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Tricyclic Inhibitors of Ribosome‐Inhibiting Proteins
An image that shows p-stalk binding blockage would lead to the prevention of damage caused by Shiga or Ricin toxins
Invention Summary:
Shiga Toxin-producing E. coli (STEC) are very common bacteria that can cause infections that lead to approximately 100,000 illnesses, 3,000 hospitalizations, and about 90 deaths annually in the United States....
Published: 3/31/2025
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Inventor(s): Jacques Roberge, Xiao-Ping Li, Anastasiia Tsymbal, Nilgun Tumer
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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CHIR99021 Loaded Polymeric Scaffolds for the Treatment of Muscle Injuries
CHIR99021 administration reduces adipocyte differentiation (as seen by lipid droplet formation) in adipogenic cultures of stem cells. (A) Oil Red O staining for lipids 14 days after adipogenic induction. (B) Quantification of Oil Red O staining after 14 and 21 days.)
Invention Summary:
The most common injury among athletes are muscle injuries,...
Published: 3/25/2025
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Inventor(s): Doga Oruc, Joseph Freeman
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Additive Manufacturing Using Laser Direct Write with Self-Limiting Electrospray Deposition
A laser consolidates the self-limiting electrosprayed green body allowing for targeting by the spray to create a new layer.
Invention Summary:
Laser direct write is a high precision, maskless laser fabrication technique with wide use in microelectronics, flexible circuits, semiconductor manufacturing, etc. However, material selection is...
Published: 2/25/2025
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Inventor(s): Jonathan Singer
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering
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Intervertebral Disc Repair Using a 3D Porous Hybrid Protein Nanoscaffold
Histological analysis of rat intervertebral disc tissue prior to (left) and post injury (center) compared to 6 weeks post treatment (right).
Invention Summary:
Degeneration of fibrocartilaginous tissues, such as intervertebral discs (IVD), knee menisci, and other tendon-bone junctions, can lead to debilitating pain. IVD degeneration is the...
Published: 3/25/2025
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Inventor(s): Ki-Bum Lee, Letao Yang, Inbo Han
Keywords(s):
Category(s): Technology Classifications > Nanotechnology, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Biomaterials
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Cell-Based Biosensor for Monitoring Neuronal Stem Cell Differentiation
Movement of fluorescent cargo (EGFP, green) from the cytoplasm to the nucleus (Hoechst, blue) as early as 10 minutes after stimulation with hippocalcin
Invention Summary:
Monitoring neuronal differentiation in stem cells is vital to advance regenerative stem cell therapies and our understanding of various neurodegenerative diseases. Traditional...
Published: 2/21/2025
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Inventor(s): Ki-Bum Lee, Youngeun Kwon, Euiyeon Lee
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices
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Use Of Generative AI and Impedance Cytometry for Ionic Microscopy and Cell Imaging
Invention Summary:
Traditional cell identification methods, often relying on complex microscopy or fluorescence-activated cell sorting (FACS), are time-consuming, and require expensive and bulky instruments. This highlights the need for more precise, rapid, and affordable diagnostic tools.
Rutgers researchers have developed a novel...
Published: 3/25/2025
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Inventor(s): Mehdi Javanmard, Gulam Rather, Mahtab Kokabi
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices
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Novel N-Heterocyclic Carbene Ligands for Transition-Metal Catalysis
Invention Summary:
N-heterocyclic carbenes (NHCs) are tremendously valuable ligands in homogeneous catalysis. Some of the most popular ligands are NHCs that have demonstrated success in a number of organometallic transformations of great interest both in academia and industry. However, synthesizing NHCs poses challenges due to their air...
Published: 1/28/2025
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Physical Sciences & Engineering
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Wireless Readout & Label-Free Detection of Protein Biomarkers
The prototype has been built and tested using PBS spiked with HMGB1 protein. Voltage response by adding (A) NC to the well, and (B) protein sample to the well
Invention Summary:
The high demand for point-of-care (POC) biosensors is evident from their worldwide market projection of approximately $37 billion by 2026. The conventional use of...
Published: 1/22/2025
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Inventor(s):
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering
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Immobilizing enzymes by crosslinking biomolecular condensates
Proposed method for immobilizing enzymes by engineering enzyme-RGG fusion proteins, inducing phase separation into biomolecular condensates, and cross-linking condensates.
Invention Summary:
Enzyme immobilization techniques for industrial use often impede the effectiveness of the biocatalyst. A promising alternative method involves utilizing...
Published: 1/9/2025
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Inventor(s): Augene Park, Benjamin Schuster
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering
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Discriminating anti DDoS (DAD) Attacks
High level Architecture for Distributed anti Denial (DAD) of Service solution
Invention Summary:
With the increasing reliance on digital services, Distributed Denial of Service (DDoS) attacks have become one of the most challenging cybersecurity threats. These attacks aim to disrupt access to online resources by overwhelming servers with...
Published: 12/17/2024
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Inventor(s): Naftaly Minsky
Keywords(s): Cybersecurity, Networks
Category(s): Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Telecommunications & Networking
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