Search Results - Life Sciences

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IFN-Lambda1 Polypeptides as Antiviral and Anticancer Therapeutics
Invention Summary: Interferons (IFNs) are well known for their potent broad-spectrum antiviral activities. In addition, these pluripotent cytokines can also regulate cell growth and differentiation, tissue homeostasis and angiogenesis, and immune and inflammatory responses in various physiological and pathophysiological conditions. Due to their div...
Published: 6/19/2019   |   Inventor(s): Sergei Kotenko, Grant Gallagher
Keywords(s): Gene Therapy, Infectious Disease/Immunology, Oncology
Category(s): Life Sciences, Therapeutics
Computational Ultrasound for Improved Liver and Kidney Diagnosis
Invention Summary: Transabdominal ultrasound is the one of the most widely used imaging modality for initial imaging of patients diagnosed with liver diseases such as Hepatitis C virus and non-alcoholic fatty liver disease. However, current imaging processes cannot differentiate simple steatosis, nonalcoholic steatohepatitis, and hepatic fibrosis. ...
Published: 6/14/2019   |   Inventor(s): John Nosher, Ilker Hacihaliloglu
Category(s): Diagnostics, Life Sciences
Biocompatible Dendritic Polypeptides for Delivery of Multiple Small-Molecule Therapeutics and siRNAs
Invention Summary: Over the past decade, there has been a tremendous interest in the development of nanoparticle-based drug delivery systems. Among them, dendrimers and polypeptide-based systems have been the most prominent. Dendrimers have certain unique characteristics such as monodispersity, modifiable surface functionality, highly defined size ...
Published: 6/14/2019   |   Inventor(s): Kibum Lee, Prasad Subramaniam, Dipti Barman
Category(s): Life Sciences, Research Tools, Therapeutics
New Targeted Gene Therapy for Treatment of Duchenne Muscular Dystrophy
Invention Summary: Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy. It is a genetic disorder and patients suffering from DMD experience gradual muscle weakness in early childhood and are non-ambulant by 12 years of age. The progressive nature of this disease leads to restrictive pulmonary function, diaphra...
Published: 6/13/2019   |   Inventor(s): Gopal Babu
Category(s): Life Sciences, Therapeutics
Human Normal and Cancer Organoid Culture with Defined Components for Six Different Tissue Types
Invention Summary:An organoid is a small three-dimensional (3-D) cellular tissue structure that highly resembles the in-vivo organ from which it is originated. New technology developed at Rutgers Cancer Institute of New Jersey enables researchers to generate organoids from six different cancer types and normal tissues derived from patients sufferin...
Published: 6/7/2019   |   Inventor(s): Hatem Sabaawy
Category(s): Life Sciences, Research Tools
A Method for Large Scale Production of Collagen-like Proteins in Bacteria
Invention Summary:Collagens are the major structural proteins in the extracellular matrix of animals and are defined by a characteristic triple-helix structure that requires a (Gly-Xaa-Yaa)n repeating sequence. Collagen is widely used in the cosmetic, medical, and manufacturing industries. Currently, most collagens are derived from animal sources. ...
Published: 4/30/2019   |   Inventor(s): Barbara Brodsky, Masayori Inouye, Oleg Mirochnitchenko, John Ramshaw
Category(s): Life Sciences, Biomaterials
Sigma-1 Receptor Antagonists – Non-Addictive Pain Management
Invention Summary:The Sigma-1 receptor (S1R) is a ligand-gated molecular chaperone protein, found in the endoplasmic reticulum and plasma membranes, which modulates mu-opioid and NMDA receptors. S1R antagonists can reduce the amplification of messages coming from pain sensors without impacting non-pain sensors that transmit other types of stimuli. ...
Published: 4/22/2019   |   Inventor(s): Youyi Peng, William Welsh
Category(s): Life Sciences, Therapeutics
Nanoelectronic Barcoding of Microparticles for Multiplexed Molecular Analysis
Invention Summary: Capability of detecting multiple protein and nucleic acid biomarkers is crucial to disease diagnosis and precision medicine. Barcoding of microparticles is one of the most common approaches for enabling multiplexed molecular assays. Although optical and plasmonic methods for barcoding particles have been developed, instrumentatio...
Published: 4/4/2019   |   Inventor(s): Mehdi Javanmard
Keywords(s): Biosensor, Biosensors
Category(s): Life Sciences, Diagnostics, Engineering
An Injectable and Long-Acting Local Anesthetics
Invention Summary: Local anesthetics prevent or relieve pain by interrupting nerve conduction. Even the long-acting local anesthetic agents (e.g., bupivacaine, levobupivacaine, ropivacaine) can only provide analgesia for 4-18 hours. Because of the short duration, local anesthetics often have to be given by repeated injection or continuous infusion....
Published: 4/1/2019   |   Inventor(s): Yuanxiang Tao, Xiaoyang Xu
Category(s): Life Sciences, Therapeutics
New Targeted Gene Therapy for Treatment of LAMA2-Related Muscular Dystrophy
(A) Schematic representation of how the chimeric peptide (αLNNd) replaces the missing subunit to enable laminin polymerization. (B) Staining of polymerized chimeric protein in a mouse model of LAMA2-MD. The construct was injected intra-muscularly via an AAV vector.Invention Summary: Laminins with alpha2 subunit are major basement membrane (BM...
Published: 3/13/2019   |   Inventor(s): Peter Yurchenco
Category(s): Life Sciences, Therapeutics
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