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MicroRNA Based Therapeutics for Parkinson’s Disease
Protection of the mouse brain by microRNA-7 against the toxicity of a-synuclein (A) Tyrosine hydroxylase (TH) stained coronal section of mouse brain injected in the right striatum with AAV-miR-7 or non-targeting (NT) vector following by a-synuclein preformed fibrils (PFF) or PBS. (B) Substantia nigra sections. (C) Nigral dopamine neuron count. (D) Striatal...
Published: 12/22/2021   |   Inventor(s): Mary Maral Mouradian, Eunsung Junn
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
MicroRNA-7 Gene Therapy Promotes Functional Recovery Following Spinal Cord Injury
Following sever spinal cord compression, the AAV-miR-7 injected mice showed improved locomotor recovery, which is characterized by the Basso Mouse Scale (BMS). Invention Summary: Spinal cord injury (SCI) results in partial or complete loss of sensory or motor function. According to the National Spinal Cord Injury Statistical Center,...
Published: 12/22/2021   |   Inventor(s): Mary Maral Mouradian, Eunsung Junn, Myung-Sik Yoo
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
Novel Gene Therapy to Treat L-DOPA-Induced Dyskinesia
Viral vector injections of rAAV-∆FosB shRNA significantly reduced abnormal involuntary movements (AIMs) compared to control vector in a rat model of Parkinson’s disease. Invention Summary: Parkinson's disease (PD) is a progressive, debilitating, and currently incurable neurodegenerative disease. Long-term dopamine replacement therapy in...
Published: 8/18/2020   |   Inventor(s): Mary Maral Mouradian, Stella Papa
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
Synergistic use of Coffee Components to Reduce Risk of Parkinson & other Neurodegenerative Diseases
Synergistic neuroprotection by two coffee components (EHT/Caffeine) to slow down progression of Parkinson’s Disease and Dementia with Lewy Bodies Invention Summary: Parkinson's disease (PD) is the second most common neurodegenerative disorder, and Dementia with Lewy bodies (DLB) is the second most common type of dementia after Alzheimer’s...
Published: 9/23/2019   |   Inventor(s): Mary Maral Mouradian, Jeffry Stock
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Food, Nutrition and Nutraceuticals