Multipurpose UV sensitive monomer capable of conjugating complex macromolecules

                                                         Polymer-Alkyne Conjugates using UV sensitive monomer with linker


Invention Summary:

Biorthogonal “click” chemistry allows for the controlled introduction of multiple bioactive groups in a single molecule. Strain-promoted alkyne-azide cycloaddition (SPAAC) is an attractive click reaction in bioconjugate chemistry since it does not require the presence of toxic catalysts. A variety of compounds have been developed for efficient bioconjugation to azides; however, the intolerance of developed functional groups to radical polymerization reactions necessitates multi-step post-polymerization modifications and limits the number of polymer scaffolds that can be easily synthesized and tested. 

Rutgers researchers have synthesized a monomer that allows for controlled derivatization of a polymer with bioactive molecules. The developed UV-sensitive monomer is compatible with a wide range of monomer families and can be incorporated onto the polymer backbone via oxygen-tolerant PETRAFT polymerization and can be subsequently utilized for conjugating the polymer to other macromolecules via SPAAC click chemistry. 

Market Applications:

  • Site-directed drug delivery
  • Therapeutic treatments
  • Bioengineering

Advantages:

  • Monomer can be easily modified to change drug formulation.
  • Eliminates use of multiple reagents in post functionalization of polymers
  • Increases the efficiency of post functionalization. 

Intellectual Property & Development Status: 

Provisional patent application filed, patent pending. Available for licensing and/or search collaboration. For any business development and other collaborative partnerships contact marketingbd@research.rutgers.edu

 

Patent Information:
Contact:
Deborah Perez
Associate Director, Physical Sciences & Ag
Rutgers, The State University of New Jersey
848-932-4467
deborah.perez@rutgers.edu
Keywords:
Chemical and petrochemical industry
Polymers & Composites