Search Results - Life Sciences

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A Method for Large Scale Production of Collagen-like Proteins in Bacteria
Invention Summary:Collagens are the major structural proteins in the extracellular matrix of animals and are defined by a characteristic triple-helix structure that requires a (Gly-Xaa-Yaa)n repeating sequence. Collagen is widely used in the cosmetic, medical, and manufacturing industries. Currently, most collagens are derived from animal sources. ...
Published: 4/30/2019   |   Inventor(s): Barbara Brodsky, Masayori Inouye, Oleg Mirochnitchenko, John Ramshaw
Keywords(s):  
Category(s): Life Sciences, Biomaterials
Sigma-1 Receptor Antagonists – Non-Addictive Pain Management
Invention Summary:The Sigma-1 receptor (S1R) is a ligand-gated molecular chaperone protein, found in the endoplasmic reticulum and plasma membranes, which modulates mu-opioid and NMDA receptors. S1R antagonists can reduce the amplification of messages coming from pain sensors without impacting non-pain sensors that transmit other types of stimuli. ...
Published: 4/22/2019   |   Inventor(s): Youyi Peng, William Welsh
Keywords(s):  
Category(s): Life Sciences, Therapeutics
Nanoelectronic Barcoding of Microparticles for Multiplexed Molecular Analysis
Invention Summary: Capability of detecting multiple protein and nucleic acid biomarkers is crucial to disease diagnosis and precision medicine. Barcoding of microparticles is one of the most common approaches for enabling multiplexed molecular assays. Although optical and plasmonic methods for barcoding particles have been developed, instrumentatio...
Published: 4/4/2019   |   Inventor(s): Mehdi Javanmard
Keywords(s): Biosensor, Biosensors
Category(s): Life Sciences, Diagnostics, Engineering
An Injectable and Long-Acting Local Anesthetics
Invention Summary: Local anesthetics prevent or relieve pain by interrupting nerve conduction. Even the long-acting local anesthetic agents (e.g., bupivacaine, levobupivacaine, ropivacaine) can only provide analgesia for 4-18 hours. Because of the short duration, local anesthetics often have to be given by repeated injection or continuous infusion....
Published: 4/1/2019   |   Inventor(s): Yuanxiang Tao, Xiaoyang Xu
Keywords(s):  
Category(s): Life Sciences, Therapeutics
New Targeted Gene Therapy for Treatment of LAMA2-Related Muscular Dystrophy
(A) Schematic representation of how the chimeric peptide (αLNNd) replaces the missing subunit to enable laminin polymerization. (B) Staining of polymerized chimeric protein in a mouse model of LAMA2-MD. The construct was injected intra-muscularly via an AAV vector.Invention Summary: Laminins with alpha2 subunit are major basement membrane (BM...
Published: 3/13/2019   |   Inventor(s): Peter Yurchenco
Keywords(s):  
Category(s): Life Sciences, Therapeutics
Prodrugs and ADC Derivatives of Non-Camptothecin TOP1-Targeting Cancer Chemotherapeutics
Schematic Structure of an Antibody-Drug Conjugate (ADC) (en.wikipedia.org)Invention Summary:Topoisomerase 1 (Top1) is an essential enzyme in mammalian cells and is a validated target for the treatment of human cancers. Topotecan and irinotecan (camptothecin analogues) are two FDA approved Top1-targeted drugs. Despite being powerful anticancer drugs...
Published: 3/13/2019   |   Inventor(s): Edmond LaVoie, Ajit Parhi
Keywords(s):  
Category(s): Life Sciences, Therapeutics
Novel Antibacterial Compounds for Oral Care
Effect of CAM reduction in bacterial attachment to hydroxyapatite-coated surfaces relative to control with 100% attachment (i.e. 0% reduction)Invention Summary:Periodontitis and caries are common oral diseases caused by enamel demineralization due to bacterial adhesion to teeth. Introducing a layer to the surface of teeth can inhibit bacterial adhe...
Published: 3/8/2019   |   Inventor(s): Kathryn Uhrich, Jennifer Woo, Jeannette Marine
Keywords(s):  
Category(s): Personal Care, Cosmeceuticals, Life Sciences
Multilayer Stackable Tissue Culture Platform for 3D Co-Culture
Invention Summary: In a native tissue inside an animal, different types of cells co-exist and communicate with one another through the surrounding microenvironment using chemical and mechanical signaling. The lack of technology to recreate such a microenvironment in in vitro models results in either under or over prediction of results using convent...
Published: 3/6/2019   |   Inventor(s): Martin Yarmush, Anil Shrirao, Rene Schloss, Ileana Berrios
Keywords(s):  
Category(s): Life Sciences, Research Tools
New Therapy to Treat Spinal Cord Injury
Treated SCI mice showed significant functional recoveryInvention Summary:Spinal cord injury (SCI) results in permanent disruption to nervous system function. There is no effective treatment to promote recovery of motor function after spinal cord injury currently available on the market. Previous research for SCI treatment was focused on targeting e...
Published: 2/12/2019   |   Inventor(s): Li Cai, Misaal Patel
Keywords(s):  
Category(s): Life Sciences, Therapeutics
A Novel One-handed Cannulation Device
Invention Summary:Intravenous cannulation is routinely performed to provide reliable central venous access for administration of medical therapy. The conventional Seldinger cannulation technique is the mainstay of central line placement, however, it can lead to complications due to multiple steps and the need of changing multiple moving parts with ...
Published: 2/12/2019   |   Inventor(s): Hamid Ehsani-Nia
Keywords(s):  
Category(s): Medical Devices, Life Sciences
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