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Expanding Human Primary Liver Tissues into Functional Organoids
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Invention Summary:
Chronic liver diseases account for approximately two million deaths per year- one million due to complications of cirrhosis and one million due to viral hepatitis and hepatocellular carcinoma. Unfortunately, there are few treatment options for these conditions, and they commonly require organ transplants. The primary...
Published: 12/16/2024
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Inventor(s): Hatim Sabaawy, Fredric Wondisford
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Human Normal and Cancer Organoid Culture with Defined Components for Six Different Tissue Types
Invention Summary:
An organoid is a small three-dimensional (3-D) cellular tissue structure that highly resembles the in-vivo organ from which it is originated. New technology developed at Rutgers Cancer Institute of New Jersey enables researchers to generate organoids from six different cancer types and normal tissues derived from patients suffering...
Published: 1/11/2024
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Inventor(s): Hatim Sabaawy, Monica Bartucci
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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Novel Array Insert for One-Step 3D Cultures and Histological Processing
Schematic diagram of the technology. Organoid cultures can be grown in a basket array the size of a 96-well plate. The array can be shrunk down to fit into a histology cassette without need to transfer the culture.
Invention Summary:
Organoids are multicellular 3D structures that faithfully mimic their in vivo organ counterparts and are valuable...
Published: 12/4/2024
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Inventor(s): Hatim Sabaawy, Howon Lee, Chen Yang, Daehoon Han
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools, Technology Classifications > Healthcare & Life Sciences
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