Search Results - yingxian+pan

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Specific inhibitors to mitigate mu opioid‐induced side‐effects without compromising analgesia

Preliminary data shows that the inhibitor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...

Published: 8/12/2025 | Inventor(s): Yingxian Pan

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Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications, Technology Classifications > Therapeutics

Biologic inhibitors to reduce adverse effects of traditional opioids without compromising analgesia

Invention Summary: Mu opioids, including morphine, fentanyl, and oxycodone, remain the mainstream drugs for moderate-to-severe pain management in the clinic despite their side-effects, such as tolerance, reward, addiction, and respiratory depression. However, misusing these mu opioids can magnify their side-effects and promote the development...

Published: 7/9/2025 | Inventor(s): Yingxian Pan

Keywords(s):

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics