Search Results - biomarkers

8 Results Sort By:
Graphene-Encapsulated Nanoparticle-Based Biosensor for Biomarker Detection and Its Use in Early Diagnosis of Cancer, HIV and Other Diseases
Device SchematicInvention Summary:The detection of biomarker proteins with high sensitivity and selectivity is vital for the early diagnosis of many diseases such as cancer and HIV. Rutgers scientists have developed a reduced graphene oxide encapsulated nanoparticle (rGO-NPs)-based field effect transistor (FET) biosensor for sensitive detection of ...
Published: 8/29/2018   |   Inventor(s): Kibum Lee, Sung Myung, Aniruddh Solanki
Keywords(s): Biomarkers, Biosensor, Cancer, Cancer Biomarkers., Diagnostics, Medical Devices, Oncology
Category(s): Life Sciences, Research Tools
METHODS FOR DIAGNOSING, PREVENTING, AND TREATING DEVELOPMENTAL DISORDERS DUE TO A COMBINATION OF GENETIC AND ENVIRONMENTAL FACTORS
Invention Summary:Schizophrenia is a developmental disorder caused by brain damage in a fetus due to maternal genetic and environmental factors. The genetic factors have not been definitively identified due to several factors: 1) involvement of more than one gene 2) uncertainty in the mode of inheritance 3) a high frequency of the allele being test...
Published: 7/10/2014   |   Inventor(s): William Johnson, Edward Stenroos
Keywords(s): Biomarkers, CNS, Genetics
Category(s): Life Sciences, Diagnostics
BONE MORPHOGENETIC PROTEIN-2 AND BONE MORPHOGENETIC PROTEIN-4 IN THE TREATMENT AND DIAGNOSIS OF CANCER
Invention Summary:BMP-2 expression is linked to cancer invasion and. BMPs are synthesized as inactive proteins of variable length. The precursor BMP-2 and BMP-4 proteins are proteolytically cleaved, producing mature C-terminal proteins of a little more than 100 residues. BMP-2 and BMP-4 interact with the same binding sites: mature BMP-2 and BMP-4 p...
Published: 7/7/2014   |   Inventor(s): John Langenfeld
Keywords(s): Biomarkers, Oncology
Category(s): Life Sciences, Therapeutics
HEMATOPOIETIC GROWTH FACTOR INDUCIBLE NEUROKININ-1 GENE
Invention Summary:Neurokinin-1 (NK-1) belongs to a family of receptors known to bind neurotransmitters, tachykinins, with different affinities and mediate a range of physiological functions. These receptors are expressed differentially in bone marrow, mammary epithelial cells and neural tissues. While the expression of NK-1 is constitutive in neura...
Published: 7/7/2014   |   Inventor(s): Pranela Rameshwar
Keywords(s): Antibody, Biomarkers, Cardiovascular, CNS, Gene Therapy, Infectious Disease/Immunology
Category(s): Life Sciences
Tropomyosin Isoform and Diagnostic and Therapeutic Uses Therefor
Invention Summary:Tropomyosins are microfilament-associated proteins found in all eukaryotes and have been implicated in autoimmune diseases such as ulcerative colitis. To date, eight different isoforms (hTM1, hTM2, hTM3, hTMsmα, hTM5a, hTM5b, hTM4, and hTM5) have been identified. Although anti-tropomyosin autoantibodies have been detected in...
Published: 7/2/2014   |   Inventor(s): Kiron Das, Jim Jung-Chin Lin
Keywords(s): Antibody, Autoimmune, Biomarkers, Drug Screening, Oncology
Category(s): Life Sciences, Diagnostics
A GLUTATHIONE S-TRANSFEREASE P1 HAPLOTYPE ACTING IN MOTHERS DURING PREGNANCY MAY INCREASE RISK OF AUTISTIC DISORDER IN HER AFFECTED OFFSPRING
Invention Summary:The present invention provides novel markers and assays for autism based on the association of a specific allele with prevalence for having a child or children with autism or autistic disease. The invention relates to the use and application of GSTP1 as a susceptibility marker and teratogenic allele for autism. In addition, the pr...
Published: 3/5/2014   |   Inventor(s): William Johnson, Edward Stenroos
Keywords(s): Biomarkers, Genetics
Category(s): Life Sciences, Diagnostics
ASSOCIATION OF GSTM1 WITH AUTISM AND ASSAYS AND METHODS BASED THEREON
Invention Summary:Autism is a pervasive developmental disorder with diagnostic criteria based on abnormal social interactions, language abnormalities, and stereotyped patterns of behavior evident prior to 36 months of age. Despite its lack of Mendelian transmission, autism is highly genetically determined. Although the vast majority of cases are un...
Published: 3/5/2014   |   Inventor(s): William Johnson, Steven Buyske, George Lambert, Sue Ming, Audrey Mars, Edward Stenroos, Tanisha Williams
Keywords(s): Biomarkers, Genetics
Category(s): Life Sciences, Diagnostics
Novel Microbead-Based Microfluidic Platform for Point-of-Care Analyte Detection
Schematic of a possible embodiment of the described microfluidic platform. The incubation spiral allows for longer sample incubation, while magnetic microbeads are used to facilitate sophisticated manipulation of the target analyte.Invention Summary:Lab-on-a-chip (LOC) devices are designed to perform sample processing and analyte detection in a sin...
Published: 5/31/2013   |   Inventor(s): Jeffrey Zahn, Lawrence Sasso
Keywords(s): Biomarkers, Cardiopulmonary Bypass, Diagnostics, Immunoassay, Immunoassay Monitoring, Inflammation, Microfluidics
Category(s): Life Sciences, Diagnostics