|
CAR-NK based combinatorial treatment for
drug-resistant tumors
Incucyte Killing Assay Images with AnnexinV cell death signal in MKI-Resistant HCC (Top panel). Chromium-51 release assays comparing GRP78 CAR-NK Killing to Naïve NK killing of various MKI-resistant tumor cell lines (bottom panels). Values shown are Means ± SEM. Significant p values indicated in red.
Invention Summary:
CAR-NK...
Published: 8/19/2024
|
Inventor(s): Dongfang Liu, Youssef Sabha, Chih-Hsiung Chen
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
|
|
Improving Object Detection and Instance Segmentation of Eukaryotic Cells Using Semantic Aware Data Augmentation
Invention Summary:
Machine Learning and Artificial Intelligence (AI)-Driven analysis have provided great advancements in microscopic imaging in the Biomedical field. The efficacy of many of these systems relies on the availability of many well-defined and empirically annotated images to serve as training data to teach such advanced...
Published: 5/15/2024
|
Inventor(s): Dongfang Liu, Alireza Naghizadeh
Keywords(s):
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms
|
|
DEVELOPMENT OF SPECIFIC CRK-LIKE ADAPTOR PROTEIN INHIBITORS FOR CANCER THERAPY
NC5 inhibits tumor growth and prolongs survival in vivo. NC5 treatment inhibits TNBC tumor growth and prolongs mice survival in xenograft and PDX mouse models. (A) Survival of mice bearing MDA-MB-231-Luc orthotopic xenograft tumors following treatment with vehicle (black line), Gleevec (blue line), or NC5 (red line). (B) Survival of mice bearing PDX...
Published: 10/29/2024
|
Inventor(s): Dongfang Liu, Xuening Wang, Jacques Roberge
Keywords(s): Anti-cancer, Proteins
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer
|
|
“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
S309-CAR cells show higher lysis of cells transfected with RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms who are admitted into the ER have grim prognosis and are sometimes faced with expensive and limited...
Published: 10/21/2024
|
Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > COVID-19
|
|
JobViz: User Interface for Visualization of Majors & Jobs
Invention Summary:
University (and industry) career search portals and web-based job search engines allow users to search on many items (e.g., education, location, level, etc.) and then present a text based list of potential job opportunities. University career portals are not as conductive to exploration by job and career searchers as they could...
Published: 9/8/2022
|
Inventor(s): Deborah Silver, Li Liu
Keywords(s):
Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms
|
|
“Off-the-shelf” CAR-NK cells for enhanced SARS-CoV-2 targeting in COVID-19 treatment
CR3022-CAR cells have greater lysis of cells transfected with the RBD of the SARS-CoV-2 spike protein compared to control.
Invention Summary:
COVID-19 remains a pandemic and a critical medical concern across the world. Patients with severe symptoms are admitted into the ER have grim prognosis and have expensive limited treatment options. A large...
Published: 10/21/2024
|
Inventor(s): Dongfang Liu, Minh Ma, Saiaditya Badeti
Keywords(s): Antiviral, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
|
|
CAR-T and CAR-NK Immunotherapy for Hepatocellular Carcinoma
CAR-NK cells control progression of HCC in PDX model
Invention Summary:
Chimeric antigen receptor (CAR)-modified T cell therapy has become a promising immune-therapeutic strategy for the treatment of various blood cancers. Hepatocellular carcinoma (HCC) is the most common type of cancer that starts in the liver. HCC is the third most common cause...
Published: 6/6/2024
|
Inventor(s): Dongfang Liu
Keywords(s): Anti-cancer, Bioengineering scaffolds
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer
|
|
A Novel Approach for Expansion of NK and CAR-modified NK Cells
Fold expansion of NK cells from cord blood expanded with irradiated K562-mIL21 and RU-Feeder Cells
Invention Summary:
Chimeric antigen receptor T-cell immunotherapy (CAR-T cell therapy) requires engineering of T cells harvested from the patient. Natural killer (NK) cells are also cytotoxic immune cells, but work somewhat differently from T cell....
Published: 6/6/2024
|
Inventor(s): Dongfang Liu
Keywords(s): Anti-cancer, Cell Lines
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cancer, Technology Classifications > Cell Therapy
|
