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Multi-Faceted Anti-inflammatory Neuroprotective Nanoparticles for Treating Alzheimer’s Disease
Invention Summary:
Alzheimer's disease (AD) is characterized by progressive neurodegeneration and a high mortality rate in the elderly. Current therapeutic strategies fall short in halting the underlying cognitive decline and nerve cell damage. The primary features of AD are the accumulation of extracellular amyloid plaques, uncontrolled...
Published: 4/17/2024
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Inventor(s): Hoda Gebril, Prabhas Moghe, Kathryn Uhrich
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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Biodegradable and Biocompatible Bioactive-based Polymers - Versatile Platform Technology
Invention Summary:
The Uhrich group has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), antioxidants (e.g., ferulic acid) and antimicrobials (e.g., carvacrol). Bioactive molecules are incorporated into polymer backbones through labile linkages,...
Published: 4/17/2024
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Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Bioengineering scaffolds, Biomaterials, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Biodegradable and Biocompatible Polymers for Controlled NSAID Delivery
A. Drug delivery system hydrolysis – composed of 1 (Ibuprofen), 2 (naproxen) and 3 (tartatic acid) into polymer backbones. B. Hydrolytic degradation of the ibuprofen-based polyester.
Invention Summary:
Ibuprofen and naproxen are commonly used to treat pain and swelling associated with rheumatoid arthritis and osteoarthritis....
Published: 4/17/2024
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Inventor(s): Kathryn Uhrich, Roselin Rosario-Melendez
Keywords(s): Biomaterials, Inflammation, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Iodinated Salicylate-Polymers
FIG. 2( a) is a cross-sectional view of an apparatus or article including a medical device and an iodinated polymer coating in accordance with some embodiments. FIG. 2( b) is a perspective view of the medical device, shown in FIG. 2( a), having a surface that is partially coated with the iodinated polymer coating in accordance...
Published: 4/17/2024
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Inventor(s): Kathryn Uhrich, Ashley Carbone
Keywords(s): Anti-cancer, Drug Delivery, Imaging, Implants, Polymers & Composites, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Polymers/Composites/Materials
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Antioxidant-based poly(anhydride-esters)
Invention Summary:
Free radicals have been identified as major sources of oxidative stress in cells leading to DNA damage. This increased oxidative stress has been implicated in various deleterious conditions including cardiovascular diseases, neurodegenerative diseases, and cancer, while also contributing to the physiology of...
Published: 4/17/2024
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Inventor(s): Kathryn Uhrich, Michelle Morano
Keywords(s): Biomaterials, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences
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Amphiphilic macromolecules with novel hydrophobic segments
Invention Summary:
Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads...
Published: 4/17/2024
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Inventor(s): Kathryn Uhrich, Allison Faig, Dalia Abdelhamid, Li Gu
Keywords(s): Antibacterial, Biomaterials, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Amphiphilic Polymer Stabilized Nanoparticles with Enhanced Biological Stability and Activity
Experimental oxLDL macrophage cellular uptake results after 24-hr incubation with AM micelle or NP configurations under serum free conditions (white bars), 5% FBS (gray bars) and 20% FBS (black bars).
Invention Summary:
According to Centers for Disease Control and Prevention nearly 25% of deaths in the US is due to cardiovascular...
Published: 4/17/2024
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Inventor(s): Kathryn Uhrich, Prabhas Moghe, Adam York, Robert Prud'homme
Keywords(s): Biomaterials, Cardiovascular, Drug Delivery, Nanoparticles, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Biodegradable and Biocompatible Salicylic Acid Releasing
Polymer to Enhance Diabetic Bone Regeneration
pCT images of control and polyaspirin treated defects after 4 weeks. Graph shows average percent bone fill in defects after 4 weeks
Invention Summary:
Nearly 300 million people suffer from diabetes mellitus worldwide, with 25 million diabetics in the U.S. alone. Patients with diabetes are more prone to fractures, periodontitis,...
Published: 4/17/2024
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Inventor(s): Kathryn Uhrich, Roselin Rosario-Melendez, Michelle Morano, Sabrina Snyder, Joseph Fiorellini (UPENN), Dana Graves (UPENN), Keisuke Wada (UPENN)
Keywords(s): Biomaterials, Diabetes & Metabolic Disorders, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel Cationic Amphiphiles Control Biofilm Formation for Bacterial Vaginosis
Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV. Cationic Amphiphile Concentration (μM)
Invention Summary:
Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. BV can lead to serious complications such as abortion,...
Published: 4/17/2024
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Inventor(s): Kathryn Uhrich, Allison Faig
Keywords(s): Antibacterial, Biofilm, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Biodegradable and Versatile Copolymers to Promote Wound Healing
Invention Summary:
Wound healing is a complex and dynamic process of replacing devitalized and missing cellular structures and tissue layers and thus there is a need for a biodegradable and versatile copolymers to promote wound healing.
Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise...
Published: 4/17/2024
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Inventor(s): Kathryn Uhrich, Sabrina Snyder
Keywords(s): Biomaterials, Drug Delivery, Neurological disorder & neuropathic pain, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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