Antioxidant-based poly(anhydride-esters) | Rutgers University Innovation Ventures

Antioxidant-based poly(anhydride-esters)

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Invention Summary:

Free radicals have been identified as major sources of oxidative stress in cells leading to DNA damage. This increased oxidative stress has been implicated in various deleterious conditions including cardiovascular diseases, neurodegenerative diseases, and cancer, while also contributing to the physiology of ageing. Antioxidants can counteract the oxidative stress; however, they are usually not in sufficient levels to overcome the damage from oxidative stress accumulation. Therefore, there has been much effort in the development of topical antioxidants with photoprotective and therapeutic efficacy.

Researchers at Rutgers University have designed a novel antioxidant composition with glycolic linkers. The antioxidants include p-coumaric acid, ferulic acid, and sinapic acid. These polymers can be fine-tuned for a desired antioxidant release profile, enhanced hydrophilicity, and other properties (thermal, mechanical, etc.) by altering the polymer chemical composition. The bioactive release rate can be altered for a tunable release delivery system, allowing for increased bioactive release. Overall, these tunable polymers could improve the quality, aesthetics, and performance of a product. 

Advantages:

  • End products with 100% purity of antioxidants
  • Stability of antioxidants in the product
  • Aesthetically more pleasing, as dark discoloration is mitigated

Market Applications:

  • Enhanced shelf-stability of personal care products against discoloring oxidation, including shampoo, lotion, skin products, and cosmetics
  • Topical drug delivery of antioxidants or other active agents in anti-ageing products

Intellectual Property & Development Status: Patent US9,862,672B2. Available for licensing and/or research collaboration.

Patent Information:
Contact:
Fred Banti
Associate Director, Life Sciences
Rutgers, The State University of New Jersey
848-932-4439
fb258@research.rutgers.edu
Keywords:
Biomaterials
Drug Delivery
Polymers & Composites