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Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers
A) Novel mechanism of action: a short exposure to ZMCs increases zinc levels in tumors enough to restore normal structure/function to mutant p53 which leads to p53 mediated cancer cell death. B) Novel formulation: Synthesizing ZMCs as a zinc-loaded complex (Zn-1) improves survival in a pancreatic cancer mouse model compared to the ZMC compound alone....
Published: 1/26/2021   |   Inventor(s): Spencer Kimball, Darren Carpizo, John Gilleran
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers
A) Novel mechanism of action: a short exposure to ZMCs increases zinc levels in tumors enough to restore normal structure/function to mutant p53 which leads to p53 mediated cancer cell death. B) Novel formulation: Synthesizing ZMCs as a zinc-loaded complex (Zn-1) improves survival in a pancreatic cancer mouse model compared to the ZMC compound alone....
Published: 1/26/2021   |   Inventor(s): Spencer Kimball, Darren Carpizo, John Gilleran
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers
A) Novel mechanism of action: a short exposure to ZMCs increases zinc levels in tumors enough to restore normal structure/function to mutant p53 which leads to p53 mediated cancer cell death. B) Novel formulation: Synthesizing ZMCs as a zinc-loaded complex (Zn-1) improves survival in a pancreatic cancer mouse model compared to the ZMC compound alone....
Published: 1/26/2021   |   Inventor(s): Darren Carpizo, David Augeri, Spencer Kimball, Xin Yu
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics