Iodinated Salicylate-Polymers | Rutgers University Innovation Ventures

Iodinated Salicylate-Polymers

 

FIG. 2( a) is a cross-sectional view of an apparatus or article including a medical device and an iodinated polymer coating in accordance with some embodiments. FIG. 2( b) is a perspective view of the medical device, shown in FIG. 2( a), having a surface that is partially coated with the iodinated polymer coating in accordance with some embodiments.


Invention Summary:

A drug delivery system comprises of therapeutic agent incorporated into the polymer backbone. Such polymers are also used to coat medical apparatus or devices such as stents, that upon application degrade and thereby deliver the therapeutic agent. However, polymeric devices are not visible using X-Ray imaging techniques. Thus, it becomes difficult to monitor the placement of the polymeric devices during or after implantation. This limits the practical uses of polymeric devices made from synthetic or biodegradable polymeric materials. There is a need for materials that can be used to prepare or coat polymeric devices that are visible using X-Ray imaging techniques.

Rutgers researchers have developed iodinated polymers that can be used to form or coat devices that are visible using X-Ray imaging techniques. These are biodegradable, iodinated polymer comprises of a polyanhydride, polyester, polycarbonate or polyamide, having a backbone comprising one or more iodinated aryl rings. More specifically, X-ray opaque iodinated salicylic acid-based poly(anhydride-esters) were synthesized using two different methods, melt-condensation and solution polymerization. The process generates iodinated polymers with required radiopacity needed for high X-ray visibility and also exhibit biocompatibility at low concentrations. 

Advantages:

  • Novel, biodegradable iodinated polymer coating with multiple applications
  • High radiopacity needed for X-ray visibility
  • Use in medical device delivery systems due to compatibility with heat sensitive drugs, solution

Market Applications:

  • This biodegradable iodinated polymer coating also has applications in food, cosmetic, pharmaceutical, chemical industry and others.
  • The polymer coating may be incorporated onto implantable medical devices comprised of metals, ceramics and polymer devices such as stent, orthopedic device, bone plate, pacemaker, surgical mesh etc.

Intellectual Property & Development Status: Patent Granted US8361453B2. Available for licensing and/or research collaboration.     

Patent Information: