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A Humanized Yeast System for mTOR Kinase Inhibitor Screening and Studies

Invention Summary: mTOR kinase is a highly conserved central regulator of cell growth and metabolism, and a key cancer drug target. Numerous mTOR kinase inhibitors have been developed but have not been approved by FDA. A new screening tool for mTOR kinase inhibitors will facilitate mTOR therapeutic development and related pharmacology studies. Rutgers...

Published: 2/20/2026 | Inventor(s): Steven Zheng

Keywords(s): Drug Discovery/Screening

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics

A Novel Diagnostic Assay for Predicting Patients’ Resistance to mTOR Kinase Inhibitors

Invention Summary: Mechanistic Target of Rapamycin (mTOR) is a highly conserved serine/thereonine protein kinase that plays a crucial role as part of two distinct kinase complexes, mTOR1C and mTOR2C, to regulate cell growth and metabolism. Abnormal activation of mTOR has been implicated in the pathogenesis of several cancers, type 2 diabetes, obesity,...

Published: 2/20/2026 | Inventor(s): Steven Zheng

Keywords(s): Proteins

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics