Uses of Kombo Butter Extract and Derived Compounds as Novel Neuroprotective Agents

Invention Summary:

Rutgers scientists have developed novel methods to treat a variety of neurological disorders including ischemic stroke. The methods center on the use of novel neuroprotectants isolated from Kombo butter, an African nutmeg. The scientists additionally developed methods to produce and purify the Kombo butter, its extracts and derivatives. These compounds may find utility in the treatment of CNS.

Market Applications:

• CNS
• Stroke
• Parkinson’s
• Alzheimer’s
• Neuroprotection
• Kombo butter

Advantages:

Complementary and alternative medicine.

Intellectual Property & Development Status:

US 9,205,119

Select Publications:

• Botanicals for age-related diseases: from field to practice. Weaver CM, Barnes S, Wyss JM, Kim H, Morré DM, Morré DJ, Simon JE, Lila MA, Janle EM, Ferruzzi MG., Am J Clin Nutr. 2008 Feb;87(2):493S-7S.
• Chemical diversity of Lippia multiflora essential oils from West Africa.: Juliani, HR, Simon, JE, Quansah, C, Asare, E, Akromah, R, Acquaye, D, Asante-Dartey, J, Mensah, MLK, Fleischer, TC, Dickson, R, Found In: Journal of essential oil research : JEOR. 2008 Jan-Feb, v. 20, no. 1 p. 49-55.
• Cerebral microhemorrhages predict new disabling or fatal strokes in patients with acute ischemic stroke or transient ischemic attack. Boulanger JM, Coutts SB, Eliasziw M, Gagnon AJ, Simon JE, Subramaniam S, Sohn CH, Scott J, Demchuk AM; VISION Study Group.Stroke. 2006 Mar;37(3):911-4. Epub 2006 Feb 9.