Schematic of the active complex during the asymmetric hydrogenation of nitroalkenes using the developed chiral biphosphine metallorganocatalysts
To improve the inherent limitation of transition metal catalysts and organocatalysts, researchers have combined the two for synergistic effects. Despite the efforts, compatibility between catalysis, intermediates and solvents have been a limiting factor.
Research at Rutgers University have developed effective and versatile biphosphine metallorganocatalysts. The catalysts are highly efficient and compatible with several reaction conditions including the catalysis of asymmetric hydrogenation of nitroalkenes. They are composed of: a) a metal, which consists of a chiral ferrocenyl biphosphine moiety and enables high activity; and b) an organocatalyst, which preferably includes a thiourea moiety and provides selectivity. The combination results in >99% conversion and up to 99% enantioselectivity.
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- Easy to prepare
- Applicable to a variety of reactions
- High conversion rates
- Highly selective
- Efficient catalytic turnover
Intellectual Property & Development Status:
Issued patent US 9,744,528. Available for licensing and/or research collaboration.