Search Results - Therapeutics

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IFN-Lambda1 Polypeptides as Antiviral and Anticancer Therapeutics
Invention Summary: Interferons (IFNs) are well known for their potent broad-spectrum antiviral activities. In addition, these pluripotent cytokines can also regulate cell growth and differentiation, tissue homeostasis and angiogenesis, and immune and inflammatory responses in various physiological and pathophysiological conditions. Due to their div...
Published: 6/19/2019   |   Inventor(s): Sergei Kotenko, Grant Gallagher
Keywords(s): Gene Therapy, Infectious Disease/Immunology, Oncology
Category(s): Life Sciences, Therapeutics
Biocompatible Dendritic Polypeptides for Delivery of Multiple Small-Molecule Therapeutics and siRNAs
Invention Summary: Over the past decade, there has been a tremendous interest in the development of nanoparticle-based drug delivery systems. Among them, dendrimers and polypeptide-based systems have been the most prominent. Dendrimers have certain unique characteristics such as monodispersity, modifiable surface functionality, highly defined size ...
Published: 6/14/2019   |   Inventor(s): Kibum Lee, Prasad Subramaniam, Dipti Barman
Keywords(s):  
Category(s): Life Sciences, Research Tools, Therapeutics
New Targeted Gene Therapy for Treatment of Duchenne Muscular Dystrophy
Invention Summary: Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy. It is a genetic disorder and patients suffering from DMD experience gradual muscle weakness in early childhood and are non-ambulant by 12 years of age. The progressive nature of this disease leads to restrictive pulmonary function, diaphra...
Published: 6/13/2019   |   Inventor(s): Gopal Babu
Keywords(s):  
Category(s): Life Sciences, Therapeutics
Sigma-1 Receptor Antagonists – Non-Addictive Pain Management
Invention Summary:The Sigma-1 receptor (S1R) is a ligand-gated molecular chaperone protein, found in the endoplasmic reticulum and plasma membranes, which modulates mu-opioid and NMDA receptors. S1R antagonists can reduce the amplification of messages coming from pain sensors without impacting non-pain sensors that transmit other types of stimuli. ...
Published: 4/22/2019   |   Inventor(s): Youyi Peng, William Welsh
Keywords(s):  
Category(s): Life Sciences, Therapeutics
An Injectable and Long-Acting Local Anesthetics
Invention Summary: Local anesthetics prevent or relieve pain by interrupting nerve conduction. Even the long-acting local anesthetic agents (e.g., bupivacaine, levobupivacaine, ropivacaine) can only provide analgesia for 4-18 hours. Because of the short duration, local anesthetics often have to be given by repeated injection or continuous infusion....
Published: 4/1/2019   |   Inventor(s): Yuanxiang Tao, Xiaoyang Xu
Keywords(s):  
Category(s): Life Sciences, Therapeutics
New Targeted Gene Therapy for Treatment of LAMA2-Related Muscular Dystrophy
(A) Schematic representation of how the chimeric peptide (αLNNd) replaces the missing subunit to enable laminin polymerization. (B) Staining of polymerized chimeric protein in a mouse model of LAMA2-MD. The construct was injected intra-muscularly via an AAV vector.Invention Summary: Laminins with alpha2 subunit are major basement membrane (BM...
Published: 3/13/2019   |   Inventor(s): Peter Yurchenco
Keywords(s):  
Category(s): Life Sciences, Therapeutics
Prodrugs and ADC Derivatives of Non-Camptothecin TOP1-Targeting Cancer Chemotherapeutics
Schematic Structure of an Antibody-Drug Conjugate (ADC) (en.wikipedia.org)Invention Summary:Topoisomerase 1 (Top1) is an essential enzyme in mammalian cells and is a validated target for the treatment of human cancers. Topotecan and irinotecan (camptothecin analogues) are two FDA approved Top1-targeted drugs. Despite being powerful anticancer drugs...
Published: 3/13/2019   |   Inventor(s): Edmond LaVoie, Ajit Parhi
Keywords(s):  
Category(s): Life Sciences, Therapeutics
New Therapy to Treat Spinal Cord Injury
Treated SCI mice showed significant functional recoveryInvention Summary:Spinal cord injury (SCI) results in permanent disruption to nervous system function. There is no effective treatment to promote recovery of motor function after spinal cord injury currently available on the market. Previous research for SCI treatment was focused on targeting e...
Published: 2/12/2019   |   Inventor(s): Li Cai, Misaal Patel
Keywords(s):  
Category(s): Life Sciences, Therapeutics
Novel Methods for Enhanced Efficacy of Mesenchymal Stem Cells
Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nature Immunology, 2014 Nov; 15(11):1009-16Invention Summary:Clinical studies have shown that treatment with mesenchymal stem cells (MSCs) improves the condition of a number of diseases. It is generally believed that MSC-based therapy not only provi...
Published: 8/30/2018   |   Inventor(s): Yufang Shi, Guangwen Ren, Liying Zhang
Keywords(s):  
Category(s): Life Sciences, Therapeutics
Biodegradable and Versatile Copolymers to Promote Wound Healing
Invention Summary:Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise for promoting topical and surgical wound healing, as SA is known to reduce local pain and inflammation as well as potentially prevent fibrous adhesion formation by reducing scar tissue. The release is stable over a...
Published: 8/29/2018   |   Inventor(s): Kathryn Uhrich, Sabrina Snyder
Keywords(s): Polymers, Wound Healing
Category(s): Life Sciences, Therapeutics
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