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IFN-Lambda1 Polypeptides as Antiviral and Anticancer Therapeutics
Only IFN-λ and not IFN-α protects mice from lethal high-virulence influenza A virus infection
Invention Summary:
Interferons (IFNs) are well known for their potent broad-spectrum antiviral activities. In addition, these pluripotent cytokines can also regulate cell growth and differentiation, tissue homeostasis and angiogenesis, and...
Published: 7/16/2024
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Inventor(s): Sergei Kotenko, Grant Gallagher
Keywords(s): Antiviral
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel Fusion Polypeptides as Antiviral and Cancer Therapeutics
Antitumor and antiviral effects of the fusion IFN-β-IFN-λ in vivo
Invention Summary:
Type I and Type III interferons (IFNs) are well known for their potent broad-spectrum antiviral activities. In addition, these pluripotent cytokines can also regulate cell growth and differentiation, tissue homeostasis, angiogenesis, as well as immune...
Published: 10/22/2024
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Inventor(s): Sergei Kotenko, Joan Durbin
Keywords(s): Anti-cancer, Antiviral
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19
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Novel Phosphatidylserine-Targeting Immunobiologicals for Cancer and Viral Treatment
PS-targeting biological inhibits tumor growth and virus infection
Invention Summary:
Phosphatidylserine (PS) is a phospholipid that is restricted to the inner plasma membrane in healthy cells but is externalized in apoptotic or stressed cells abundantly present in tumor microenvironment or in sites of virus infection. PS is also present on the...
Published: 7/16/2024
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Inventor(s): Sergei Kotenko, Viralkumar Davra, Raymond Birge
Keywords(s): Anti-cancer, Antiviral
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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