JSF-3285, A Novel KasA Inhibitor for Tuberculosis
Figure 1. Summary profile of JSF-3285: A) In vitro profile. B) X-ray crystal structure and
binding constant for complex with KasA. C) In vivo profile in mouse chronic infection model.
New antibacterial drugs that treat multidrug resistant mycobacterium tuberculosis (MDR TB) represent an area of high medical need. The current tuberculosis...
Inventor(s): Joel Freundlich, David Alland, Matthew Neiditch, Glenn Capodagli, Sean Ekins, Pradeep Kumar, Divya Awasthi, Daigo Inoyama
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics