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Search Results - john+gilleran

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Pyrrole-based Inhibitors of PfPKG for the Treatment of Malaria
Invention Summary: The emergence and spread of artemisinin-resistant plasmodium falciparum in Southeast Asia is a compelling reminder to develop new drugs for malaria prophylaxis and treatment. Drugs that target pre-erythrocytic stages are an essential component of the anti-malarial effort because a decrease in liver infection by sporozoites significantly...
Published: 6/4/2021   |   Inventor(s): David Augeri, Purnima Bhanot, Raheel Fondekar, John Gilleran
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences
Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers
A) Novel mechanism of action: a short exposure to ZMCs increases zinc levels in tumors enough to restore normal structure/function to mutant p53 which leads to p53 mediated cancer cell death. B) Novel formulation: Synthesizing ZMCs as a zinc-loaded complex (Zn-1) improves survival in a pancreatic cancer mouse model compared to the ZMC compound alone....
Published: 1/26/2021   |   Inventor(s): Spencer Kimball, Darren Carpizo, John Gilleran
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers
A) Novel mechanism of action: a short exposure to ZMCs increases zinc levels in tumors enough to restore normal structure/function to mutant p53 which leads to p53 mediated cancer cell death. B) Novel formulation: Synthesizing ZMCs as a zinc-loaded complex (Zn-1) improves survival in a pancreatic cancer mouse model compared to the ZMC compound alone....
Published: 1/26/2021   |   Inventor(s): Spencer Kimball, Darren Carpizo, John Gilleran
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics