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DEVELOPMENT OF SPECIFIC CRK-LIKE ADAPTOR PROTEIN INHIBITORS FOR CANCER THERAPY
NC5 inhibits tumor growth and prolongs survival in vivo. NC5 treatment inhibits TNBC tumor growth and prolongs mice survival in xenograft and PDX mouse models. (A) Survival of mice bearing MDA-MB-231-Luc orthotopic xenograft tumors following treatment with vehicle (black line), Gleevec (blue line), or NC5 (red line). (B) Survival of mice bearing PDX...
Published: 4/21/2024
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Inventor(s): Dongfang Liu, Xuening Wang
Keywords(s): Anti-cancer, Proteins
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
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Novel ChABC formulation with machine learning-guided automation
Invention Summary:
Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 4/21/2024
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Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
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Use of purified Epichloë festucae antifungal protein for dollar spot control on turfgrass
Invention Summary:
The dollar spot disease is a major challenge for turfgrass fields, especially golf courses. The commonly used solution to control this disease is fungicides, which can be hazardous and limited in effectiveness; thus, the need for an alternative solution is imminent.
Rutgers researchers in the department of...
Published: 4/25/2024
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Inventor(s): Faith Belanger, Bruce Clarke, Patrick Fardella
Keywords(s): Pest control, Proteins
Category(s): Technology Classifications > Agriculture, Technology Classifications > Ag Biotech
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A Novel Vaccine Candidate Against Fungal Infection
Vaccination with a heat-killed mutant strain combined with an adjuvant enhances protection against fungal infections in a murine model, significantly improving survival protection against WT H99 challenge. Above are a series of graphs that show vaccine efficacy using the combination vaccine in intranasal inhalation, subcutaneous injection, and intramuscular...
Published: 3/26/2024
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Inventor(s): Chaoyang Xue, Amariliz Rivera
Keywords(s): Proteins
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Vaccine
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Novel Computational Tool for Understanding Protein Interactions and Generating Energy Maps
Generation of the interior and exterior residues, which are predominantly hot and cold, respectively (red/salmon = high, white = middle, cyan/blue = low μ-factors), in a catalytic site of an enzyme using the novel computational model.
Invention Summary:
Most computational models rely on large numbers of weak interactions to describe protein...
Published: 1/19/2023
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Inventor(s): Lawrence Williams, Brian Schendt
Keywords(s): Proteins
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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High Efficiency Isotope Enriched Protein Production Systems
Isotopic Enrichment of Tryptic Fragments
Invention Summary:
Rutgers scientists have developed two Single Protein Production (SPP)-based systems to obtain high levels of specific isotopically enriched proteins: an independently inducible system (cSPP(tet)) and an amino acid auxotroph-based dual inducible system. The SPP system essentially turns living...
Published: 12/21/2023
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Inventor(s): Monica Roth, William Schneider, Gaetano Montelione, Masayori Inouye, Yeufeng Tang
Keywords(s): Proteins
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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A Novel Diagnostic Assay for Predicting Patients’ Resistance to mTOR Kinase Inhibitors
Invention Summary:
Mechanistic Target of Rapamycin (mTOR) is a highly conserved serine/thereonine protein kinase that plays a crucial role as part of two distinct kinase complexes, mTOR1C and mTOR2C, to regulate cell growth and metabolism. Abnormal activation of mTOR has been implicated in the pathogenesis of several cancers, type 2 diabetes, obesity,...
Published: 9/9/2022
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Inventor(s): Steven Zheng
Keywords(s): Proteins
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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