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CD8 T Cell Senescence Gene Signatures that Predict Response to Chimeric Antigen Receptor T cell Therapy in Diffuse Large B Cell Lymphoma (ff)
Invention Summary:
CAR T-cell therapy has emerged as a promising treatment for patients with refractory B-cell malignancy. However, the response to CAR T-cell therapy can potentially be restricted due to age-related decline in immune function, known as immunosenescence. It is marked with the increase in senescence of CD8+ T cells. Predicting...
Published: 8/12/2025
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Inventor(s): Ricardo Martínez Zamudio, Utz Herbig
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences
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