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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below.
Invention Summary:
The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025
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Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes.
Invention Summary:
The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
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Inventor(s): Jun Wang, Prakash Jadhav, Bin Tan, Haozhou Tan
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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Small molecules that target RNA structures within the CoV genome
Chemical structure of the three lead molecules derived from the focused library screen against OC43-infected Vero E6 cell screening (Zafferani et al 2021)
Invention Summary:
The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes...
Published: 8/12/2025
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Inventor(s): Amanda Hargrove, Blanton Tolbert, Gary Brewer, Neeraj Patwardhan, Mei-Ling Li
Keywords(s): Antiviral, Respiratory Disease
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Plant-based system for generation of single-domain antibodies to combat viral infections
Plant-derived antibodies designed to target SARS- CoV-2 bind to SARS-CoV2 spike protein similar to bacteria derived antibodies based on ELISA.
Invention Summary:
The use of neutralizing antibodies is a strategy for treating viral infections, especially for individuals who are immunocompromised or have high-risk medical conditions. Mass production...
Published: 8/12/2025
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Inventor(s): Tamara Minko, Natalia Pogrebnyak, Andrew Shen, Obeid Malekshah
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Vaccine
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SARS-COV-2 papain-like protease inhibitors as antivirals
Novel compounds and their use as an inhibitor for SARS-CoV-2.
Invention Summary:
Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....
Published: 7/9/2025
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Inventor(s): Jun Wang, Edward Arnold, Francesc Ruiz Figueras, Prakash Jadhav, Bin Tan, Ahmadullah Ansari, Ashima Chopra
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
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“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
S309-CAR cells show higher lysis of cells transfected with RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 8/12/2025
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Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > COVID-19
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“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
CR3022-CAR cells have greater lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms are admitted into the ER have grim prognosis and have expensive limited treatment options. A large...
Published: 8/12/2025
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Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
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Sigma-1 Receptor Antagonists – Non-Addictive Pain Management
Invention Summary:
The sigma 1 receptor (S1R), a molecular chaperone protein located in the endoplasmic reticulum and plasma membranes, plays important roles in various pathological disorders including pain. The potential commercial applications of novel S1R antagonists are twofold: 1) as stand-alone therapy for the treatment of chronic neuropathic...
Published: 8/12/2025
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Inventor(s): William Welsh, Youyi Peng
Keywords(s): Antiviral, Neurological disorder & neuropathic pain, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Low-Cost, Flexible, Paper-Based Plasma Sanitizer
Low-Cost, Flexible, Paper-Based Plasma Sanitizer
Invention Summary:
Healthcare-associated infections (HAIs) are a major challenge facing disease control organizations and healthcare providers worldwide. In 2011, there were 721,800 cases of HAIs reported in the US, with 75,000 patients ultimately dying from the infections. Because a leading cause...
Published: 8/12/2025
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Inventor(s): Aaron Mazzeo, Jingjin Xie, Qiang CHEN, Subrata Roy
Keywords(s): Antibacterial, Antiviral, Cleaning/Disinfecting Products, Electronics, Flexible electronics, Packaging, Wound healing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Electronics/Semiconductor, Technology Classifications > Therapeutics
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Novel Monodisperse PEGtide Dendrons as Nanocarrier for Drug Delivery
Representative Structure of PEGtide
Invention Summary:
Dentrimers and dendrons have generated tremendous interest as nanocarriers for various drug delivery applications. Rutgers scientists have developed a series of novel monodisperse PEGtide dendrons with versatility to accommodate various drug delivery demands.
PEGtide dendrons containing...
Published: 8/12/2025
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Inventor(s): Patrick Sinko, Jieming Gao
Keywords(s): Antibacterial, Anti-cancer, Antiviral, Biomaterials
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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