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A nerve injury-specific long noncoding RNA:
a new target for neuropathic pain
Relative level of nerve injury-specific RNAs in mice with sham surgery or chronic constriction injury (CCI) intrathecally administered PBS, missense oligonucleotides (MSO) or the herein designed antisense oligonucleotides (ASO) 7 days post-surgery.
Invention Summary:
7% to 10% of the general population endure neuropathic pain, which makes up...
Published: 4/21/2024
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Inventor(s): Yuanxiang Tao
Keywords(s): Neuropathic Pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
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Gsx1 GENE THERAPY TO TREAT SPINAL CORD INJURY
Gsx1 treatment promotes recovery of locomotion function in injured mice.
Invention Summary:
Spinal cord injury (SCI) can lead to permanent disruption of nervous system function. There is no effective treatment for promoting recovery of motor function after SCI currently available on the market. Previous research on SCI treatment focused on...
Published: 6/12/2023
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Inventor(s): Li Cai, Misaal Patel, Lisa Lyu
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy, Technology Classifications > CNS Disorder
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RNA-Aptamer-Mediated Base Editing System for Agriculture
Invention Summary:
The CRISPR/Cas system is a powerful tool for precision genetic engineering in organisms including plants. However, the conventional CRISPR technology depends on DSBs which may lead to undesired genetic events such as off-target insertions, deletions, and chromosomal translocations. The Base Editing technology...
Published: 4/21/2024
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Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
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Controlled Muscle-Specific Gene Delivery
Treatment with the AAV gene therapy with doxycycline (B) induced expression of the target gene.
Invention Summary:
Adeno-associated virus (AAV) vector-based gene therapy has the potential to treat a number of rare diseases. However, only two AAV-based gene therapies have been approved by the FDA, primarily due to toxicity and lack of specificity.
Researchers...
Published: 11/2/2022
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Inventor(s): Renping Zhou
Keywords(s): Gene editing
Category(s): Technology Classifications > Gene Therapy, Technology Classifications > Healthcare & Life Sciences
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RNA-Aptamer-Mediated Base Editing System
Invention Summary:
The CRISPR/Cas9 system is a powerful tool for targeted genetic engineering in
organisms ranging from animals to plants. Cas9 has intrinsic nuclease activity, which causes sequence specific DNA double-strand breaks (DSBs), leading to
activation of cellular pathways such as homology dependent repair (HDR) for gene conversion...
Published: 3/18/2024
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Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Research Tools, Technology Classifications > Gene Therapy
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MicroRNA-7 Gene Therapy Promotes Functional Recovery
Following Spinal Cord Injury
Following sever spinal cord compression, the AAV-miR-7 injected mice showed improved locomotor recovery, which is characterized by the Basso Mouse Scale (BMS).
Invention Summary:
Spinal cord injury (SCI) results in partial or complete loss of sensory or motor function. According to the National Spinal Cord Injury Statistical Center,...
Published: 4/21/2024
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Inventor(s): M. Maral Mouradian, Eunsung Junn, Myung-Sik Yoo
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
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A Chemogenetic Therapy for Neuropathic Pain
Invention Summary:
Neuropathic pain (NP) typically arises as a consequence of a lesion or disease affecting peripheral nerve fibers. Prominent features in the pathophysiology of neuropathic pain include increased, ectopic neuronal activity in pain pathways. In general, NP is frequently refractory to conventional analgesics and currently there are...
Published: 11/7/2022
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Inventor(s): Gary Aston-Jones
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
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dCas9 Protein Allele Sequestration for
Improved CRISPR Gene Editing
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Invention Summary:
CRISPR technology is widely used in research to edit genes in animals and cell lines and is moving towards therapeutic use in the clinic. Inherent to almost all methods employed in gene editing is the lack of control in target gene usage. A method to direct cleavage of only a single target within...
Published: 11/8/2022
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Inventor(s): Peter Romanienko, Ghassan Yehia
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Research Tools
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Novel Gene Therapy to Treat L-DOPA-Induced Dyskinesia
Viral vector injections of rAAV-∆FosB shRNA significantly reduced abnormal involuntary movements (AIMs) compared to control vector in a rat model of Parkinson’s disease.
Invention Summary:
Parkinson's disease (PD) is a progressive, debilitating, and currently incurable neurodegenerative disease. Long-term dopamine replacement therapy in...
Published: 2/21/2022
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Inventor(s): Mary Maral Mouradian, Stella Papa
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
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Personalized and Timed Release of Biomolecules
Invention Summary:
Protein/peptide-based therapeutics are powerful medications, however their use is often hampered by very short half-lives and the necessity for intravenous or subcutaneous injections.
Researchers from Rutgers University and Massachusetts General Hospital have developed a novel method to deliver protein/peptide-based therapeutics...
Published: 10/12/2022
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Inventor(s): Biju Parekkadan, Alexandra Burr, Alfred Tamayo
Keywords(s): Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Cell Therapy, Technology Classifications > Gene Therapy
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