Search Results - cancer

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Graphene-Encapsulated Nanoparticle-Based Biosensor for Biomarker Detection and Its Use in Early Diagnosis of Cancer, HIV and Other Diseases
Device SchematicInvention Summary:The detection of biomarker proteins with high sensitivity and selectivity is vital for the early diagnosis of many diseases such as cancer and HIV. Rutgers scientists have developed a reduced graphene oxide encapsulated nanoparticle (rGO-NPs)-based field effect transistor (FET) biosensor for sensitive detection of ...
Published: 8/29/2018   |   Inventor(s): Kibum Lee, Sung Myung, Aniruddh Solanki
Keywords(s): Biomarkers, Biosensor, Cancer, Cancer Biomarkers., Diagnostics, Medical Devices, Oncology
Category(s): Life Sciences, Research Tools
A Humanized Yeast System for mTOR Kinase Inhibitor Screening and Studies
Invention Summary:mTOR kinase is a highly conserved central regulator of cell growth and metabolism, and a key cancer drug target. Numerous mTOR kinase inhibitors have been developed but have not been approved by FDA. A new screening tool for mTOR kinase inhibitors will facilitate mTOR therapeutic development and related pharmacology studies. Rutg...
Published: 7/28/2015   |   Inventor(s): Steven Zheng
Keywords(s): Cancer, Drug Discovery, Oncology
Category(s): Life Sciences
A Novel Diagnostic Assay for Predicting Patients’ Resistance to mTOR Kinase Inhibitors
Invention Summary:Mechanistic Target of Rapamycin (mTOR) is a highly conserved serine/thereonine protein kinase that plays a crucial role as part of two distinct kinase complexes, mTOR1C and mTOR2C, to regulate cell growth and metabolism. Abnormal activation of mTOR has been implicated in the pathogenesis of several cancers, type 2 diabetes, obesit...
Published: 7/28/2015   |   Inventor(s): Steven Zheng
Keywords(s): Cancer, companion diagnostics, Drug Discovery, Oncology
Category(s): Life Sciences, Diagnostics