Search Results - oncology

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IFN-Lambda1 Polypeptides as Antiviral and Anticancer Therapeutics
Invention Summary: Interferons (IFNs) are well known for their potent broad-spectrum antiviral activities. In addition, these pluripotent cytokines can also regulate cell growth and differentiation, tissue homeostasis and angiogenesis, and immune and inflammatory responses in various physiological and pathophysiological conditions. Due to their div...
Published: 6/19/2019   |   Inventor(s): Sergei Kotenko, Grant Gallagher
Keywords(s): Gene Therapy, Infectious Disease/Immunology, Oncology
Category(s): Life Sciences, Therapeutics
Graphene-Encapsulated Nanoparticle-Based Biosensor for Biomarker Detection and Its Use in Early Diagnosis of Cancer, HIV and Other Diseases
Device SchematicInvention Summary:The detection of biomarker proteins with high sensitivity and selectivity is vital for the early diagnosis of many diseases such as cancer and HIV. Rutgers scientists have developed a reduced graphene oxide encapsulated nanoparticle (rGO-NPs)-based field effect transistor (FET) biosensor for sensitive detection of ...
Published: 8/29/2018   |   Inventor(s): Kibum Lee, Sung Myung, Aniruddh Solanki
Keywords(s): Biomarkers, Biosensor, Cancer, Cancer Biomarkers., Diagnostics, Medical Devices, Oncology
Category(s): Life Sciences, Research Tools
Nanotechnology-based Method for Treatment of Primary Ovarian Cancer and Prevention of Metastases
Two-in-one: Combined nanocarrier based targeted chemo and gene therapy1. Cellular penetration of naked siRNA (green) and siRNA delivered by nanocarrier (red), 2. Treatment of mice bearing metastatic ovarian cancer. a. Mice bearing xenografts of human metastatic cancer and histology of tumor tissue (before treatment), b. Mice bearing xenografts of h...
Published: 8/29/2018   |   Inventor(s): Tamara Minko, Olga Garbuzenko, Oleh Taratula, Lorna Rodriguez-Rust
Keywords(s): Drug Delivery, Oncology, therapeutic, veterinary uses
Category(s): Life Sciences, Therapeutics, Biomaterials
A Humanized Yeast System for mTOR Kinase Inhibitor Screening and Studies
Invention Summary:mTOR kinase is a highly conserved central regulator of cell growth and metabolism, and a key cancer drug target. Numerous mTOR kinase inhibitors have been developed but have not been approved by FDA. A new screening tool for mTOR kinase inhibitors will facilitate mTOR therapeutic development and related pharmacology studies. Rutg...
Published: 7/28/2015   |   Inventor(s): Steven Zheng
Keywords(s): Cancer, Drug Discovery, Oncology
Category(s): Life Sciences
A Novel Diagnostic Assay for Predicting Patients’ Resistance to mTOR Kinase Inhibitors
Invention Summary:Mechanistic Target of Rapamycin (mTOR) is a highly conserved serine/thereonine protein kinase that plays a crucial role as part of two distinct kinase complexes, mTOR1C and mTOR2C, to regulate cell growth and metabolism. Abnormal activation of mTOR has been implicated in the pathogenesis of several cancers, type 2 diabetes, obesit...
Published: 7/28/2015   |   Inventor(s): Steven Zheng
Keywords(s): Cancer, companion diagnostics, Drug Discovery, Oncology
Category(s): Life Sciences, Diagnostics
BONE MORPHOGENETIC PROTEIN-2 AND BONE MORPHOGENETIC PROTEIN-4 IN THE TREATMENT AND DIAGNOSIS OF CANCER
Invention Summary:BMP-2 expression is linked to cancer invasion and. BMPs are synthesized as inactive proteins of variable length. The precursor BMP-2 and BMP-4 proteins are proteolytically cleaved, producing mature C-terminal proteins of a little more than 100 residues. BMP-2 and BMP-4 interact with the same binding sites: mature BMP-2 and BMP-4 p...
Published: 7/7/2014   |   Inventor(s): John Langenfeld
Keywords(s): Biomarkers, Oncology
Category(s): Life Sciences, Therapeutics
Tropomyosin Isoform and Diagnostic and Therapeutic Uses Therefor
Invention Summary:Tropomyosins are microfilament-associated proteins found in all eukaryotes and have been implicated in autoimmune diseases such as ulcerative colitis. To date, eight different isoforms (hTM1, hTM2, hTM3, hTMsmα, hTM5a, hTM5b, hTM4, and hTM5) have been identified. Although anti-tropomyosin autoantibodies have been detected in...
Published: 7/2/2014   |   Inventor(s): Kiron Das, Jim Jung-Chin Lin
Keywords(s): Antibody, Autoimmune, Biomarkers, Drug Screening, Oncology
Category(s): Life Sciences, Diagnostics
COMBRETASTATIN A-4 ANALOGUES FOR CANCER THERAPY
Invention Summary:Cancer is one of the most common human diseases, and leads to about 12% of all deaths worldwide. Mitotic inhibitors such as paclitaxel, which is a tubulin-binding compound that disrupts the formation of mitotic spindles, are widely used for the treatment of cancer, and have achieved great commercial successes. However, these clini...
Published: 5/14/2014   |   Inventor(s): William Welsh, Youyi Peng, Xin Wang, Susan Keenan, Qiang Zhang, Sonia Arora
Keywords(s): Oncology
Category(s): Life Sciences, Therapeutics
Method to Modulate the Immune System Using Mesenchymal Stem Cells, Cytokines and Chemokines
Invention Summary:Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into several types of tissue and are responsible for tissue repair and regeneration. They are highly immunosuppressive. It has been shown that MSCs can suppress T cell proliferation and cytokine production induced by mitogens or properly presented an...
Published: 3/5/2014   |   Inventor(s): Yufang Shi, Guangwen Ren, Liying Zhang
Keywords(s): Infectious Disease/Immunology, Oncology, Stem Cells
Category(s): Life Sciences, Therapeutics
Novel Cancer Therapy Based On A Telomerase Reverse Transcriptase Variant
Invention Summary:Telomeres, the protein-DNA structures located on the ends of eukaryotic chromosomes, are required for chromosome stability during DNA replication. Studies have demonstrated that telomere length may serve to limit the replication potential of cells, hence serve as a barrier to immortalization and carcinogenesis. Telomerase plays a ...
Published: 3/5/2014   |   Inventor(s): Janine Santos
Keywords(s): Autoimmune, Biomaterials, Oncology
Category(s): Life Sciences, Research Tools
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