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Novel Inhibitors of Keap1-Nrf2 Protein-Protein Interaction
Novel Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction
Invention Summary:
Nrf2 is a key transcription factor mediating anti-inflammatory and antioxidant responses in the body. Keap1 is a well-known repressor of Nrf2 that targets Nrf2 for its rapid proteasomal degradation. Dysfunctional Keap1-Nrf2 axis contributes to...
Published: 12/4/2024
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Inventor(s): Longqin Hu, Dhulfiqar Abed
Keywords(s): Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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