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Identification of NFAT5 as a novel target for preventing KRAS targeted therapy resistance

Inhibiting NFAT5 attenuates pancreatitis-induced resistance to KRAS inhibition and extends mouse survival. Invention Summary: Resistance to KRAS targeted therapy in cancers involves epithelial-to-mesenchymal transition (EMT), which poses challenges for effective targeting. However, the mechanism underlying EMT associated KRAS resistance...

Published: 1/6/2025 | Inventor(s): Pingping Hou, Daiyong Deng

Keywords(s): Anti-cancer

Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics

Off-the-Shelf CAR-Macrophages for Solid Tumors

Invention Summary: Chimeric Antigen Receptor (CAR) therapy requires isolation of the respective immune cells from the patient’s blood, genetic manipulation, and infusion of the modified cells back into the patient’s body. This makes it personalized and effective but expensive. The CAR-T (modified T cells) therapy has shown...

Published: 1/11/2024 | Inventor(s): Pingping Hou

Keywords(s): Anti-cancer

Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences