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GDA Inhibitors for the Treatment of Spinal Cord-Induced Neuropathic Pain
Invention Summary:
Spinal cord injury (SCI) and its associated chronic pain can significantly diminish quality of life. While therapies like spinal cord stimulation and neuromodulation offer potential pain relief, current pharmacological options fall short, often proving ineffective, short-lived, and laden with side effects, including addiction....
Published: 11/6/2024
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Inventor(s): Bonnie Firestein-Miller, Stella Elkabes
Keywords(s): Neurological disorder & neuropathic pain, Spinal Cord
Category(s): Technology Classifications > Therapeutics, Technology Classifications > CNS Disorder, Technology Classifications > Healthcare & Life Sciences
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Gsx1 GENE THERAPY TO TREAT SPINAL CORD INJURY
Gsx1 treatment promotes recovery of locomotion function in injured mice.
Invention Summary:
Spinal cord injury (SCI) can lead to permanent disruption of nervous system function. There is no effective treatment for promoting recovery of motor function after SCI currently available on the market. Previous research on SCI treatment focused on...
Published: 12/5/2024
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Inventor(s): Li Cai, Misaal Patel, Lisa Lyu
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy, Technology Classifications > CNS Disorder
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Novel ChABC formulation with machine learning-guided automation
Invention Summary:
Spinal cord injury (SCI) leads to the formation of scar tissue. The scarring leads to the toughening of the extracellular matrix, or the cellular environment. One of the major concerns of SCI is the prevention of neuronal connection recovery, which can lead to paralysis or reduced control of the nervous system. For...
Published: 6/13/2024
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Inventor(s): Adam Gormley, Matthew Tamasi, Shashank Kosuri, Michael Webb, Carlos Borca, Roshan Patel
Keywords(s): Biomaterials, Polymers & Composites, Proteins, Spinal Cord
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Software & Algorithms, Technology Classifications > Therapeutics
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MicroRNA-7 Gene Therapy Promotes Functional Recovery
Following Spinal Cord Injury
Following sever spinal cord compression, the AAV-miR-7 injected mice showed improved locomotor recovery, which is characterized by the Basso Mouse Scale (BMS).
Invention Summary:
Spinal cord injury (SCI) results in partial or complete loss of sensory or motor function. According to the National Spinal Cord Injury Statistical Center,...
Published: 10/21/2024
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Inventor(s): M. Maral Mouradian, Eunsung Junn, Myung-Sik Yoo
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
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New Cell Therapy Strategy for Treatment of Spinal Cord Injuries
Cell therapy strategy for spinal cord injuries and regenerative diseases.
Invention Summary:
Spinal cord injuries (SCI) are damages to the spinal cord neural tissues that cause sensory loss and motor paralysis. SCI patients have no options for curative therapy. Thus, a mild contusion to the spinal cord results in massive neuronal and glial cell...
Published: 8/31/2022
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Inventor(s): Hatem Sabaawy
Keywords(s): Spinal Cord, Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Novel Diagnostic Tool to Quantify Signatures of Movement in Subjects with Neurological Disorders, Autism and Autism Spectrum Disorders
Invention Summary:
Developmental disorders such as Autism, Autism Spectrum Disorders (ASD) and neurological disorders such as Parkinson’s disease are conditions that involve both cognitive and motor impairments. Currently there is a pressing need for tools that will help to measure objectively the severity of the person’s motor deficits,...
Published: 10/18/2024
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Inventor(s): Elizabeth Torres, Jorge Jose-Valenzuela
Keywords(s): Autism, Biosensor, Neurological disorder & neuropathic pain, Rehabilitation, Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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