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miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning.
Invention Summary:
Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 11/12/2024
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Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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Innovative Assessment of Cardiovascular Function for Individualized Treatment, Training and Diet Plans
Invention Summary:
Measures to assess cardiovascular health range from simple tests such as blood pressure, resting heart rate, or stress test to ones that are highly invasive such as pulmonary catheterization. In patients at risk for peripheral artery disease, such as diabetics, there are other measures including reactive hyperemia tests...
Published: 12/4/2024
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Inventor(s): Andrew Gow
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Ag Biotech
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Biodegradable and Biocompatible Salicylic Acid Releasing
Polymer to Enhance Diabetic Bone Regeneration
pCT images of control and polyaspirin treated defects after 4 weeks. Graph shows average percent bone fill in defects after 4 weeks
Invention Summary:
Nearly 300 million people suffer from diabetes mellitus worldwide, with 25 million diabetics in the U.S. alone. Patients with diabetes are more prone to fractures, periodontitis,...
Published: 11/1/2024
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Inventor(s): Kathryn Uhrich, Roselin Rosario-Melendez, Michelle Morano, Sabrina Snyder, Joseph Fiorellini (UPENN), Dana Graves (UPENN), Keisuke Wada (UPENN)
Keywords(s): Biomaterials, Diabetes & Metabolic Disorders, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel Process for Early Diagnosis and Treatment of Diabetic
Invention Summary:
Sixty to seventy percent of diabetes patients suffer from the nerve disorder diabetic peripheralneuropathy (DPN), which causes pain, tingling, numbness in extremities and can lead to devastating (complications such as falls, amputations, muscle weakness, unsteady gait and foot ulcers. Current diagnostic methods for neuropathy...
Published: 4/21/2024
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Inventor(s): Nizar Souayah
Keywords(s): Bioinformatics, Diabetes & Metabolic Disorders
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Modified Kisspeptin Receptor Agonist as Novel Treatment of Non-Fatty Liver Disorder and Non-Alcoholic Steatohepatitis
TAK-448 protected insulin resistant, obese mice against the development of hepatic steatosis:
H& E showing fatty liver.
Invention Summary:
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder worldwide that can progress to steatohepatitis (NASH), the leading reason for liver transplants. In the U.S., there are...
Published: 10/14/2024
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Inventor(s): M. Moshmi Bhattacharya Babwah, Andy Babwah, Sally Radovick, Fredric Wondisford
Keywords(s): Diabetes & Metabolic Disorders, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Anti-Diabetic Agents from Leaves of Combretum micranthum (Kinkeliba)
At 40 and 80 min. following oral glucose challenge, the TPFA treated group had significantly lowered plasma glucose concentrations compared to the control group.
Invention Summary:
Rutgers scientists have developed a proprietary method of extracting and purifying a novel type of piperidine flavan alkaloids from the leaves of Combretum micranthum...
Published: 12/4/2024
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Inventor(s): James Simon
Keywords(s): Diabetes & Metabolic Disorders
Category(s): Technology Classifications > Agriculture, Technology Classifications > Food, Nutrition and Nutraceuticals, Technology Classifications > Healthcare & Life Sciences
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