neurological+disorder+%26+neuropathic+pain - Available Technologies | Rutgers University Innovation Ventures

Search Results - neurological+disorder+%26+neuropathic+pain

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MicroRNA Based Therapeutics for Parkinson’s Disease
Protection of the mouse brain by microRNA-7 against the toxicity of a-synuclein (A) Tyrosine hydroxylase (TH) stained coronal section of mouse brain injected in the right striatum with AAV-miR-7 or non-targeting (NT) vector following by a-synuclein preformed fibrils (PFF) or PBS. (B) Substantia nigra sections. (C) Nigral dopamine neuron count. (D) Striatal...
Published: 12/22/2021   |   Inventor(s): Mary Maral Mouradian, Eunsung Junn
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Biodegradable and Versatile Copolymers to Promote Wound Healing
Invention Summary: Wound healing is a complex and dynamic process of replacing devitalized and missing cellular structures and tissue layers and thus there is a need for a biodegradable and versatile copolymers to promote wound healing. Rutgers scientists have developed a copolymer formulation to stably release salicylic acid (SA). It holds the promise...
Published: 12/1/2021   |   Inventor(s): Kathryn Uhrich, Sabrina Snyder
Keywords(s): Biomaterials, Drug Delivery, Neurological disorder & neuropathic pain, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Improved Nerve Conduits for Treatment of Peripheral Nerve Injuries
Scanning electron microscope image of conduits Invention Summary: Nerve conduits are used for treatment of peripheral nerve injuries. However, the current conduits are associated with poor healing resulting from swelling and reduction of luminal volume, suture pull-out, collapse, kinking, compression, and lack of mechanical strength to withstand...
Published: 11/11/2021   |   Inventor(s): Joachim Kohn
Keywords(s): Biomaterials, Neurological disorder & neuropathic pain, Polymers & Composites, Wound healing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Biomaterials
A Chemogenetic Therapy for Neuropathic Pain
Invention Summary: Neuropathic pain (NP) typically arises as a consequence of a lesion or disease affecting peripheral nerve fibers. Prominent features in the pathophysiology of neuropathic pain include increased, ectopic neuronal activity in pain pathways. In general, NP is frequently refractory to conventional analgesics and currently there are...
Published: 10/5/2021   |   Inventor(s): Gary Aston-Jones
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
Mobile Health Diagnostic for Schizophrenia
Invention Summary: Schizophrenia is a psychiatric disorder characterized by hallucinations, disorganized thought, delusions, and a decline in both mental and physical functioning. The disorder affects about 1% of the population. Early detection and treatment significantly improves patient response to treatment; and can prevent progression to full...
Published: 9/30/2021   |   Inventor(s): Thomas Papathomas, Attila Farkas
Keywords(s): Mental Health, Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Medical Devices, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
Sigma-1 Receptor Antagonists – Non-Addictive Pain Management
Invention Summary: The sigma 1 receptor (S1R), a molecular chaperone protein located in the endoplasmic reticulum and plasma membranes, plays important roles in various pathological disorders including pain. The potential commercial applications of novel S1R antagonists are twofold: 1) as stand-alone therapy for the treatment of chronic neuropathic...
Published: 7/9/2021   |   Inventor(s): William Welsh, Youyi Peng
Keywords(s): Antiviral, Neurological disorder & neuropathic pain, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Novel Gene Therapy to Treat L-DOPA-Induced Dyskinesia
Viral vector injections of rAAV-∆FosB shRNA significantly reduced abnormal involuntary movements (AIMs) compared to control vector in a rat model of Parkinson’s disease. Invention Summary: Parkinson's disease (PD) is a progressive, debilitating, and currently incurable neurodegenerative disease. Long-term dopamine replacement therapy in...
Published: 8/18/2020   |   Inventor(s): Mary Maral Mouradian, Stella Papa
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
Synergistic use of Coffee Components to Reduce Risk of Parkinson & other Neurodegenerative Diseases
Synergistic neuroprotection by two coffee components (EHT/Caffeine) to slow down progression of Parkinson’s Disease and Dementia with Lewy Bodies Invention Summary: Parkinson's disease (PD) is the second most common neurodegenerative disorder, and Dementia with Lewy bodies (DLB) is the second most common type of dementia after Alzheimer’s...
Published: 9/23/2019   |   Inventor(s): Mary Maral Mouradian, Jeffry Stock
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Food, Nutrition and Nutraceuticals
New Targeted Gene Therapy for Treatment of Duchenne Muscular Dystrophy
Invention Summary: Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy. It is a genetic disorder and patients suffering from DMD experience gradual muscle weakness in early childhood and are non-ambulant by 12 years of age. The progressive nature of this disease leads to restrictive pulmonary function, diaphragm...
Published: 6/13/2019   |   Inventor(s): Gopal Babu
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
An Injectable and Long-Acting Local Anesthetics
Invention Summary: Local anesthetics prevent or relieve pain by interrupting nerve conduction. Even the long-acting local anesthetic agents (e.g., bupivacaine, levobupivacaine, ropivacaine) can only provide analgesia for 4-18 hours. Because of the short duration, local anesthetics often have to be given by repeated injection or continuous infusion....
Published: 4/1/2019   |   Inventor(s): Yuanxiang Tao, Xiaoyang Xu
Keywords(s): Neurological disorder & neuropathic pain, Surgery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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