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Prodrugs and ADC Derivatives of Non-Camptothecin TOP1-Targeting Cancer Chemotherapeutics
Schematic Structure of an Antibody-Drug Conjugate (ADC) (en.wikipedia.org) Invention Summary: Topoisomerase 1 (Top1) is an essential enzyme in mammalian cells and is a validated target for the treatment of human cancers. Topotecan and irinotecan (camptothecin analogues) are two FDA approved Top1-targeted drugs. Despite being powerful anticancer drugs,...
Published: 3/13/2019   |   Inventor(s): Edmond LaVoie, Ajit Parhi
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics