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CHIR99021 Loaded Polymeric Scaffolds for the Treatment of Muscle Injuries
CHIR99021 administration reduces adipocyte differentiation (as seen by lipid droplet formation) in adipogenic cultures of stem cells. (A) Oil Red O staining for lipids 14 days after adipogenic induction. (B) Quantification of Oil Red O staining after 14 and 21 days.)
Invention Summary:
The most common injury among athletes are muscle injuries,...
Published: 3/25/2025
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Inventor(s): Doga Oruc, Joseph Freeman
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Three‐Dimensional, Load‐Sharing, Pre‐Vascularized
Scaffold for Bone Regeneration
Bi-weekly x-rays (A) showed progressive bone regeneration up to 10 weeks. The reconstructed CT images (B & C) show bone growing into and within the scaffold while the scaffolds maintained their mechanical strength.
Invention Summary:
Over 600,000 bone grafting procedures are performed in the US annually. While bone autografting is the gold...
Published: 12/11/2024
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Inventor(s): Joseph Freeman, Shreya Madhavarapu, Adhithi Lakshmikanthan
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Three-Dimensional Pre-Vascularized Scaffold
Schematic of load-bearing scaffold: osteonal cortical section, porous trabecular section, vascularized osteon, hydroxyapatite columns
Invention Summary:
This load-bearing scaffold mimics the native structure of cortical and trabecular bone to improve outcomes of orthopaedic surgeries. The biodegradable, polymeric scaffold has a porous trabecular...
Published: 10/6/2023
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Inventor(s): Joseph Freeman, Brittany Taylor, Tea Arapovic, Pushpendra Pankaj PATEL
Keywords(s): Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Medical Devices
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