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Microneedle–Electroporation Platform for Nucleic Acids and Proteins

(a) Method implemented for intradermal delivery of DNA/RNA using coated microneedle array followed by electroporation, targeting the region between the epidermis and dermis. Blue spots around the microneedles indicated the spray coating dispersion after insertion. (b) Image of 4 x 4 microneedle array coated with 50 mg of plasmid DNA, 25 mg of trehalose,...

Published: 7/29/2026 | Inventor(s): Jeffrey Zahn, Hao Lin, Sunshine Littlecreek, Jerry Shan, David Shreiber, Miao Yu, Yasir Demiryurek

Keywords(s):

Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences

Negative Pressure-Assisted DNA Delivery

Fig.1. Dermal suction induces long-lasting antigen expression and T-cell response. (A) Dermal suction via a small hand-held device with a 6-mm orifice against the skin. Inset: immune response is 100 times stronger when compared with injection alone. (B) Post-suction skin demonstrates no damage nor erythema. (C) and (D): Benchmarking of suction against...

Published: 5/15/2026 | Inventor(s): Hao Lin, Jonathan Singer, David Shreiber, Jerry Shan, Jeffrey Zahn, Emran Lallow, Juliet Melnik, Nandita Jhumur

Keywords(s): Drug Delivery

Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Vaccine