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Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction
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Non-covalent direct inhibition of the Keap1-Nrf2 PPI resulting in upregulation of ARE-gene expression. Thus, increase ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions.
Invention Summary:
The Keap1-Nrf2-ARE system could protect...
Published: 1/14/2025
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Inventor(s): Longqin Hu, Ahmed Ali
Keywords(s):
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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