Molecular Surface Design of Tyrosine-Derived Polycarbonates for Attachment of Biomolecules in Medical Polymers


Invention Summary:

Rutgers scientists have developed a way to attach biomolecules to 3D tyrosine-derived medical polymers and polymer scaffolds in order to aid in cellular responses in wound healing. When incorporating into scaffolds, these polymers have a novel molecular surface design that tethers biomolecules using biotin (Vitamin H) binding. The addition of biotin to the polymer scaffold does not cause significant change to the properties of the polymer yet allows biomolecules to be efficiently tethered throughout the polymer structure within minutes. Furthermore, the resulting polymer scaffolds are designed to be biodegradable and tissue compatible.

Market Applications:

  • Therapeutics
  • Tissue Engineering
  • Medical Implants
  • Bioengineering Scaffolds
  • Regenerative Medicine
  • Polymers

Advantages:

  • Increased efficiency of biomolecule tethering reactions
  • Tethering of biomolecules decreased the quantity of biomolecules required, reduces costs of biomolecular supplies, and increases the timetable for biomolecular responses

Intellectual Property & Development Status:

Patent Pending

Select Publications:

  • A. D. Costache, L. Sheihet, K. Zaveri, D. D. Knight and J. Kohn. 2009. Polymer-drug interactions in tyrosine-derived triblock copolymer nanospheres: A computational modeling approach. Mol. Pharmaceutics. 6(5): 1620-1627.
  • R. Rojas, N. K. Harris, K. Piotrowska and J. Kohn. 2009. Evaluation of automated synthesis for chain and step-growth polymerizations: Can robots replace the chemists? J. Polym. Sci: Part A: Polym. Chem. 47(1): 49-58.
  • H. J. Sung, P. Chandra, M. D. Treiser, E. Liu, C. P. Iovine, P. V. Moghe and J. Kohn. 2009. Synthetic polymeric substrates as potent pro-oxidant versus antioxidant regulators of cytoskeletal remodeling and cell apoptosis. J. Cell Physiol.218(3): 549-557.
  • P. F. Holmes, M. Bohrer and J. Kohn. 2008. Exploration of polymethacrylate structure-property correlations: Advances towards combinatorial and high-throughput methods for biomaterials discovery. Prog. Polym. Sci. 33: 787-796.