|
Multi-Faceted Anti-inflammatory Neuroprotective Nanoparticles for Treating Alzheimer’s Disease
Invention Summary:
Alzheimer's disease (AD) is characterized by progressive neurodegeneration and a high mortality rate in the elderly. Current therapeutic strategies fall short in halting the underlying cognitive decline and nerve cell damage. The primary features of AD are the accumulation of extracellular amyloid plaques, uncontrolled...
Published: 7/9/2025
|
Inventor(s): Hoda Gebril, Prabhas Moghe, Kathryn Uhrich
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
|
|
Amphiphilic macromolecules with novel hydrophobic segments
Invention Summary:
Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads...
Published: 8/12/2025
|
Inventor(s): Kathryn Uhrich, Allison Faig, Dalia Abdelhamid, Li Gu
Keywords(s): Antibacterial, Biomaterials, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
|
|
Amphiphilic Polymer Stabilized Nanoparticles with Enhanced Biological Stability and Activity
Experimental oxLDL macrophage cellular uptake results after 24-hr incubation with AM micelle or NP configurations under serum free conditions (white bars), 5% FBS (gray bars) and 20% FBS (black bars).
Invention Summary:
According to Centers for Disease Control and Prevention nearly 25% of deaths in the US is due to cardiovascular...
Published: 8/12/2025
|
Inventor(s): Kathryn Uhrich, Prabhas Moghe, Adam York, Robert Prud'homme
Keywords(s): Biomaterials, Cardiovascular, Drug Delivery, Nanoparticles, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
|
|
Thermo-Activated Lubricant Additives for Improving Engine Efficiency and Fuel Economy
Controlled Release Friction Reduction over Time
Invention Summary:
Friction modifiers (FMs) have been extensively studied as lubricant additives that could improve lubricity of base oil friction profiles to enhance fuel economy by the petrochemical and automobile industries. There are two classes of FMs, the ash FM (organo-molybdenum molecules) and...
Published: 8/12/2025
|
Inventor(s): Kathryn Uhrich, Jonathan Faig, Yingyue Zhang, Shuji LUO, Man KIT NG, Alan SCHILOWITZ, Anne SHOUGH
Keywords(s): Biomaterials, Chemical and petrochemical industry
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials
|
|
Versatile Biodegradable, Bioactive-Based Polymers for Topical, Cosmetic and Personal Care Applications
A. Structure of salicylic acid-based polymer and its degradation products.
B. Polymer degradation rates with different linker molecules.
C. Free ferulic acid in aqueous solution is unstable and turns brown after 10 days (left). Ferulic acid-based polymers are stable and aesthetically more pleasing in solution under the same condition (right).
Invention...
Published: 8/12/2025
|
Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences
|
