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TGFβ-treatment of organoid cultures primes for regenerative therapy of damaged epithelia
A) GI epithelial organoids treated with TGFβ (right panel) acquire a spherical morphology and regenerative identity compared to vehicle-treated organoids (left panel). B-D) Organoids treated with TGFβ engraft more efficiently into the colon of mice exhibiting ulcerative colitis-like disease based on fluorescent micrographs (B), size per colonized...
Published: 10/21/2024
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Inventor(s): Michael Verzi, Lei Chen
Keywords(s): Gastrointestinal disease
Category(s): Technology Classifications > Healthcare & Life Sciences
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