Search Results - therapeutics

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Novel Monodisperse PEGtide Dendrons as Nanocarrier for Drug Delivery
Representative Structure of PEGtideInvention Summary: Dentrimers and dendrons have generated tremendous interest as nanocarriers for various drug delivery applications. Rutgers scientists have developed a series of novel monodisperse PEGtide dendrons with versatility to accommodate various drug delivery demands.PEGtide dendrons containing alternati...
Published: 7/24/2018   |   Inventor(s): Patrick Sinko, Jieming Gao
Keywords(s): Diagnostic Imaging, Drug Delivery, Genetic Therapy, Therapeutics
Category(s): Life Sciences, Biomaterials, Therapeutics
U1 Adaptor: Demonstrated In Vivo Potency and Low Toxicity Provide Clear Advantages for a Next-Generation Gene Silencing Technology in Life Science Research
Invention Summary:Rutgers scientists have developed compositions of single-stranded oligonucleotides that inhibit RNA biosynthesis by a novel mechanism of action. This enables the development of highly efficient gene silencing agents that have shown unprecedented inhibitory levels both in vitro and in vivo. The U1 adaptor consists of two parts, a t...
Published: 2/13/2015   |   Inventor(s): Samuel Gunderson, Rafal Goraczniak
Keywords(s): Oligonucleotide, Prophylactics, Research Tool, RNAi, Therapeutics
Category(s): Life Sciences, Therapeutics
Methods to Produce Hepatitis C Virus E2 Protein
Invention Summary:Rutgers scientists have developed methods to produce and purify the ectodomain of HCV E2, a critical structural protein of the virus that has potential to serve as a vaccine candidate to prevent HCV infection. Efforts to study HCV, and to develop vaccines, have been impaired in part by the inability to produce sufficient quantitie...
Published: 6/18/2013   |   Inventor(s): Joseph Marcotrigiano, Jillian Whidby
Keywords(s): Drug Discovery, Hepatitis C, Hepatitis C Target, Peptide Mimetics, Prophylactics, Therapeutics, Vaccines
Category(s): Life Sciences, Therapeutics
Molecular Surface Design of Tyrosine-Derived Polycarbonates for Attachment of Biomolecules in Medical Polymers
Invention Summary:Rutgers scientists have developed a way to attach biomolecules to 3D tyrosine-derived medical polymers and polymer scaffolds in order to aid in cellular responses in wound healing. When incorporating into scaffolds, these polymers have a novel molecular surface design that tethers biomolecules using biotin (Vitamin H) binding. The...
Published: 6/13/2013   |   Inventor(s): Jared Bushman, Joachim Kohn, Jenny Morgan
Keywords(s): Bioengineering Scaffolds, Medical Implants, Polymers., Regenerative Medicine, Therapeutics, Tissue Engineering
Category(s): Life Sciences, Biomaterials, Medical Devices, Therapeutics