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Biodegradable and Biocompatible Bioactive-based Polymers - Versatile Platform Technology
Invention Summary:
The Uhrich group has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), antioxidants (e.g., ferulic acid) and antimicrobials (e.g., carvacrol). Bioactive molecules are incorporated into polymer backbones through labile linkages,...
Published: 11/1/2024
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Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Bioengineering scaffolds, Biomaterials, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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New Antimalarials Based on the TBN Scaffold
Invention Summary:
Malaria infects over 200 million people and results in nearly half a million deaths as well as up to $12 billion USD in lost economic activity. Although the prevalence of malaria has decreased steadily over the last two decades, progress has stagnated in recent years due to the emergence of drug-resistant malarial strains. These...
Published: 7/16/2024
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Inventor(s): Spencer Knapp, Robert Barrows, Rodney Kiplin Guy, Jared Hammill, Christopher Davis
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease
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Amphiphilic macromolecules with novel hydrophobic segments
Invention Summary:
Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads...
Published: 12/4/2024
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Inventor(s): Kathryn Uhrich, Allison Faig, Dalia Abdelhamid, Li Gu
Keywords(s): Antibacterial, Biomaterials, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel Cationic Amphiphiles Control Biofilm Formation for Bacterial Vaginosis
Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV. Cationic Amphiphile Concentration (μM)
Invention Summary:
Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. BV can lead to serious complications such as abortion,...
Published: 11/1/2024
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Inventor(s): Kathryn Uhrich, Allison Faig
Keywords(s): Antibacterial, Biofilm, Biomaterials, Drug Delivery, Personal Care, Cosmeceuticals, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Cationic Amphiphile for Antimicrobial Applications
The structure of CAms 5a, 5b, 5c, 8a, 8b, and 8c
Invention Summary:
The development of antibiotic-resistant bacteria is a prevalent concern that has prompted the development of new antimicrobial agents. Naturally-occurring antimicrobial peptides (AMPs) offer advantages over conventional antibiotics due to a reduced development of resistance mechanisms...
Published: 11/1/2024
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Inventor(s): Kathryn Uhrich, Yingyue Zhang, Allison Faig, Michael (mikhail) Chikindas
Keywords(s): Antibacterial, Biomaterials, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Film Forming Foam (FFF) for Burn Wounds/Burnflex
Invention Summary:
Many available dressings on the market use latex, PVC, or polyurethane as barrier-like components to protect the patient from outside elements. The current use of these components presents a problem of waste and contamination. Other available options in the market are hydrogel-based dressings that may be coated in silver sulfadiazine,...
Published: 9/12/2024
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Inventor(s): Maricely Ramírez-Hernández, Tewodros Asefa, Jeffrey Boyd, Javiera Norambuena-Morales
Keywords(s): Antibacterial, Drug Delivery, Nanoparticles, Nanotechnology, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Consumer & Household Goods
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Pyrrole-based Inhibitors of PfPKG for the Treatment of Malaria
Invention Summary:
The emergence and spread of artemisinin-resistant plasmodium falciparum in Southeast Asia is a compelling reminder to develop new drugs for malaria prophylaxis and treatment. Drugs that target pre-erythrocytic stages are an essential component of the anti-malarial effort because a decrease in liver infection by sporozoites significantly...
Published: 10/21/2024
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Inventor(s): David Augeri, Purnima Bhanot, Raheel Fondekar, John Gilleran
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences
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Low-Cost, Flexible, Paper-Based Plasma Sanitizer
Low-Cost, Flexible, Paper-Based Plasma Sanitizer
Invention Summary:
Healthcare-associated infections (HAIs) are a major challenge facing disease control organizations and healthcare providers worldwide. In 2011, there were 721,800 cases of HAIs reported in the US, with 75,000 patients ultimately dying from the infections. Because a leading cause...
Published: 6/13/2024
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Inventor(s): Aaron Mazzeo, Jingjin Xie, Qiang CHEN, Subrata Roy
Keywords(s): Antibacterial, Antiviral, Cleaning/Disinfecting Products, Electronics, Flexible electronics, Packaging, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Electronics/Semiconductor, Technology Classifications > Therapeutics
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JSF-3285, A Novel KasA Inhibitor for Tuberculosis
Figure 1. Summary profile of JSF-3285: A) In vitro profile. B) X-ray crystal structure and
binding constant for complex with KasA. C) In vivo profile in mouse chronic infection model.
Invention Summary:
New antibacterial drugs that treat multidrug resistant mycobacterium tuberculosis (MDR TB) represent an area of high medical need. The current tuberculosis...
Published: 7/26/2024
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Inventor(s): Joel Freundlich, David Alland, Matthew Neiditch, Glenn Capodagli, Sean Ekins, Pradeep Kumar, Divya Awasthi, Daigo Inoyama
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel Nanomaterial for Prolonged and Sustained Antibacterial Efficacy
a) BAC release profile at pH 4.0, 5.0, 6.5, and 7.4. b) The percentage of S. aureus survival upon exposure to BAC loaded nanoparticles after 0, 3, and 6 hours.
Invention Summary:
Quaternary ammonium cationic (QAC) surfactants are one of the preferred choices for antibacterial applications. The compounds are water and oil soluble, and they cover...
Published: 10/21/2024
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Inventor(s): Tewodros Asefa, Viktor Dubovoy, Anjani Ganti, Jeffrey Boyd
Keywords(s): Antibacterial, Nanoparticles, Nanotechnology, Personal Care, Cosmeceuticals
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology, Technology Classifications > Healthcare & Life Sciences
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