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Efficient and Non-Genotoxic Gene Transfer System for Stem Cells
Comparison of efficiency and toxicity of transfection reagents carrying different amounts of DNA for mesenchymal stem cells (MSCs). These cells are primary cells and considered hard-to-transfect. Panel A shows the transfection efficiency of “Rutgers Transfection System” in comparison to the five most widely used commercially available reagents;...
Published: 5/22/2024
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Inventor(s): Arash Hatefi, Xuguang Chen, Alireza Nomani
Keywords(s): Stem Cells, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics
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New Cell Therapy Device for Isolating Cells and Exosomes
GMP-grade closed-system clinical cell therapy device for isolation and delivery of cells and exosomes.
Invention Summary:
Regenerative medicine research has become an important field of study due to the ability of regenerating cells to restore a wide variety of cell types. Regenerating cells can be isolated from multiple sources and can be used...
Published: 8/31/2022
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Inventor(s): Hatem Sabaawy
Keywords(s): Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices
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New Cell Therapy Strategy for Treatment of Spinal Cord Injuries
Cell therapy strategy for spinal cord injuries and regenerative diseases.
Invention Summary:
Spinal cord injuries (SCI) are damages to the spinal cord neural tissues that cause sensory loss and motor paralysis. SCI patients have no options for curative therapy. Thus, a mild contusion to the spinal cord results in massive neuronal and glial cell...
Published: 8/31/2022
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Inventor(s): Hatem Sabaawy
Keywords(s): Spinal Cord, Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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Personalized and Timed Release of Biomolecules
Invention Summary:
Protein/peptide-based therapeutics are powerful medications, however their use is often hampered by very short half-lives and the necessity for intravenous or subcutaneous injections.
Researchers from Rutgers University and Massachusetts General Hospital have developed a novel method to deliver protein/peptide-based therapeutics...
Published: 10/12/2022
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Inventor(s): Biju Parekkadan, Alexandra Burr, Alfred Tamayo
Keywords(s): Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Cell Therapy, Technology Classifications > Gene Therapy
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Cellular Reprogramming via Co-culture Bioreactor
Invention Summary:
Co-culture systems are a popular method for engineering complex multicellular systems. Specifically, for cell therapy, where one cell population can help differentiate another therapeutic cell population. Current co-culture methods have shown benefits, though there still remains a need for a scalable, integrated system that can...
Published: 5/15/2024
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Inventor(s): Biju Parekkadan
Keywords(s): Stem Cells
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices
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Stem Cell Growth Matrices with Enhanced Homogeneity, Stemness & Proliferation and Reduced Need for Feeding
Invention Summary:
There is currently no universal platform or widely accepted technique to efficiently and reproducibly grow stem and progenitor cells (SPCs) in vitro. Stem cells require contact with extracellular matrices as well as signals from growth factors to proliferate and to retain their stemness (preventing their differentiation towards progenitors)....
Published: 12/4/2024
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Inventor(s): Steven (steve) Levison, Nolan Skop, Frances Calderon, Cheul Cho, Chirag Gandhi
Keywords(s): Stem Cells, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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