lowered plasma glucose concentrations compared to the control group.Invention Summary:Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum (kinkeliba) and a procedure for the preparation of total piperidine flavan alkaloids (TPFA) that possess anti-diabetic properties.Kinkeliba is a highly regarded medicinal plant in Africa, with roots, bark, fruit and leaves being used. In its native Sub-S...Mon, 07 Aug 2017 14:04:37 GMTchristopher.perkins@rutgers.edu With Controllable Size And Morphology, 07 Aug 2017 14:04:29 GMTchristopher.perkins@rutgers.edu and Compositions for Removing Carbon Dioxide from a Gaseous Mixture structure of 1 showing 1D open channels. Color scheme: Zn: cyan, N: blue, O: red and C: grey. H atoms and DMF are omitted for clarity.Invention Summary:Rutgers researchers have developed a method for separating carbon dioxide from a mixture of gases by way of passing said mixture through a porous polymeric coordination compound. The compound is a three-dimensional network with one-dimensional channels made of Zn metal and two polyfunctional ligands with binding sites conducive to CO2 removal.Market Application:Sequestration of greenhouse gases as related to combating anthropogenic climate ...Mon, 07 Aug 2017 14:04:21 GMTchristopher.perkins@rutgers.edu IMIDAZOLATE FRAMEWORKS FOR KINETIC SEPARATION OF PROPANE AND PROPENE, 07 Aug 2017 14:04:15 GMTchristopher.perkins@rutgers.edu Enriched Black Tea Extract to Increase Physical Performance and Reduce Recovery Time from Intense Exercise had higher average power and peak power of 9 repeated sprint intervals in the black tea extract (BTE) supplementation group as compared to the placebo (no BTE supplementation) group (PLA).Invention Summary: Rutgers scientists have identified a new, high-potency black tea extract composition that enhances physical performance. This composition contains a physiologically acceptable carrier and a ployphenol-enriched tea extract. Human clinical trials involving supplementation with the enriched black tea extract found increased baseline antioxidant status, improved hypothalamic-pituitary-...Mon, 07 Aug 2017 14:04:09 GMTchristopher.perkins@rutgers.edu Vehicle Information Systems and Methods sensor fitted on the side of a car detects parked cars and vacant spaces.Invention Summary:ParkNet is a mobile system comprising vehicles that collect parking space occupancy information while driving by. Each ParkNet vehicle is equipped with a GPS receiver and a passenger-side-facing ultrasonic rangefinder to determine parking spot occupancy. The data is aggregated at a central server, which builds a real-time map of parking availability and could provide this information to clients that query the system in search of parking. Creating a spot-accurate map of parking availability cha...Mon, 07 Aug 2017 14:04:07 GMTchristopher.perkins@rutgers.edu of Kombo Butter Extract and Derived Compounds as Novel Neuroprotective Agents, 07 Aug 2017 14:04:02 GMTchristopher.perkins@rutgers.edu Luminescent Microporous Materials for Fast and Reversible Detection of Trace Vapor of High Explosives Summary:Investigators at Rutgers University have synthesized a microporous material made of metal (Zn) and organic molecules with strong capabilities for detecting trace vapor of high explosives. The highly luminescent material exhibits very fast response and high sensitivity towards nitroaromatic explosive DNT, and plastic explosive taggant, DMNB. Such materials lay the groundwork for developing highly sensitive and highly selective luminescent MMOF-based sensors and sensor arrays. Market Application:Explosive detectionPublic and national securityEnvironmental protectionAdvantages:L...Mon, 07 Aug 2017 14:04:01 GMTchristopher.perkins@rutgers.edu Molding Machine for Just-In-Time Compounding provided by used here under the Creative Commons license ref: Summary:The plastics manufacturing industry compounds one to five percent (1-5%) of pelletized additives into bulk polymer resins to fabricate plastic parts. The process of dispersing and distributing pigments, modifiers, fillers, particles, reinforcing agents, and other various compounds within a polymer matrix for injection molding is difficult. In most cases, twin screw extrusion (TSE) is commonly used ...Mon, 07 Aug 2017 14:03:49 GMTchristopher.perkins@rutgers.edu Brightness Excimer Lamp, 07 Aug 2017 14:03:37 GMTchristopher.perkins@rutgers.edu Zinc Oxide Nanotips with Transparent Conductive Film for Photovoltaic Devices Summary:Researchers at Rutgers University have invented a novel 3-D structure by integrating Zinc Oxide (ZnO) nanotips and ZnO transparent conductive oxide (TCO) film for applications in photovoltaic devices. This novel 3-D structure has multifunctionality with in-situ doping: the ZnO film is heavily doped, acting as the transparent and conductive electrode, while the undoped or less heavily doped single crystalline ZnO nanotips provide n-type semiconductor with nanostructure morphology, acting for anchoring dye and/or polymer molecules. The ZnO nanotips and ZnO TCO film can be grown...Mon, 07 Aug 2017 14:03:07 GMTchristopher.perkins@rutgers.edu, High-strength, Low-Temperature Cure, High-Temperature Resistant Composite Summary:Ceramic composites are popular in applications where materials are expected to encounter high temperatures, i.e. engine components, exhaust systems, and fire barriers. The low density as compared to metals makes them attractive in applications where weight is a critical design parameter. However, most ceramic composites are fabricated using high heat treatment and the operating temperatures are often lower than the temperatures used for the fabrication of the composites. In addition, the production of high-temperature resistant ceramic composites typically involves the use of...Mon, 07 Aug 2017 14:02:54 GMTchristopher.perkins@rutgers.edu Sheet Folding Machine with Microfolding Technology Summary:Folded materials are useful in packaging, sandwich structures, floor boards, car bumpers and other applications where requirements pertaining to shock, vibration, energy absorption, and/or a high strength-to-weight ratio including volume reduction must be met. Folding flat sheets of material into intricate three-dimensional structures may provide a new technology for production of cores and sandwich structures. Currentproduction methods such as stretch-drawing, forging, pressing, casting and fabrication may appear to produce cosmetically similar patterns but the mechanical pr...Mon, 07 Aug 2017 14:02:35 GMTchristopher.perkins@rutgers.edu RE-doped SiO2-base Fluorescent Materials image showing nano-silicate formation in a glassy matrix, after annealing at 1000 oC for 24 hoursInvention Summary:A new class of nanostructured RE-doped SiO2-base materials that display superior fluorescence properties with high gain combined with a broad and flat spectral band with. Such enhanced fluorescence properties have been observed in heat treated nanopowders prepared by vapor-phase, sol-gel and spray-pyrolysis methods. The expectation is that similar effects will be observed in monolithic materials, when known bulk glass processing methods, such as glass-ceramic processing, inc...Mon, 07 Aug 2017 14:01:42 GMTchristopher.perkins@rutgers.edu Butter Extract and Derivatives as Novel Anti-Inflammatory Agents Summary:Rutgers scientists have developed a novel process to isolate the critical bio-active compounds of Kombo butter, which can be used to effectively treat a variety of inflammatory disorders including arthritis/joint or other inflammation (including bowels, gastrointestinal, skin, and allergic), and the presence of associated free radicals. Kombo butter (African nutmeg) has been shown to have various health benefits as a food or diet supplement, with multiple purported benefits. Our scientists have isolated the 3 key functional chemicals critical to anti-inflammatory action of Ko...Mon, 07 Aug 2017 14:01:18 GMTchristopher.perkins@rutgers.edu Agents from Artemisia Plants Summary:Rutgers scientists have discovered that extracts of Artemisia plants, in particular Artemisia dracunculus, could be useful for treating Type 2 diabetes. These extracts can be rapidly and inexpensively obtained in a concentrated form (e.g., powder) by extraction using common mildly polar solvents (e.g., ethanol). Numerous recent publications from the Rutgers team and colleagues at Pennington Biomedical Research Center (Lousiana State University) demonstrated that Russian tarragon (A. dracunculus) extracts modulate blood glucose levels and enzyme/receptor activities involved in...Mon, 07 Aug 2017 14:00:24 GMTchristopher.perkins@rutgers.edu Temperature Formation of Inorganic Conversion Coatings for Ferrous Substrates Summary:Coatings that provide a passivating barrier of very low solubility through a conversion of the metal surface into a corrosion-resistant, non reactive form, play an important role in coating technology. Conversion coatings are often absorbent, providing an ideal base for protective oils, waxes or dyes. They are also used for high-temperature applications and provide properties such as hardness, abrasion resistance, and adhesion and thermal stability. Chromate and phosphate conversion coatings have poor abrasion resistance and thermal stability, and preparation process requires...Mon, 07 Aug 2017 13:58:38 GMTchristopher.perkins@rutgers.edu Doped Nanocomposite Materials for Photonics Applications, 07 Aug 2017 13:58:34 GMTchristopher.perkins@rutgers.edu Thermostable Alpha-Galactosidase for Use as a Flatulence-Reducing Agent, 07 Aug 2017 13:58:17 GMTchristopher.perkins@rutgers.edu Lateral Beam Expander for Mode Size Conversion, 03 Aug 2017 10:35:33 GMTchristopher.perkins@rutgers.edu Non-Membrane Feeding Device And Diet Formulation For Mosquito Colony Production, 25 Jul 2017 05:20:32 GMTchristopher.perkins@rutgers.edu Affirmation Treatment Videos for Young Transgender Patients, 24 Jul 2017 13:00:31 GMTchristopher.perkins@rutgers.edu Room Control Software, 24 Jul 2017 12:46:42 GMTchristopher.perkins@rutgers.edu Lunchbox: An Educational Kit for Teaching the Physics of Light Summary:The Luminescent Lunchbox is an educational tool kit that illuminates the physics of light through exciting experiments with glow-in-the-dark food. The tool kit includes materials and instructions for four exciting lab experiments. The experiments involve the use of light with food and make it fun for students in grades K-12 to learn and understand photophysical concepts such as the electromagnetic spectrum, absorption of light and fluorescence, use of spectrofluorometers to identify the composition of solutions and the use of absorptive filters.The Luminescent Lunchbox includ...Mon, 24 Jul 2017 11:50:44 GMTchristopher.perkins@rutgers.edu Screener for Young Children Summary:Effective screening during the toddler period may lead to timely detection of Autism Spectrum Disorder (ASD). The Autism Screener for Young Children is a Psychological Development Questionnaire. It is a brief parent-report questionnaire designed to represent the expression of social attention, communication and reciprocity in young children and inversely to detect children at-risk for ASD.Details:Researchers at Rutgers University have created a screening instrument comprised of a ten-item parent-report questionnaire. Parents, medical or educational personnel answer questions ...Mon, 24 Jul 2017 11:11:32 GMTchristopher.perkins@rutgers.edu™ I-O: An Economic Impact Model, 24 Jul 2017 10:40:28 GMTchristopher.perkins@rutgers.edu Curriculum to deal with Perinatal Mood Disorder Summary:Perinatal mood disorder includes major and minor depressive episodes that occur during pregnancy or shortly after delivery and is a common medical complication affecting one in seven women. The INSPIRE project at Rutgers University has been created to help women who are suffering with this disorder. A curriculum that uses artistic expression and creative story-telling has been designed for the project that will be used in support groups of new and expecting mothers struggling with the transition to motherhood. The curriculum is designed for use in a larger project which seeks...Mon, 24 Jul 2017 07:49:24 GMTchristopher.perkins@rutgers.edu Dual Cell Therapy for Wound Healing, 21 Jul 2017 09:13:55 GMTchristopher.perkins@rutgers.edu Polyelectrolyte Membranes for Protection against Chemical Warfare Agents of muticatalyst polyelectric membrane (PEM) for protection against chemical warfare agents (CWAs). Polyoxametalate nanoclusters and metal oxide nanoparticles contribute catalytic activityInvention Summary:To protect a wearer from toxic chemicals, such as chemical warfare agents (CWAs), materials must be both permeable to water vapor and impermeable to those CWAs. While developing such materials is a significant engineering challenge, those materials would provide only a physical barrier between the wearer and CWAs. Researchers at Rutgers have developed a selectively permeable polyele...Tue, 16 May 2017 06:11:17 GMTchristopher.perkins@rutgers.edu Novel Vaccine Candidate Against Fungal Infection infected with mutant fungal strain display enhanced inflammatory response and survival A.) Flow cytometric analysis of cellular infiltration in the lungs shows higher number of CD4+ T cells and monocytes for mice infected with live mutant strain. B.) Vaccinated mice (C57BL/6J and A/J) with heat killed mutant strain showed higher survival rate when challenged with wild strain (H99) of fungus.Invention Summary:Invasive fungal infections kill over 1.5 million people worldwide annually. Cryptococcus neoformans, for example is a human fungal pathogen that often causes lung and brain infection ...Fri, 12 May 2017 13:08:13 GMTchristopher.perkins@rutgers.edu Resolution, Real-Time Flatness and Thermal Expansion Metrology of surface curvature measurement and thermal expansion measurement apparatusInvention Summary:During manufacturing of thin films and semiconductors, it is critical to monitor the flatness and thermal expansion of samples to identify and manage stresses. These parameters are currently measured optically based on the deflection of multiple parallel beams, but, this approach is limited in the sample size, resolution, and the distance between the sample and the measurement apparatus.Researchers at Rutgers have developed a novel metrological apparatus to overcome these limitations. Specif...Fri, 12 May 2017 12:51:16 GMTchristopher.perkins@rutgers.edu Computer-Aided Detection of Abnormal Regions in Medical Images operator characteristic curves for detection of prostate cancer at various weights (T) in histological (top) and MRI (bottom) images. Classification is based on multiplicative weighted maximum a posteriori (MWMAP) estimation with iterated conditional modes (ICM). The regions labeled as malignant at three weights are highlighted in green (histology) or red (MRI)Invention Summary:Detection of abnormal features in medical images is a time-consuming task performed by pathologists. Although computer analysis can increase throughput, the size of the images often limits processing speeds. Th...Mon, 17 Apr 2017 06:15:22 GMTchristopher.perkins@rutgers.edu Water Purification Technology for Lead and Heavy Metals, 05 Apr 2017 11:56:12 GMTchristopher.perkins@rutgers.edu Efficient Cancer Drug Delivery Method of siRNA and Erlotinib for synergistic cancer therapyInvention Summary:Combination therapies have been extensively explored in the oncology field, for its potential to improve treatment efficacy, minimize the risks of resistance, and reduce adverse effects. Rutgers researchers have developed a novel drug delivery system for the combined delivery of anti-cancer drug Erlotinib (Tarceva) and nucleic acid molecules (eg. siRNA), which may lead to synergistic treatment effect. This invention utilizes novel cyclodextrin-modified dendritic polyamines (DexAMs) as a vehicle to co-deliver Erl...Wed, 29 Mar 2017 12:24:00 GMTchristopher.perkins@rutgers.edu Pre-Vascularized Scaffold of load-bearing scaffold: osteonal cortical section, porous trabecular section, vascularized osteon, hydroxyapatite columnsInvention Summary:This load-bearing scaffold mimics the native structure of cortical and trabecular bone to improve outcomes of orthopaedic surgeries. The biodegradable, polymeric scaffold has a porous trabecular section surrounded by a cortical section with vertically oriented channels that mimic osteons. Hydroxyapatite columns provide additional structural support to the cortical section, and the scaffold is further mineralized. The osteon-like channels are see...Mon, 27 Mar 2017 13:01:04 GMTchristopher.perkins@rutgers.edu<![CDATA[Stem Cell Growth Matrices with Enhanced Homogeneity, Stemness & Proliferation and Reduced Need for Feeding]]> Summary:There is currently no universal platform or widely accepted technique to efficiently and reproducibly grow stem and progenitor cells (SPCs) in vitro. Stem cells require contact with extracellular matrices as well as signals from growth factors to proliferate and to retain their stemness (preventing their differentiation towards progenitors). Rutgers researchers Dr. Steven Levison and Dr. Nolan Skop have developed a multi-functional scaffold that supports the expansion of neural stem cells and neural progenitors. This scaffold can be adhered to tissue culture plates (Stemtrix ...Fri, 24 Mar 2017 13:38:00 GMTchristopher.perkins@rutgers.edu Use of Brassinosteroids for Muscle Growth, Skin, 20 Mar 2017 12:34:11 GMTchristopher.perkins@rutgers.edu Voltage TFT On Glass For Solar Inverters, 24 Jan 2017 05:46:18 GMTchristopher.perkins@rutgers.edu for Drug-Resistant Bacterial Infections - Myxopyronins, 04 Jan 2017 08:43:54 GMTchristopher.perkins@rutgers.edu for Drug-Resistant Bacterial Infections: Inhibitors of Bacterial RNA Polymerase, 04 Jan 2017 08:24:58 GMTchristopher.perkins@rutgers.edu for Tuberculosis: Novel Inhibitors of Mycobacterial RNA Polymerase, 04 Jan 2017 07:49:48 GMTchristopher.perkins@rutgers.edu Quantitative Assays, 10 Nov 2016 10:53:39 GMTchristopher.perkins@rutgers.edu FISH probes for the prognosis of malignant transformation in Barrett’s epithelium Summary:Studies have reported that patients suffering from BE have a 120-fold higher risk of developing EA. Moreover, most BE patients currently undergo rigorous therapeutic and surgical procedure to alleviate progression to EA. Currently, there are no available methods or tests to predict the progression of BE to EA. It is estimated that the esophageal cancer therapeutics market will grow at a CAGR of 14% to reach $594.7m by 2017.The current standard of care is to treat each high grade BE case as a potential cancer patient. The surgical intervention and aggressive acid suppressive t...Thu, 27 Oct 2016 13:13:09 GMTchristopher.perkins@rutgers.edu Virus/Cell Based Assay for Discovery of Anti-HIV Drugs Summary:Background: Persistence of HIV-1 in latently infected CD4+ T-cells prevents eradication of virus in patients. The half-life of the latently infected population is quite long. To fully eliminate virus, small molecules that can reach and activate latent viral reservoirs could potentially be utilized to eliminate the latent arm of the infection by the combination with current antiretroviral therapy.Invention: This technology is a cell-based assay for high-throughput screening for novel compounds that can activate latent HIV-1. It provides an isolated, latently infected T cell li...Thu, 27 Oct 2016 10:56:48 GMTchristopher.perkins@rutgers.edu<![CDATA[Highly Selective & Rapid Separation of iPSCs from Differentiated Cells]]> Summary:Human induced pluripotent stem cells (iPSCs) hold great promises for disease modeling and drug discovery. However, a rate-limiting step in iPSCs derivation is their separation from differentiated cells. It takes about 10 separations and passages for an iPSC clone to become stable, with minimal differentiation. Traditionally, at every passage, the researchers need to either manually pick the iPSCs from differentiated cells or mechanically scrape the differentiated cells from the plate. As such, for one 6-well plate, an experienced lab researcher typically spends 6-7 hours scra...Wed, 26 Oct 2016 12:14:49 GMTchristopher.perkins@rutgers.edu Molecule Extracellular Inhibitors of TAM Receptors for Cancer Therapy Summary:The TAM receptors (Tyro3, Axl, and Mertk) are a family of three homologous receptor tyrosine kinases (RTKs) that play important roles in tissue homeostasis, immune response, and the resolution of inflammation. Besides the intracellular catalytic kinase domain common to all kinases, the TAMs uniquely contain an extracellular domain that distinguishes them among all known kinases.TAMs are overexpressed in many human cancers, thereby promoting tumor proliferation, migration, survival, and immune escape. TAM dysregulation tracks with more aggressive cancers, poorer predicted pati...Wed, 14 Sep 2016 07:53:17 GMTchristopher.perkins@rutgers.edu RNAi-mediated method for resistance to soybean cyst nematode siRNA-transgenic soybean plants are 40-80% (approx.) more resistant to soybean cyst nematode as compared to the wild type plants (wt). The percentage of reduction in egg number is shown above the bar for each transgenic soybean line.Invention Summary:Rutgers scientists have developed a new method for inducing resistance to soybean cyst nematode (SCN) by using root-specific RNA interference (RNAi) technology.Specifically, RNAi was used to express small RNAs targeting a critical SCN ribosomal gene under the root-specific promoter in soybean plants. Homozygous transgenic soybean plants...Wed, 07 Sep 2016 12:56:25 GMTchristopher.perkins@rutgers.edu Efficiency Isotope Enriched Protein Production Systems Enrichment of Tryptic FragmentsInvention Summary:Rutgers scientists have developed two Single Protein Production (SPP)-based systems to obtain high levels of specific isotopically enriched proteins: an independently inducible system (cSPP(tet)) and an amino acid auxotroph-based dual inducible system. The proprietary SPP system, developed at Rutgers and currently licensed to Takara Bio Inc., essentially turns living E. coli cells into a bioreactor for producing a single protein of interest at high levels. The system utilizes an E. coli endoribonuclease, MazF, to selectively cleave cell...Fri, 12 Aug 2016 12:26:33 GMTchristopher.perkins@rutgers.edu Biosensors for Rapid Determination of Antimicrobial Resistance, 12 Aug 2016 12:04:37 GMTchristopher.perkins@rutgers.edu and Cost-effective Method for Quantifying Nucleic Acid Binding Strength, 21 Jun 2016 11:04:49 GMTchristopher.perkins@rutgers.edu Methionine, Enhanced Protein Corn with a Sturdy Kernel Summary:A multi-faceted invention combining high amino acid enhanced corn with increased kernel hardness, offering nutritional and commercial benefits to breeders, producers, and consumers.Market Application:Animal feedSweet cornPet foodCorn productsAdvantages:Use of corn with increased levels of essential amino acids reduces the need of more costly soybeans and chemically synthesized methi- onine to achieve desired nutrition profiles; it also eliminates the cost of synthetic methionine for feed supplementation. Chemically synthesized methi- onine is also produced as racemic DL-methi...Wed, 15 Jun 2016 13:41:31 GMTchristopher.perkins@rutgers.edu of Field Performance in Woody Perennials Resulting from Engineered Nitrogen Use Efficiency (NUE) Summary:Rutgers scientists have introduced a pine gene for ammonium assimilation (glutamine synthetase [GS]) into poplar resulting in superior field performance including increased height and volume growth compared with non-transgenic controls. The GS transgenics can contribute significantly to strategies for increasing energy biomass production in woody perennials. Our approach to engineering NUE can contribute significantly to strategies for increasing energy biomass production in woody perennials.Market Applications:We believe this technology is applicable not only to increasingly...Wed, 15 Jun 2016 13:32:08 GMTchristopher.perkins@rutgers.edu Venus® Dogwood, 15 Jun 2016 13:19:00 GMTchristopher.perkins@rutgers.edu Bioaerosol Sampler using Ferroelectric Polymer, 20 May 2016 09:16:52 GMTchristopher.perkins@rutgers.edu Diagnostic Tool to Quantify Signatures of Movement in Subjects with Neurological Disorders, Autism and Autism Spectrum Disorders, 16 Mar 2016 10:52:19 GMTchristopher.perkins@rutgers.edu Bug Seizer Attractant and Monitoring System, 11 Mar 2016 10:52:09 GMTchristopher.perkins@rutgers.edu Chiral Biphosphine Metallorganocatalysts for Asymmetric Reactions, 10 Mar 2016 12:06:35 GMTchristopher.perkins@rutgers.edu Synthetic Transcription Factor for Enhanced Gene Expression AuSTF nuclear localization and reporter gene inductionInvention Summary:Rutgers scientists have developed novel gold nanoparticles (AuNPs) functionalized with synthetic transcription factor (STF) components (AuSTF) capable of permeating the plasma membrane, targeting and entering the nucleus, and initiating transcriptional activity of endogenous genes. STFs are comprised of synthetic small molecules and peptides, and can be potentially applied to investigate genome-wide transcriptional cascades, treat or repair malfunctioning signaling cascades within the cell, and guide differentiation or de...Thu, 18 Feb 2016 08:19:01 GMTchristopher.perkins@rutgers.edu Class of Biofertilizer Promoting Growth and Stress Tolerance Summary:Rutgers scientists have identified ACC-deaminase-producing bacterial strains that have advantageous effects on overall plant growth, in particular, turfgrass. Plants infected with ACC-deaminase-producing bacteria are exposed to less ethylene, and thus exhibit better overall growth. Indeed, plants inoculated with these bacteria species and strains were found to have better growth and quality levels and exhibit enhanced resistance to environmental stressors.Market Applications:AgricultureTurfgrassHorticulture BioFertilizer Advantages: Natural biofertilizerNo known side effect/t...Wed, 18 Nov 2015 08:39:39 GMTchristopher.perkins@rutgers.edu Personal Electrostatic Bioaerosol Sampler (PEBS), 14 Oct 2015 08:17:17 GMTchristopher.perkins@rutgers.edu and Biocompatible Bioactive-based Polymers for Dental Applications Summary:The Uhrich group at Rutgers University has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), and antibiotics (e.g., amoxicillin). Bioactive molecules are incorporated into polymer backbones through labile linkages, enabling high bioactive loading and sustained and controlled release upon degradation (e.g., hydrolysis). The release profile is well controlled based on the polymer chemical compositions and can be adjusted to desired release time frame (from hours, days, t...Tue, 18 Aug 2015 13:06:59 GMTchristopher.perkins@rutgers.edu Novel Method for Diagnosing and Monitoring Brain Trauma Patients, 28 Jul 2015 08:43:32 GMTchristopher.perkins@rutgers.edu Humanized Yeast System for mTOR Kinase Inhibitor Screening and Studies, 28 Jul 2015 07:16:42 GMTchristopher.perkins@rutgers.edu Novel Diagnostic Assay for Predicting Patients’ Resistance to mTOR Kinase Inhibitors Summary:Mechanistic Target of Rapamycin (mTOR) is a highly conserved serine/thereonine protein kinase that plays a crucial role as part of two distinct kinase complexes, mTOR1C and mTOR2C, to regulate cell growth and metabolism. Abnormal activation of mTOR has been implicated in the pathogenesis of several cancers, type 2 diabetes, obesity, and neurodegeneration. Numerous mTOR kinase inhibitors are currently in development with several currently be evaluated as anticancer therapy in clinical trials. However, given recent clinical experience with target therapeutics, acquired drug res...Tue, 28 Jul 2015 06:17:22 GMTchristopher.perkins@rutgers.edu™ Botanical-derived Functional Ingredients for Food, Beverages, Nutrition, 10 Jul 2015 09:22:40 GMTchristopher.perkins@rutgers.edu<![CDATA[Nutrasorb™ Botanical Functional Ingredients for Cosmetic, Personal & Skin Care]]>, 10 Jul 2015 09:16:00 GMTchristopher.perkins@rutgers.edu and Biocompatible Bioactive-based Polymers - Versatile Platform Technology, 07 Jul 2015 12:12:45 GMTchristopher.perkins@rutgers.edu Flow Deflector Summary:With the potential to increase wind farm revenue by up to 30%, this invention consists of several aerodynamic elements which can be retrofitted to any existing wind turbine blade. It can be applied to any current or any new wind turbine design. It is passive and does not require any external power to function, the aerodynamic elements are typically shaped as flat plates or thin airfoils, and it can be combined with vortex generators.The deflector has been found to increase power generation by 10% when added to wind turbine blades in recent prototype tests. This translates int...Fri, 15 May 2015 06:41:14 GMTchristopher.perkins@rutgers.edu Promoting Properties of Newly Identified Root Fungi A. panicicola for Agricultural Applications Summary:Rutgers scientists identified a new root endophytic fungal species, Acidomelania panicicola, which significantly increases growth and stress tolerance of different plant species. A. panicicola was identified from switchgrass and other grass roots from the New Jersey Pine Barrens, where the soil content is nutrient poor, acidic, dry and has high levels of toxic soluble aluminum. Functional studies showed that A. panicicola significantly increased the root hair growth in switchgrass, rice and lettuce seedlings under acidic and poor nutrient conditions. In addition, inoculation ...Fri, 24 Apr 2015 12:56:07 GMTchristopher.perkins@rutgers.edu Nutraceutical Compositions containing Phenethylisothiocyanate and their Uses as Anti-Inflammatory Agents paw edema anti-inflammatory assays demonstrated that treatment with PEITC essential oil (PEO) was as quick and effective as treatment with aspirin.Invention Summary:Rutgers scientists have developed proprietary and unique methods for obtaining high yields of phenethyl isothiocyanate (PEITC), a natural glucosinolate derivative known for its cancer preventive and antiinflammatory properties, from plant tissues (e.g., seeds). After evaluating various plant species and tissues for their PEITC content, it was found that the seeds of Barbarea verna (also known as early winter cress or upland cre...Mon, 23 Feb 2015 11:18:14 GMTchristopher.perkins@rutgers.edu Adaptor: Demonstrated In Vivo Potency and Low Toxicity Provide Clear Advantages for a Next-Generation Gene Silencing Technology in Life Science Research Summary:Rutgers scientists have developed compositions of single-stranded oligonucleotides that inhibit RNA biosynthesis by a novel mechanism of action. This enables the development of highly efficient gene silencing agents that have shown unprecedented inhibitory levels both in vitro and in vivo. The U1 adaptor consists of two parts, a target-gene binding domain and a U1 domain that attracts and inhibits the cellular polyA-tail addition apparatus. By combining both capabilities in the same molecule, the U1 adaptor can specifically inhibit the pre-mRNA maturation step of polyA-tail a...Fri, 13 Feb 2015 13:17:46 GMTchristopher.perkins@rutgers.edu Beacons Summary:Molecular beacons are single-stranded oligonucleotide hybridization probes that form a stem-and-loop structure. The loop contains a probe sequence that is complementary to a target sequence, and the stem is formed by the annealing of complementary arm sequences that are located on either side of the probe sequence. A fluorophore is covalently linked to the end of one arm and a quencher is covalently linked to the end of the other arm. Molecular beacons do not fluoresce when they are free in solution. However, when they hybridize to a nucleic acid strand containing a target se...Wed, 30 Jul 2014 13:35:14 GMTchristopher.perkins@rutgers.edu PERCUTANEOUS VENTRICULAR ASSIST DEVICE, 30 Jul 2014 13:35:11 GMTchristopher.perkins@rutgers.edu Diagnostics of Tick-borne Diseases, 28 Jul 2014 06:45:59 GMTchristopher.perkins@rutgers.edu FOR DIAGNOSING, PREVENTING, AND TREATING DEVELOPMENTAL DISORDERS DUE TO A COMBINATION OF GENETIC AND ENVIRONMENTAL FACTORS Summary:Schizophrenia is a developmental disorder caused by brain damage in a fetus due to maternal genetic and environmental factors. The genetic factors have not been definitively identified due to several factors: 1) involvement of more than one gene 2) uncertainty in the mode of inheritance 3) a high frequency of the allele being tested in the population being screened. The environment around the developing fetus is contributed by maternal components and there is a growing appreciation that a combination of fetal environmental and maternal genetic factors during the second trimes...Thu, 10 Jul 2014 09:13:46 GMTchristopher.perkins@rutgers.edu Unmanned Vehicle Operational in Air and Underwater, 10 Jul 2014 06:56:58 GMTchristopher.perkins@rutgers.edu MORPHOGENETIC PROTEIN-2 AND BONE MORPHOGENETIC PROTEIN-4 IN THE TREATMENT AND DIAGNOSIS OF CANCER Summary:BMP-2 expression is linked to cancer invasion and. BMPs are synthesized as inactive proteins of variable length. The precursor BMP-2 and BMP-4 proteins are proteolytically cleaved, producing mature C-terminal proteins of a little more than 100 residues. BMP-2 and BMP-4 interact with the same binding sites: mature BMP-2 and BMP-4 protein signaling is mediated by transmembrane serine/threonine kinases called type IA, IB, and type II receptors. The receptor phosphorylates cytoplasmic targets, which include the Smad family of proteins. In addition, the same molecules including no...Mon, 07 Jul 2014 11:44:10 GMTchristopher.perkins@rutgers.edu GROWTH FACTOR INDUCIBLE NEUROKININ-1 GENE, 07 Jul 2014 11:44:09 GMTchristopher.perkins@rutgers.edu for Nkx3.1 in prostate development and cancer Summary:Relatively little is known about the molecular mechanisms involved in prostate carcinogenesis due to the lack of animal models that mimic human prostate carcinoma. Mutant mouse models lacking genes critical for prostate development could be utilized to understand the molecular pathways involved in prostate cancer initiation and progression. Also, very few tumor suppressor genes have been definitively shown to be lost during prostate cancer progression. Thus, the identification of prostate-specific tumor suppressor genes would be extremely valuable in studying prostate carcino...Mon, 07 Jul 2014 11:44:07 GMTchristopher.perkins@rutgers.edu AND PROTECTION AGAINST GLUCOCORTICOID INDUCED CELL DEATH IN BONE CELLS, 02 Jul 2014 13:57:30 GMTchristopher.perkins@rutgers.edu and Therapeutic uses of Topors, a possible Tumor Suppressor Gene, 02 Jul 2014 13:56:36 GMTchristopher.perkins@rutgers.edu methods for protein profiling, 02 Jul 2014 11:41:27 GMTchristopher.perkins@rutgers.edu Isoform and Diagnostic and Therapeutic Uses Therefor, 02 Jul 2014 11:41:26 GMTchristopher.perkins@rutgers.edu Safety Syringe Summary:As per OSHA estimates, 5.6 million workers in the health care industry are at risk of exposure to bloodborne pathogens, including human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) due to needlestick injuries. About 600,000 to 800,000 needlestick injuries occur annually among healthcare workers and this remains an important concern and represents significant financial burden to healthcare. A large number of these injuries can be prevented by engineering syringe safety mechanisms. The current invention provides a disposable safety syringe syst...Wed, 02 Jul 2014 11:41:25 GMTchristopher.perkins@rutgers.edu intervention of chlamydial infection Summary:Chlamydial infection is caused by Chlamydia trachomatis bacterium and is one of the most common sexually transmitted infections worldwide. As per U.S. Centers for Disease Control and Prevention estimates, there are 4 million new cases of Chlamydial infections each year. Chlamydial infection often results in abnormal discharge from female and male sexual organs and pain while urinating. If left untreated, the infection may spread to other organs of the body causing pelvic inflammatory disease (PID) in women and epidydimitis in men, inflamed rectum and inflammation of the eye. ...Wed, 14 May 2014 06:17:20 GMTchristopher.perkins@rutgers.edu A-4 ANALOGUES FOR CANCER THERAPY Summary:Cancer is one of the most common human diseases, and leads to about 12% of all deaths worldwide. Mitotic inhibitors such as paclitaxel, which is a tubulin-binding compound that disrupts the formation of mitotic spindles, are widely used for the treatment of cancer, and have achieved great commercial successes. However, these clinically used anti-tubulin drugs often face severe limitations such as neural and systemic toxicity, multiple side effects, induction of drug resistance, and complex synthetic pathways and isolation methods. Combretastatin A-4 (CA-4) is a potent tubulin...Wed, 14 May 2014 06:17:19 GMTchristopher.perkins@rutgers.edu DERIVED FROM HUMAN MESENCHYMAL STEM CELLS Summary:Adult and embryonic stem cells (ESCs) have been extensively studied for use in regenerative medicine and other clinical applications. While ESCs have the potential to differentiate into any cell they become functionally unstable in vivo and have the potential to develop into tumors. Furthermore, there are ethical issues raised by the use of ESCs. Given these limitations, adult stem cells are being increasingly examined as an alternative source for use in clinical applications. Adult stem cells have been extensively studied for their potential benefits in the treatment of Alzh...Wed, 14 May 2014 06:17:18 GMTchristopher.perkins@rutgers.edu Method to Determine Number of Contributors in a DNA Mixture Summary:Glutamate signaling was once thought to only participate in synaptic transmission and neuronal excitability, however, recent evidence suggests that inappropriate expression of glutamate receptors in non-neuronal cells plays a role in cellular transformation. Drs. James Goydos and Suzie Chen, researchers at Rutgers University, were the first to report on the oncogenic role of metabotropic glutamate receptor 1 (GRM1) in melanoma development and progression. This group demonstrated the presence of excess levels of extracellular glutamate in GRM1 expressing melanoma cells. Given ...Fri, 09 May 2014 11:36:21 GMTchristopher.perkins@rutgers.edu Short Peptide and Its Mimics as Immuno/Inflammatory Modulators, 09 May 2014 11:36:20 GMTchristopher.perkins@rutgers.edu of Thermal Stability of Collagen Triple Helix Summary:Collagens are the major structural proteins in the extracellular matrix of animals, including all vertebrates and invertebrates, and are defined by a characteristic triple-helix structure that requires a (Gly-Xaa-Yaa)n repeating sequence . Collagen is the most widely used biomaterial in a wide variety of biomedical applications including cosmetic surgery, tissue engineering, and drug delivery. For these applications, collagen is usually extracted from animal sources, especially bovines, but there has been a growing concern of transmissible diseases from these sources. Other c...Fri, 09 May 2014 08:53:36 GMTchristopher.perkins@rutgers.edu and System for Transcutaneous Monitoring of Endotracheal tube placement Summary:Intubating a patient always poses a challenge due to the anatomy of the throat. Most often the tube is inserted into the esophagus by mistake. Insertion of an endotracheal tube into the trachea requires a skilled practitioner and direct visualization that requires the use of a laryngoscope. After the insertion of the laryngoscope into the mouth, the neck of the patient needs to be extended so the inlet of the trachea can be visualized to navigate the tube directly toward it. The procedure is cumbersome and poses a serious risk for patients with neck injury. Researchers at Rut...Wed, 12 Mar 2014 11:55:30 GMTchristopher.perkins@rutgers.edu for modulating inflammatory responses Summary:Cholesterol is a major component of lipid rafts, which are sphingolipid-enriched planar domains of the cell membrane. Rafts play key roles in a variety of the cell signals processes including calcium entry into cells, which activates white blood cells and causes inflammation. Many inflammatory cell responses are tightly controlled by the regulated entry of Ca 2+ ions into the cells. Because innate immune cells lack voltage-gated calcium channels, their response to G-protein coupled (GPC) mediators depends in a great measure on store-operated calcium entry (SOCE) into the cell...Wed, 12 Mar 2014 11:55:30 GMTchristopher.perkins@rutgers.edu OF TREATING AUTISM Summary:DHA is the major brain lipid. Recent studies by several groups of investigators have shown that DHA is the parent molecule for a large number of intracellular and extracellular messengers. Chronic perturbation of the pathways regulated by these molecules could account for the subtle behavioral effects seen with neurological diseases. Oxidation of DHA gives rise to a series of non-enzymatically produced analogs of the enzymatically derived products (neuroprostanes). Since the structure and chemistries of these neuroprostanes are so similar to the enzymatically-produced compoun...Mon, 10 Mar 2014 07:33:55 GMTchristopher.perkins@rutgers.edu to Modulate the Immune System Using Mesenchymal Stem Cells, Cytokines and Chemokines, 05 Mar 2014 09:03:24 GMTchristopher.perkins@rutgers.edu and methods for the treatment and prevention of infections caused by Staphylococcus Aureus Bacteria Summary:The Gram-positive bacterium staphylococcus aureus is a major human pathogen, which causes numerous infections including acute skin abscesses and invasive infections, as well as life-threatening bacteremias and endocarditis. S. aureus is the leading cause of hospital-acquired infections and a major pathogen in nosocomial infections, in infections in patients with indwelling medical devices and in infections of wounds. The Federal Centers for Disease Control and Prevention estimates that in 2006 one in 22 hospitalized patients will experience a hospital-acquired infection, resu...Wed, 05 Mar 2014 08:27:53 GMTchristopher.perkins@rutgers.edu Cancer Therapy Based On A Telomerase Reverse Transcriptase Variant Summary:Telomeres, the protein-DNA structures located on the ends of eukaryotic chromosomes, are required for chromosome stability during DNA replication. Studies have demonstrated that telomere length may serve to limit the replication potential of cells, hence serve as a barrier to immortalization and carcinogenesis. Telomerase plays a key role in maintaining telomere function and activity by catalyzing telomere replication. In human, telomerase activation is observed in 90% of all tumors. Therefore, telomerase is a bona fide target for development of agents directed to cancer ther...Wed, 05 Mar 2014 08:27:51 GMTchristopher.perkins@rutgers.edu METHOD TO MEASURE IGF TYPE I RECEPTOR AND INSULIN RECEPTOR ISOFORM EXPRESSION Summary:It has been generally accepted that although insulin (IR) and the insulin-like growth factor (IGF-IR) receptor pathways have similar structure and function, they exert different physiological actions in disease and non-disease states. Studies have shown that, in normal states, IR is responsible for mediating downstream targets involved in metabolic functions. In contrast, the IGF-IR mediates the activation of target genes involved in cell growth and differentiation. It has recently become clear that there exists multiple isoforms of signaling receptors, which include hybrid r...Wed, 05 Mar 2014 08:27:50 GMTchristopher.perkins@rutgers.edu GLUTATHIONE S-TRANSFEREASE P1 HAPLOTYPE ACTING IN MOTHERS DURING PREGNANCY MAY INCREASE RISK OF AUTISTIC DISORDER IN HER AFFECTED OFFSPRING, 05 Mar 2014 08:27:49 GMTchristopher.perkins@rutgers.edu OF GSTM1 WITH AUTISM AND ASSAYS AND METHODS BASED THEREON Summary:Autism is a pervasive developmental disorder with diagnostic criteria based on abnormal social interactions, language abnormalities, and stereotyped patterns of behavior evident prior to 36 months of age. Despite its lack of Mendelian transmission, autism is highly genetically determined. Although the vast majority of cases are unrelated to known teratogens, phenotypic expression of autism may be affected by the interaction of environmental factors with multiple gene loci. Oxidative stress could interact with common functional polymorphic variants of genes that protect agains...Wed, 05 Mar 2014 06:56:09 GMTchristopher.perkins@rutgers.edu of Human Endogenous Retrovirus Expression in Cancer and Normal Cells, 25 Feb 2014 08:19:25 GMTchristopher.perkins@rutgers.edu and Easily Recyclable Heterogeneous Nanocatalysts, 07 Feb 2014 11:20:28 GMTchristopher.perkins@rutgers.edu and Partially-Oxidized Metallic Plasmonic Electrodes for Inverted Bulk Heterojunction Photovoltaics Summary:The demand to find novel sources of clean, renewable energy has grown significantly over the past several decades. One promising source of renewable energy is in the form of photovoltaic (PV) cells - devices that convert sunlight into electricity. Traditionally, inorganic semiconducting materials are used to create the p-n junction necessary to achieve the photovoltaic effect; these types of materials, however, are rather difficult to process due to the sensitivity of inorganic semiconductors to impurities. Traditional photovoltaics are limited in the structural flexibility l...Thu, 06 Feb 2014 12:24:41 GMTchristopher.perkins@rutgers.edu Wireless Device Indoor Tracking left screenshot shows a sample healthcare application. Each circle represents the likely location of a wireless device. Various rooms are tagged with healthcare functions, such as waiting, triage and treatment. A patient's progress through the facility can automatically be deduced from the sequence of overlapping regions over time.Invention Summary:This invention presents a novel method for real-time tracking of the 3D position of wireless transmitters in indoor environments. A novel monte-carlo method is used for finding the most likely positions. It provides positioning software and core...Thu, 06 Feb 2014 12:24:07 GMTchristopher.perkins@rutgers.edu<![CDATA[SAFE AND EFFECTIVE TOPICAL MEDICATION (SOLUTION, CREAM & PATCH) TO TREAT CUTANEOUS HEMANGIOMA]]> Summary:Capillary hemangioma is the most common benign tumor of the eyelid/orbit in children and affects up to 2% of infants, over 1.7 million children in USA and over 10 million children worldwide. If not treated promptly, it can cause blindness. Overall, the incidence of cutaneous hemangioma is widely prevalent resulting in physically disfiguring and psychologically disturbing lesions in all age groups affected. Systemic or intra-lesional corticosteroids are commonly used as first line treatment. Alternative treatments include laser photocoagulation, surgical excision and immunomod...Thu, 06 Feb 2014 11:58:52 GMTchristopher.perkins@rutgers.edu VANILLOID CARBAMATES, 06 Feb 2014 11:51:37 GMTchristopher.perkins@rutgers.edu Reconstruction Summary:Magnetic Resonance (MR) imaging has been widely used in medical diagnostics because of its non-invasive manner and excellent depiction of soft tissue changes. Image reconstruction methodologies are vital to many applications in medical imaging. Recent developments in compressive sensing theory show that it is possible to accurately reconstruct the Magnetic Resonance (MR) images from highly undersampled K-space data and therefore significantly reduce the scanning duration. Researchers at Rutgers University have developed a sparsity technique for efficient MR image segmentation...Tue, 04 Feb 2014 06:55:29 GMTchristopher.perkins@rutgers.edu Screen Battery for Emission Control of the ESBEC systemInvention Summary:Electrostatic Screen Battery for Emission Control (ESBEC) is a device for capturing airborne particulate matter emissions from a variety of mobile and stationary sources, such as diesel engines used in automobiles, marine engines, agricultural equipment, power generation equipment, etc. The ESBEC collects and allows for subsequent removal of collected airborne particulate matter using a wire mesh screen coated with superhydrophobic material and supplied with high voltage. The superhydrophobic coating on the screen surface enables easy removal of ...Tue, 04 Feb 2014 06:55:15 GMTchristopher.perkins@rutgers.edu Airborne Contaminant Collector: Very High Concentration Rate and Low Power Consumption, 04 Feb 2014 06:55:08 GMTchristopher.perkins@rutgers.edu Causes Accumulation of Amyloid Beta Oligomers in a New Animal Model of Alzheimer's Disease Neuropathology, 22 Jan 2014 11:46:03 GMTchristopher.perkins@rutgers.edu to Predict the Response of Individual Patient to Cocktails of Radiopharmaceuticals, Chemotherapeutics, or Other Agents pictures showing wide variation in cellular uptake of radiopharmaceuticals.Invention Summary:A number of therapeutic cocktails have been developed to treat various diseases including metastatic cancers. However, patients vary widely in their beneficial responses to such therapies. It has been found that the uptake of targeted therapeutic agents by diseased cells varies dramatically even under ideal conditions. Accordingly, treatment with a single pharmaceutical is not likely to target all cells adequately to achieve the desired therapeutic outcome. To increase treatment effectiv...Wed, 22 Jan 2014 11:38:30 GMTchristopher.perkins@rutgers.edu Nucleic Acid (PNA) Conjugates as Antiviral Agents, 22 Jan 2014 11:31:19 GMTchristopher.perkins@rutgers.edu METHOD FOR MAPPING 3' ENDS OF TRANSCRIPTS AND QUANTITATIVE ANALYSIS OF ALTERNATIVE POLYADENYLATION ISOFORM AND GENE EXPRESSION, 22 Jan 2014 11:24:05 GMTchristopher.perkins@rutgers.edu POLYADENYLATION ISOFORMS AS A BIOMARKER TO DETERMINE THE CELL PROLIFERATION AND DIFFERENTIATION STATE, 22 Jan 2014 11:23:35 GMTchristopher.perkins@rutgers.edu RNA Restriction Enzymes, 22 Jan 2014 11:21:48 GMTchristopher.perkins@rutgers.edu AND EXTRACTS THEREOF AS ANTI-HCV INHIBITORS (Merged w/2012-099) Summary:Hepatitis C Virus (HCV) is an RNA virus causing persistent liver infections that can progress to chronic hepatitis, cirrhosis, and in some cases cancer of the liver. With an estimated 170-200 million people infected with HCV worldwide, HCV infection has become a major public health concern both in developed and developing countries. Current therapies against HCV with their adverse side effects, are not only expensive and limited in efficacy against the various HCV genotypes, but also give rise to mutant viruses. Therefore, there is an urgent need for developing improved antiv...Wed, 22 Jan 2014 11:19:27 GMTchristopher.perkins@rutgers.edu Sensor Radio Scene Analysis for Packet Based Radio Signals Using 2nd and 4th Order Statistics Summary:Most existing wireless systems use static allocation of the radio spectrum with each system operating in a predefined fixed frequency band. Since the allocated spectrum is not used at all locations and at all times, this static allocation leads to creation of spectrum holes, which implies inefficient utilization of the available radio spectrum. Dynamic spectrum allocation offers a much more optimal spectrum utilization scheme. However, dynamic systems must have a completely new feature embedded in them, spectrum sensing capability. Spectrum sensing can be defined as RF signal...Thu, 09 Jan 2014 10:15:46 GMTchristopher.perkins@rutgers.edu Biomaterials Portfolio Hydroxyapatite, HAp, chemical formula Ca10 (PO4)6(OH)2 has attracted the attention of researchers over the past thirty years as an implant material because of its excellent biocompatibility and bioactivity. HAp has been used extensively in medicine for implant fabrication. It is commonly the material of choice for fabricating dense and porous bioceramics. Its general uses include biocompatible phase-reinforcement in composites, coatings on metal implants and granular all for direct incorporation into human tissue. Other potential nonmedical applications include a packing material/support for ...Mon, 06 Jan 2014 13:23:44 GMTchristopher.perkins@rutgers.edu Actuator Array Technology for Propulsion, and Flow Control for Underwater Vehicles Summary:Nano Electrokinetic actuators are a novel propulsion method for underwater vehicles. Of significant relevance is the ability to create faster more maneuverable underwater vehicles. These novel actuators operate on a fundamentally different principle from the traditional actuator technologies used to date. The technology takes advantage of electro-osmosis to enable fluid pumping using electric fields. The application is extensively used in micro fluidic devices. Researchers at Rutgers University have developed a new class of fluid micro/nano actuators with superior performance...Mon, 23 Dec 2013 05:45:33 GMTchristopher.perkins@rutgers.edu to Prepare and Apply Flame-retardant Coating Composed of Polyurethane, Isopropyl Alcohol and Magnesium Hydroxide Suspension Summary:In the past, fire proofing plastic involved embedding flame retardant particles directly into the resin matrix. The technique is fine for materials which are not meant to bear loads. However, the amount of flame-retardant particles needed to be effective in higher mass objects is problematic do to the disruption of the networks within a plastic. Therefore, embedded particles are suitable for thinner products, for example casings for electronics and dash boards for cars. However, for structural applications of plastic a different approach must be considered to reduce the threa...Tue, 29 Oct 2013 10:22:04 GMTchristopher.perkins@rutgers.edu Quartz Crystal Microbalance-based Biosensor for Dynamic and Non-invasive Cellular Monitoring Summary:Non-invasive, real-time examination of live cell function is essential in understanding the mechanistic and dynamic progression of biological processes. Existing cell monitoring methods often require removal of cells from the culture environment followed by fixation and labeling, which can be a slow and tedious process. Researchers at Rutgers University have developed a new technology to non-invasively monitor biological cell dynamics associated with cell growth and cell death. More specifically, they have developed Zinc Oxide (ZnO)-nanostructured biosensors that include Quar...Wed, 18 Sep 2013 10:09:07 GMTchristopher.perkins@rutgers.edu Probe Photocurrent Measurement Device Summary:Photocurrent action spectra or external quantum efficiency (EQE) measurement of semiconductor thin films is an important parameter for solar cell development. Values higher than 80% photon to electron conversion efficiency over a broad range of wavelengths are necessary (but not sufficient) condition for the development of highly efficient solar cells. However, this measurement is usually performed on the actual solar cells, meaning the knowledge occurs once the final device is assembled which makes this important measurement burdensome and time consuming. It would be very de...Wed, 18 Sep 2013 10:09:05 GMTchristopher.perkins@rutgers.edu Stellar Pink® Dogwood, 19 Jul 2013 05:41:20 GMTchristopher.perkins@rutgers.edu RECOGNITION BIOFEEDBACK Summary:Grasping an object is one of the most fundamental activities of daily living. Unfortunately hand dexterity is usually impaired following stroke or traumatic brain injury. As anyone who has suffered a broken bone will attest, the lack of usage of the appendage leads to muscular atrophy. The lack of usage also tends to impede recovery; therefore, grasp training and usage of the muscle groups is a high priority for rehabilitation of the upper limbs. Researchers at Rutgers University have developed a rehabilitation device for improving fine motor function in persons with brain in...Sat, 13 Jul 2013 11:21:16 GMTchristopher.perkins@rutgers.edu of an Insect-Growth Regulator for Mosquito Management Summary:Rutgers scientists have developed an insecticide (e.g, pyriproxyfen) autodissemination station that topically contaminates oviposition-seeking mosquitoes in such a manner that the mosquitoes then bring the active control agent back to their breeding locations for control of container-inhabiting mosquitoes in urban environments, particularly the Asian tiger mosquito. The targeted mosquito is prevalent around the world, infesting all inhabited continents and thirty states, and is a carrier of more than twenty pathogens of public and veterinary health importance, including dengu...Mon, 01 Jul 2013 06:06:07 GMTchristopher.perkins@rutgers.edu University Mullica Queen® Cranberries, 01 Jul 2013 06:05:56 GMTchristopher.perkins@rutgers.edu for Enhancing Anaerobic Degradation of Methyl Tert-butyl Ether (MTBE) and Structurally Related Fuel Oxygenates* The slower degradation of MTBE at higher concentrations of syringate may be due to an inhibitory effect of syringate at higher concentrations.Invention Summary:Methyl tert-butyl ether, a volatile synthetic compound, has been the most frequently used fuel oxygenate which, when used with gasoline, increases octane and reduces combustion emissions. As it is a frequent water contaminant that is difficult to remove by most physical methods, a treatment of fuel-contaminated water is required. Rutgers scientists have discovered a novel method for the anaerobic degradation of MTBE and other relevant...Mon, 01 Jul 2013 06:05:55 GMTchristopher.perkins@rutgers.edu Red Beauty® Holly, 01 Jul 2013 06:05:50 GMTchristopher.perkins@rutgers.edu to Produce Hepatitis C Virus E2 Protein Summary:Rutgers scientists have developed methods to produce and purify the ectodomain of HCV E2, a critical structural protein of the virus that has potential to serve as a vaccine candidate to prevent HCV infection. Efforts to study HCV, and to develop vaccines, have been impaired in part by the inability to produce sufficient quantities of high quality protein due to the complexity of the mature form of E2. The technology developed at Rutgers has overcome this limitation and may provide the critical step towards developing a variety of therapeutic options including vaccines agains...Tue, 18 Jun 2013 12:02:21 GMTchristopher.perkins@rutgers.edu Sodium Benzoate: a Novel Agent for Inhibiting Sunlight-Induced Skin Cancer, 18 Jun 2013 12:02:18 GMTchristopher.perkins@rutgers.edu Myxopyronin Analogs for Broad Spectrum Antibacterial Applications, 18 Jun 2013 12:02:14 GMTchristopher.perkins@rutgers.edu A Controlled Drug Delivery System for Extended Analgesia Summary:Opioid analgesics (e.g., morphine) are widely used for the treatment and management of acute and chronic pain. Morphine has a short half-life with the analgesic effect lasting only 4 to 6 hours. Hence, to maintain the drug at therapeutic levels, bolus doses at fixed intervals (every 4 hours) are administered. Currently available commercial extended-release tablets are successful at maintaining long-term benefits (only up to 24 hours) of morphine without dose escalation. Scientists at Rutgers have chemically incorporated morphine into a biodegradable poly(anhydride-ester) (PAE...Thu, 13 Jun 2013 11:34:57 GMTchristopher.perkins@rutgers.edu Surface Design of Tyrosine-Derived Polycarbonates for Attachment of Biomolecules in Medical Polymers Summary:Rutgers scientists have developed a way to attach biomolecules to 3D tyrosine-derived medical polymers and polymer scaffolds in order to aid in cellular responses in wound healing. When incorporating into scaffolds, these polymers have a novel molecular surface design that tethers biomolecules using biotin (Vitamin H) binding. The addition of biotin to the polymer scaffold does not cause significant change to the properties of the polymer yet allows biomolecules to be efficiently tethered throughout the polymer structure within minutes. Furthermore, the resulting polymer scaf...Thu, 13 Jun 2013 11:34:55 GMTchristopher.perkins@rutgers.edu Peak Tilting/Tracking Solar Arrays, 13 Jun 2013 06:11:31 GMTchristopher.perkins@rutgers.edu Facial Features Using Cluster of Point Distribution Models, 13 Jun 2013 06:11:20 GMTchristopher.perkins@rutgers.edu Diagnostic DNA Arrays for Pathogen Detection and Identification 7 times higher signal intensity was obtained for the dimeric probes D and the dimeric probes with a 10-adenine spacer DA compared to conventional monomeric probes M.Invention Summary:Rutgers scientists have developed a unique and pioneering technology for detection and identification of important pathogens in the form of a macroarray diagnostic technology with enhanced detection sensitivity and small reduction in specificity using repeat sequence probes (dimers). We continue to have positive results and improvements, and believe the next stage will focus on refinement, development of a porta...Tue, 11 Jun 2013 11:09:47 GMTchristopher.perkins@rutgers.edu Variegated Stellar Pink Dogwood, 11 Jun 2013 09:42:45 GMTchristopher.perkins@rutgers.edu TOUCH COMMUNICATION: A TECHNIQUE TO INPUT DATA TO CAPACITIVE TOUCHSCREEN DEVICES Summary:Mobile devices now provide us ubiquitous access to a vast array of media content and digital services. They allow us to access our emails and personal photos, open our cars or our garage doors, pay bills and transfer funds between our bank accounts, order merchandise, as well as control our homes. They arguably now provide the de-facto single sign on access to all our content and services, which has proven so elusive on the web. As we increasingly rely on a variety of such devices, we tend to quickly switch between them and temporarily share them with others causing potential...Tue, 04 Jun 2013 12:41:24 GMTchristopher.perkins@rutgers.edu Versatile Biodegradable, Bioactive-Based Polymers for Cosmetic Applications Rutgers scientists have prepared various biodegradable polymers that chemically incorporate bioactive molecules, such as antioxidants and antimicrobials, in the backbone of the polymers. One such example, salicylic acid, has been widely used in cosmetic and personal care products due to its keratolytic and anti-inflammatory effects. The Uhrich group at Rutgers University has invented these novel polymers, called PolyAspirin, by linking together salicylic acid molecules via a biocompatible linker molecule (Fig 1). The polymers are fully biodegradable, and upon hydrolytic degradation release sa...Tue, 04 Jun 2013 12:40:38 GMTchristopher.perkins@rutgers.edu Diagnostic Tool to Quantify Signatures of Novel Diagnostic Tool to Quantify Signatures of Movement in Subjects with Neurological Disorders, Autism and Autism Spectrum Disorders, 04 Jun 2013 12:40:37 GMTchristopher.perkins@rutgers.edu™: Novel Clearing Agent and Mounting Medium to replace Chloral Hydrate Solution for use in Microscopy, Forensics, Quality Control, Education, and Biological, Food, and Earth Sciences microscopic view of the upper epidermis underlying palisade cells of mate leaves (Ilex paraguariensis ) treated with a VisikolTM solution (right) was clearer than that of cells treated with an acidified chloral hydrate glycerol solution (left).Invention Summary:Rutgers scientists have identified a novel chemical solution, VisikolTM, for clearing and mounting tissues for microscopic identification. The newly identified chemical solution is constituted of chemical compounds that have never been used for such applications. Visikol can be used as a replacement for the universally used clearing...Fri, 31 May 2013 11:22:21 GMTchristopher.perkins@rutgers.edu University Scarlet Knight™ Cranberries, 31 May 2013 11:22:13 GMTchristopher.perkins@rutgers.edu Microbead-Based Microfluidic Platform for Point-of-Care Analyte Detection of a possible embodiment of the described microfluidic platform. The incubation spiral allows for longer sample incubation, while magnetic microbeads are used to facilitate sophisticated manipulation of the target analyte.Invention Summary:Lab-on-a-chip (LOC) devices are designed to perform sample processing and analyte detection in a single microfluidic device. Typically, LOC assays are faster, require smaller sample volumes, and cost less than their conventional counterparts. Further, because LOC devices are designed to work without external equipment, they can be used in point-of-...Fri, 31 May 2013 11:22:12 GMTchristopher.perkins@rutgers.edu Spartan Holly Summary:Spartan is a new and distinct variety of evergreen holly distinguished in that it combines from three species (Ilex rugosa, Ilex integra, and Ilex pernyi), and has desirable landscape and production traits which distinguish it from all other forms of Ilex. Plants typically attain a size to 2.13 m in height and 1.37 m in width in 10 years under conditions of minimal fertilization and supplemental irrigation. Under more optimal conditions, more vigorous growth (approximately 20 to 25 centimeters per year) can be achieved. A plant in the mature phase (flowering) can be achieved ...Fri, 31 May 2013 11:22:11 GMTchristopher.perkins@rutgers.edu and Methods for Generating Three-Dimensional Images from Two-Dimensional Bioluminescence Images and Visualizing Tumor Shapes and Locations up projection plane geometry for images taken from different views. (a) some example views for consecutive images. (b) all views forming a full circle.Invention Summary:Bioluminescence imaging (BLI) is an emerging technique for sensitive and non-invasive imaging, which can be used for monitoring molecular events in living animals. Important applications of this technique include gene therapy and cell trafficking studies. Recent research has focused on bioluminescence tomography (BLT) in an effort to extract depth information from 2D bioluminescence images. Such efforts, however, have b...Wed, 22 May 2013 08:34:43 GMTchristopher.perkins@rutgers.edu Stem Cell Gene Expression and Behaviors by Nanotopography-Mediated siRNA/DNA Delivery, 15 May 2013 08:38:24 GMTchristopher.perkins@rutgers.edu Stem Cell Differentiation by Light-Responsive Hydrogel Summary:The ability of stem cells to differentiate into specialized lineages is vital for regenerative medicine. It is known that the stem cell microenvironment plays a major role in controlling various stem cell behaviors. Rutgers scientists have developed a novel light-responsive hydrogel-based platform that employs three-dimensional micro-scale patterns to modulate microenvironment signals for the control of human stem cell differentiation. This system combines fundamental principles from chemistry, materials science and engineering to afford control over physical (i.e. pattern ge...Wed, 15 May 2013 08:37:43 GMTchristopher.perkins@rutgers.edu Proanthocyanidin Extract Effective at Inhibiting Adherence of Bacteria with P-type Fimbriae to Surfaces Bacterial Anti-Adhesion Activity of A-type Proanthocyanidins. Right: Cranberry (Vaccinium macrocarpon)Invention Summary:Rutgers scientists have isolated and identified unique A-type plant proanthocyanidin extracts that are useful for prevention of bacterial adhesion caused by P-fimbriated Escherichia coli or other microorganisms containing structurally-related fimbriae or molecules involved in microbial adherence. Adhesion is the initial step in development of urinary tract and other bacterial infections. While such extracts can be obtained from a variety of proanthocyanidin-containing p...Wed, 15 May 2013 08:32:21 GMTchristopher.perkins@rutgers.edu Phase Selective Sorbent Xenogels for Oil Spill Containment, 08 May 2013 06:29:56 GMTchristopher.perkins@rutgers.edu Approach for Inhalation Treatment of Pulmonary (Lung) Fibrosis, 08 May 2013 06:29:40 GMTchristopher.perkins@rutgers.edu Compounds for Treatment and Prevention of Cystinuria (Cystine Kidney Stones) Summary:Cystinuria is an autosomal recessive disorder, which involves recurrent formation and excretion of cystine crystals due to poor absorption of the amino acid, cystine. This condition generally affects young adults and there have been few treatments available in the past three decades. Current managment and treatment options involve change in diet, urine alkalinization, and/or a handful of drugs such as thiol therapy with tiopronin and D-Penicillamine. Recently, methyl esters of cystine such as L-cystine dimethyl esters (CDME) were shown to be effective inhibitors of cystine cr...Wed, 08 May 2013 06:29:24 GMTchristopher.perkins@rutgers.edu for Food and Health Use Our major research and product development areas include: (i) probiotic-derived natural antimicrobials for human health (ii) novel probiotics for traditional and non-dairy applications. We isolated and characterized antimicrobial proteins from the known strain of Lactobacillus sporogenes (Bacillus coagulans) and from a novel strain of Bacillus amyloliquefaciens. The antimicrobial peptide subtilosin produced by B. amyloliquefaciens is active against vaginal pathogens, has spermicidal activity and kills herpes viruses 1 and 2. It also kills foodborne pathogen Listeria monocytogenes, including ...Mon, 06 May 2013 07:25:04 GMTchristopher.perkins@rutgers.edu Model for Malignant Melanoma and Uses Thereof, 07 Mar 2013 13:33:11 GMTchristopher.perkins@rutgers.edu