At 40 and 80 min. following oral glucose challenge, the TPFA treated group had significantly lowered plasma glucose concentrations compared to the control group.
Invention Summary:
Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum (kinkeliba) and a procedure for the preparation of total piperidine flavan alkaloids (TPFA) that possess anti-diabetic properties.
Kinkeliba is a highly regarded medicinal plant in Africa, with roots, bark, fruit and leaves being used. In its native Sub-Saharan Africa, the fresh and brewed leaves of kinkeliba have a long established history as being safe multi-functional agents that are consumed regularly for a broad range of health, prophylactic, curative, and anti-disease benefits. Kinkeliba herbal teas are a readily available niche specialty consumer product.
Our scientists have identified and isolated specific compounds from kinkeliba leaves that result in a significant glucose-lowering functionality and can be administered in efficacious dosages as a dietary supplement or food additive. Animal studies have shown that the isolated compounds:
- decrease fasting plasma glucose levels
- increase glucose tolerance
- lower plasma insulin levels, and
- decrease liver expression of the PEPCK gene, which indicates antidiabetic activity
Further experiments have demonstrated an anti-inflammatory action of the compounds. An effective preparation method has also been developed.
Market Applications:
- Diabetes, metabolic disorders, weight loss, diuretics
- Can be blended into existing formulations (food, beverage, or nutraceutical) to boost efficacy and broaden application and efficacy profile
Advantages:
- Kinkeliba tea has a well documented traditional and safe medicinal use
- Established safety profile
- Readily available source
- Rich in potent antioxidants
- Distinct attributes and functionality as compared to other common tea (e.g., green tea or black tea) derivatives
Intellectual Property & Development Status:
US 8,642,769
