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Therapeutics for Drug-Resistant Bacterial Infections - Myxopyronins

Invention Summary: There is an urgent national and international need for new classes of antibacterial agents effective against bacterial pathogens resistant to current antibacterial agents. Myxopyronin (Myx) is a microbially produced antibiotic that inhibits bacterial RNA polymerase through a novel binding site and novel mechanism. Rutgers researchers...

Published: 10/18/2024 | Inventor(s): Richard Ebright, Juan Shen, James Bacci, William Solvible, Christopher Self, Gary Olson, Yon Ebright, Anne-Cecile Hiebel

Keywords(s): Antibacterial

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics

Therapeutics for Tuberculosis: Novel Inhibitors of Mycobacterial RNA Polymerase

Invention Summary: Tuberculosis kills nearly 2 million persons each year. One third of the world's population currently is infected with tuberculosis, and the World Health Organization projects that there will be nearly 1 billion new infections by 2020, 200 million of which will result in serious illness, and 35 million of which will result in...

Published: 12/4/2024 | Inventor(s): Richard Ebright, Yon Ebright, Soma Mandal

Keywords(s): Antibacterial

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics