A GLUTATHIONE S-TRANSFEREASE P1 HAPLOTYPE ACTING IN MOTHERS DURING PREGNANCY MAY INCREASE RISK OF AUTISTIC DISORDER IN HER AFFECTED OFFSPRING

Invention Summary:

The present invention provides novel markers and assays for autism based on the association of a specific allele with prevalence for having a child or children with autism or autistic disease. The invention relates to the use and application of GSTP1 as a susceptibility marker and teratogenic allele for autism. In addition, the present invention discloses a novel method for identifying individuals who are genetically susceptible to have offspring with autism wherein the genotype of GSTP1, alone or in combination with other genetic markers or other indicators of oxidative stress, is determined.

Market Applications:

GSTP1 may be combined with other markers in methods and assays for monitoring, managing, diagnosis, prenatal diagnosis, and assessment of autism.

Intellectual Property & Development Status:

Published PCT Application: PCT/US2008/003052

Rutgers ID: S07-13
Category(s):
Life Sciences
Diagnostics
Contact:
Yong Zhang
Licensing Manager
848-932-4523
yong.zhang@rutgers.edu
Inventors:
William Johnson
Edward Stenroos
Keywords:
Biomarkers
Genetics