​
Binding site of the target papain-like protease of the SARS-CoV-2 virus targeted by these inhibitors. Figure reproduced from inventors’ related paper in Science describing unrelated compounds (link).
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness have focused on developing oral antiviral medications that target highly conserved viral components, including polymerases and proteases essential for replication. For example, nirmatrelvir, an inhibitor of the SARS-CoV-2 main protease (Mpro) and a component of Pfizer’s Paxlovid drug product, exhibits broad-spectrum activity against coronaviruses. However, additional antivirals with new mechanisms of action are needed to combat viruses for which no antivirals are available or for which there is known danger of drug resistance.
Researchers at Rutgers have designed and tested a new series of inhibitors that target the papain-like protease (PLpro) of SARS-CoV-2 and demonstrate high potency. Supported by in vitro data demonstrating nanomolar IC50 values, they are among the most potent PLpro inhibitors to date.
Market Applications:
Advantages:
Intellectual Property & Development Status: Provisional application filed. Patent pending. Available for licensing and/or research collaboration. For any business development and other collaborative partnerships, contact: marketingbd@research.rutgers.edu
