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Invention Summary:
Dentin is a crucial part of our teeth, fortifying the enamel and providing protection from bacteria. Protecting the dentin layer itself from damage, such as that caused by acid and bacteria, is vital to dental hygiene. Without proper protection, tooth decay rates increase, and dentin can be slow to repair itself.
Dentin Booster™ is a groundbreaking product that strengthens and protects dentin, reducing acid and bacterial vulnerability (Fig. 1). Developed by Rutgers researcher, Dr. Saghiri and his team, the product uses ascorbic acid 2-phosphate (AA2P) combined with metal cations—magnesium (Mg), zinc (Zn), manganese (Mn), strontium (Sr), and barium (Ba)—to form a protective, acid-resistant layer that fortifies dentin. Through 3-day acid pH cycling, treated dentin demonstrated significant improvements in microhardness, compressive strength, and diametral tensile strength (DTS), with reduced solubility compared to untreated controls. In the study, all five AA2P-metal treatments enhanced mechanical properties and reduced solubility, with Sr- and Ba-based formulations showing the highest microhardness and compressive strength, supporting their potential to fortify caries-affected dentin and resist acid challenges (Fig. 2).
Market Applications:
Advantages:
Publications:
• Saghiri MA, Vakhnovetsky J, Abdolmaleki A, Samadi E, Samadi F, Napoli S, Conte M, Morgano SM. Mechanical properties of simulated dentin caries treated with metal cations and L-ascorbic acid 2-phosphate. Odontology. 2024 Apr;112(2):489-500. doi: 10.1007/s10266-023-00868-z. Epub 2023 Nov 17. PMID: 37978093. https://pubmed.ncbi.nlm.nih.gov/37978093
Intellectual Property & Development Status: Issued US patent 2025/0049680A1. Available for licensing and/or research collaboration. For any business development and other collaborative partnerships, contact: marketingbd@research.rutgers.edu
