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Biocompatible Dendritic Polypeptides for Delivery of Multiple Small-Molecule Therapeutics and siRNAs
Invention Summary: Over the past decade, there has been a tremendous interest in the development of nanoparticle-based drug delivery systems. Among them, dendrimers and polypeptide-based systems have been the most prominent. Dendrimers have certain unique characteristics such as monodispersity, modifiable surface functionality, highly defined size ...
Published: 6/14/2019   |   Inventor(s): Kibum Lee, Prasad Subramaniam, Dipti Barman
Category(s): Life Sciences, Research Tools, Therapeutics
Human Normal and Cancer Organoid Culture with Defined Components for Six Different Tissue Types
Invention Summary:An organoid is a small three-dimensional (3-D) cellular tissue structure that highly resembles the in-vivo organ from which it is originated. New technology developed at Rutgers Cancer Institute of New Jersey enables researchers to generate organoids from six different cancer types and normal tissues derived from patients sufferin...
Published: 6/7/2019   |   Inventor(s): Hatem Sabaawy
Category(s): Life Sciences, Research Tools
Multilayer Stackable Tissue Culture Platform for 3D Co-Culture
Invention Summary: In a native tissue inside an animal, different types of cells co-exist and communicate with one another through the surrounding microenvironment using chemical and mechanical signaling. The lack of technology to recreate such a microenvironment in in vitro models results in either under or over prediction of results using convent...
Published: 3/6/2019   |   Inventor(s): Martin Yarmush, Anil Shrirao, Rene Schloss, Ileana Berrios
Category(s): Life Sciences, Research Tools
In Vitro Model of Liver Steatosis for Screening of Drug Compounds
The decrease in liver steatosis in hepatocytes cultured in steatosis reducing medium.Invention Summary: Donor livers are frequently rejected due to high intracellular fat content, called steatosis, which increases the risk of primary graft non-function in transplant patients. Because liver transplantation remains the only effective treatment for en...
Published: 9/19/2018   |   Inventor(s): Martin Yarmush, Nir Nativ, Francois Berthiaume, Gabriel Yarmush, Timothy Maguire, Rene Schloss
Category(s): Life Sciences, Research Tools
Novel System for High-Yield Production of Proteins and Protein Domains
Invention Summary:The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expres...
Published: 8/29/2018   |   Inventor(s): Gaetano Montelione, Stephen Anderson, Yuanpeng Huang, Thomas Acton
Category(s): Life Sciences, Research Tools
Self-gettering Differential Pump for Oxide Molecular Beam Epitaxy
Invention Summary:Flux instability of the evaporation sources is one of the biggest problems in the multi-elemental oxide Molecular Beam Epitaxy techniques. Source oxidation of easily oxidizing elements such as Ca, Sr, Ba, and Ti in an oxidizing ambient leads to their flux instability. Such unstable flux rate is detrimental to precise control of fi...
Published: 8/29/2018   |   Inventor(s): Seongshik Oh, Yong Kim
Keywords(s): MBE, Semiconductor
Category(s): Physical Sciences, Engineering, Research Tools
Graphene-Encapsulated Nanoparticle-Based Biosensor for Biomarker Detection and Its Use in Early Diagnosis of Cancer, HIV and Other Diseases
Device SchematicInvention Summary:The detection of biomarker proteins with high sensitivity and selectivity is vital for the early diagnosis of many diseases such as cancer and HIV. Rutgers scientists have developed a reduced graphene oxide encapsulated nanoparticle (rGO-NPs)-based field effect transistor (FET) biosensor for sensitive detection of ...
Published: 8/29/2018   |   Inventor(s): Kibum Lee, Sung Myung, Aniruddh Solanki
Keywords(s): Biomarkers, Biosensor, Cancer, Cancer Biomarkers., Diagnostics, Medical Devices, Oncology
Category(s): Life Sciences, Research Tools
Competitive Surface Probes and Quantitative Recognition Arrays
Invention Summary:Scientists at Rutgers and RAD (a biotechnology start-up) have designed a way to eliminate many false positives in highly sensitive research and diagnostic technologies. Competitive Surface Probes (CSPs) can be integrated into Quantitative Recognition Arrays to both quantify target concentrations and substantially reduce the occurr...
Published: 8/29/2018   |   Inventor(s): Kenneth Breslauer, Leslie Beadling, Jens Volker, William Braunlin
Keywords(s): Bioinformatics, Biosensor, Diagnostics, Microfluidics, Research Applications RT- PCR
Category(s): Life Sciences, Research Tools, Diagnostics
High Brightness Excimer Lamp
Invention Summary:An esteemed Rutgers laser physics professor has developed a miniature high brightness excimer lamp. The high brightness lamp is made of a 0.5 mm inner diameter glass tube and four straps of copper wrapped around the glass tube independently, and separated by a fixed distance. The copper leads serve as the outer electrodes in an &l...
Published: 8/29/2018   |   Inventor(s): Daniel Murnick, Nazieh Masoud
Keywords(s): Fluorescence spectroscopy., Photonics, R&D labs applications: Materials testing, UV-microscopy
Category(s): Physical Sciences, Materials, Research Tools, Engineering
Cell Culture Scale-Up via 3D Bioactive Microcapsule
Encapsulated cell proliferation over 10 days in high speed agitation culture.Invention Summary: Industrial cell culture scale-up is a critical unit operation in biopharmaceutical processes. Culturing adherent cells is particularly challenging, since they can’t simply be cultured in suspension but instead require surface area. Current methods ...
Published: 7/24/2018   |   Inventor(s): Biju Parekkadan, Ayesha Aijaz
Category(s): Biomaterials, Research Tools, Life Sciences
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