Search Results - richard ebright

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Therapeutics for Drug-Resistant Bacterial Infections - Myxopyronins
Invention Summary:There is an urgent national and international need for new classes of antibacterial agents effective against bacterial pathogens resistant to current antibacterial agents.Myxopyronin (Myx) is a microbially produced antibiotic that inhibits bacterial RNA polymerase through a novel binding site and novel mechanism. Rutgers researche...
Published: 1/4/2017   |   Inventor(s): Richard Ebright, Juan Shen, James Bacci, William Solvible, Christopher Self, Gary Olson
Keywords(s):  
Category(s): Life Sciences, Therapeutics
Therapeutics for Drug-Resistant Bacterial Infections: Inhibitors of Bacterial RNA Polymerase
Invention Summary:Bacterial infectious diseases kill 100,000 persons each year in the US and 11 million persons each year worldwide, representing nearly a fifth of deaths each year worldwide. For six decades, antibiotics have been our bulwark against bacterial infectious diseases. However, now this bulwark is collapsing. For all major bacterial ...
Published: 1/4/2017   |   Inventor(s): Richard Ebright, Yu Feng, Yu Zhang
Keywords(s):  
Category(s): Life Sciences, Therapeutics
Therapeutics for Tuberculosis: Novel Inhibitors of Mycobacterial RNA Polymerase
Invention Summary:Tuberculosis kills nearly 2 million persons each year. One third of the world's population currently is infected with tuberculosis, and the World Health Organization projects that there will be nearly 1 billion new infections by 2020, 200 million of which will result in serious illness, and 35 million of which will result in deat...
Published: 1/4/2017   |   Inventor(s): Richard Ebright, Yon Ebright, Soma Mandal
Keywords(s):  
Category(s): Life Sciences, Therapeutics
Novel Myxopyronin Analogs for Broad Spectrum Antibacterial Applications
Antibacterial drugs have had a substantive impact in reducing the burden of bacterial infection globally, but bacterial infections remain one of the largest causes of human disease. The widespread emergence of pathogenic bacteria resistant to antibiotics, along with the decline in discovery of new antibacterials is now a serious threat to global pu...
Published: 6/18/2013   |   Inventor(s): Richard Ebright
Keywords(s): Drug Discovery, Metabolic Diseases
Category(s): Life Sciences