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Biodegradable and Biocompatible Bioactive-based Polymers - Versatile Platform Technology
Invention Summary:
The Uhrich group has developed various biodegradable polymers that chemically incorporate bioactive molecules, such as nonsteroidal anti-inflammatory drugs (e.g., salicylic acid), antioxidants (e.g., ferulic acid) and antimicrobials (e.g., carvacrol). Bioactive molecules are incorporated into polymer backbones through labile linkages,...
Published: 4/17/2024
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Inventor(s): Kathryn Uhrich, Jonathan Faig, Kervin Smith
Keywords(s): Antibacterial, Bioengineering scaffolds, Biomaterials, Drug Delivery, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
S309-CAR cells show higher lysis of cells transfected with RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 8/22/2022
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Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > COVID-19
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Cellularized Nerve Regeneration Graft to Remediate Peripheral Nerve Injury
Invention Summary:
Peripheral Nerve Injuries (PNI) arising from physical trauma, cancers, or other nervous system pathologies are associated with higher costs and socioeconomic impact globally. Currently available technologies to remediate nerve injury are often unsuccessful in restoring nerve functions to its original capacity and cost of managing...
Published: 11/2/2022
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Inventor(s): Sanjeeva Murthy, Zhiping Pang, Jeremy Perrelle, Jasmine Gamboa, Andrew Boreland, Amir McCormick
Keywords(s): Bioengineering scaffolds, Biomaterials, Neuropathic Pain
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Healthcare & Life Sciences
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“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
CR3022-CAR cells have greater lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms are admitted into the ER have grim prognosis and have expensive limited treatment options. A large...
Published: 4/21/2024
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Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
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Rapid Cell Assembly for 3D Culture
A. Schematic diagram showing the self-assembly of a spheroid.
B. Schematic showing transplantation of spheroids for the repair/regeneration of spinal cord
Invention Summary:
3D cell culture including organoid and spheroid cultures is at the center stage of biomedical research. It is widely applied in organ development research, disease modeling,...
Published: 8/9/2023
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Inventor(s): Ki-Bum Lee, Christopher Rathnam, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
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Type-I Collagen Methacrylamide-Derivatized Hydrogels
Invention Summary:
Natural material collagen has the benefits of bioactivity, biodegradability, and innate adhesiveness and self-assemble, which allows the material to be injected into a defect of almost any geometry with minimal invasion, and then automatically become a solid to provide a stable matrix but have the limited control of mechanical properties....
Published: 9/8/2022
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Inventor(s): David Shreiber, Ian Gaudet
Keywords(s): Bioengineering scaffolds, Wound healing
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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CAR-T and CAR-NK Immunotherapy for Hepatocellular Carcinoma
CAR-NK cells control progression of HCC in PDX model
Invention Summary:
Chimeric antigen receptor (CAR)-modified T cell therapy has become a promising immune-therapeutic strategy for the treatment of various blood cancers. Hepatocellular carcinoma (HCC) is the most common type of cancer that starts in the liver. HCC is the third most common cause...
Published: 9/8/2022
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Inventor(s): Dongfang Liu
Keywords(s): Anti-cancer, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
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DNA Logic-gated Proximity Assembly Circuit for Biochemical Sensing
Schematic summary of the dNANOSIS assay
Invention Summary:
Point-of-Care (POC) testing is defined as a simple operated, easy-to-read, rapid, and low-cost medical diagnosis that can be used by non-specialists at home, in the field or in an ambulance. It provides timely diagnostic results, enabling early diagnosis of diseases, protective therapy and...
Published: 5/19/2023
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Inventor(s): Jinglin Fu, Sung Won Oh, Adriana Pereira
Keywords(s): Bioengineering scaffolds, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > COVID-19, Technology Classifications > Research Tools, Technology Classifications > Infectious Disease
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Scaffold-Free Biological Assemblies for Tissue Modeling and Regeneration
Invention Summary:
The evolution of in vitro-engineered scaffold-free tissues for tissue modeling and regenerative medicine has been driven by the need to recapitulate the cellular organization of endogenous tissues and to avoid undesired scaffold-related side effects upon implantation. Methods to produce scaffold-free tissue or cell assemblies have...
Published: 10/12/2022
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Tissue Engineering, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cell Therapy, Technology Classifications > Therapeutics
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Biodegradable Scaffold for Advanced Stem Cell Therapy
Schematic diagram representing the self assembly of Laminin (ECM) and the MnO2 sheet
Invention Summary:
While regenerative stem cell therapy has been a promising approach for transplant medicine and surgery, there have been challenges due to low transplantation survival rate and poor selectivity in differentiation.
Researchers at Rutgers University...
Published: 10/12/2022
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Inventor(s): Ki-Bum Lee, Letao Yang
Keywords(s): Bioengineering scaffolds, Biomaterials, Tissue Engineering
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials, Technology Classifications > Therapeutics
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