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Treatments for tuberculosis and non-tuberculous mycobacterial infections: dual-targeted rifamycin-AAP conjugates (RifaAAPs)
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Invention Summary:
RifaAAPs are novel dual-targeted, low-resistance-emergence, orally-available compounds for treatment of tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections--including drug-resistant, multi-drug-resistant (MDR), and extensively-drug-resistant (XDR) strains.
Researchers indicate that...
Published: 1/31/2025
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Inventor(s): Richard Ebright, Yon Ebright, Chih-Tsung Lin
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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ANTIBACTERIAL AGENTS: DUAL-TARGETED RNA POLYMERASE INHIBITORS (BENZOXAZINO-RIFAAAPS
Invention Summary:
RifaAAPs are novel dual-targeted, low-resistance-emergence, orally-available compounds for treatment of tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections--including drug-resistant, multi-drug-resistant (MDR), and extensively-drug-resistant (XDR) strains.
Researchers indicate that RifaAAPs comprise...
Published: 1/31/2025
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Inventor(s): Richard Ebright, Yon Ebright, Chih-Tsung Lin
Keywords(s): Antibacterial
Category(s): Technology Classifications > Infectious Disease, Technology Classifications > Healthcare & Life Sciences
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ANTIBACTERIAL AGENTS: CO-SOLVENT-FREE, SURFACTANT-FREE FORMULATIONS OF PYRONINS
Invention Summary:
APYs are novel, orally available compounds for treatment of infections caused by Gram-positive bacterial pathogens, fastidious Gram-negative bacterial pathogens, and some non-fastidious Gram-negative bacterial pathogens--including drug-resistant and multi-drug-resistant (MDR) strains.
Our researchers have indicated...
Published: 1/31/2025
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Inventor(s): Richard Ebright, Yon Ebright
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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ANTIBACTERIAL AGENTS: O-ALKYL-DEUTERATED PYRONINS (PYS) AND ARYL PYRONINS (APYS)
Invention Summary:
APYs are novel, orally available compounds for treatment of infections caused by Gram-positive bacterial pathogens, fastidious Gram-negative bacterial pathogens, and some non-fastidious Gram-negative bacterial pathogens--including drug-resistant and multi-drug-resistant (MDR) strains.
Our researchers have indicated...
Published: 1/31/2025
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Inventor(s): Richard Ebright, Yon Ebright
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Treatments for drug-susceptible and drug-resistant bacterial infections: arylmyxopyronins (APYs)
Invention Summary:
APYs are novel, orally available compounds for treatment of infections caused by Gram-positive bacterial pathogens, fastidious Gram-negative bacterial pathogens, and some non-fastidious Gram-negative bacterial pathogens--including drug-resistant and multi-drug-resistant (MDR) strains.
Our researchers have indicated...
Published: 1/31/2025
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Inventor(s): Richard Ebright, Yon Ebright
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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Enterovirus D68 capsid inhibitors as antivirals
Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947.
Invention Summary:
Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals...
Published: 1/27/2025
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Inventor(s): Jun Wang, Yanmei Hu, Kan Li
Keywords(s): Antibacterial, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Application of a PS-Targeting Molecule Combined with Memory T cell Antigen for Therapeutic, Diagnostic, and Adjuvant Use
PS binding molecules could restore inactive or memory T cell functions.
Invention Summary:
Phosphatidylserine (PS) exposure on the cell surface is often a signal for phagocytosis and can lead to an immunosuppressive effect. Therefore, its inhibition by PS-binding biomolecules can promote a more immuno-responsive microenvironment. However,...
Published: 1/21/2025
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Inventor(s): Alok Choudhary
Keywords(s): Antibacterial, Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Infectious Disease, Technology Classifications > Healthcare & Life Sciences
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Biodegradable and Biocompatible Bioactive-based Polymers - Versatile Platform Technology
Invention Summary:
The Uhrich group has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), antioxidants (e.g., ferulic acid) and antimicrobials (e.g., carvacrol). Bioactive molecules are incorporated into polymer backbones through labile linkages,...
Published: 11/1/2024
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Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Bioengineering scaffolds, Biomaterials, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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New Antimalarials Based on the TBN Scaffold
Invention Summary:
Malaria infects over 200 million people and results in nearly half a million deaths as well as up to $12 billion USD in lost economic activity. Although the prevalence of malaria has decreased steadily over the last two decades, progress has stagnated in recent years due to the emergence of drug-resistant malarial strains. These...
Published: 7/16/2024
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Inventor(s): Spencer Knapp, Robert Barrows, Rodney Kiplin Guy, Jared Hammill, Christopher Davis
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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Amphiphilic macromolecules with novel hydrophobic segments
Invention Summary:
Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads...
Published: 12/4/2024
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Inventor(s): Kathryn Uhrich, Allison Faig, Dalia Abdelhamid, Li Gu
Keywords(s): Antibacterial, Biomaterials, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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