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Continuous Process for API Formulation and Manufacturing
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A comparison of dissolution profiles for impregnated ibuprofen (IBU) tablets and direct compression IBU tablets
Invention Summary:
A major challenge in pharmaceutical product development is the formation of homogenous blends containing small amount of active pharmaceutical ingredients (APIs). Poor...
Published: 10/12/2022
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Inventor(s): Fernando Muzzio, Benjamin Glasser, Thamer Omar
Keywords(s): Chemical and petrochemical industry, Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Continuous Process for API Formulation and Manufacturing
A comparison of dissolution profiles for impregnated ibuprofen (IBU) tablets and direct compression IBU tablets
Invention Summary:
A major challenge in pharmaceutical product development is the formation of homogenous blends containing small amount of active pharmaceutical ingredients (APIs). Poor mechanical...
Published: 9/1/2023
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Inventor(s): Fernando Muzzio
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering
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Continuous Melt-Coating for Improving API Solubility and Loading
Invention Summary:
Poor solubility is a major obstacle to bringing a drug candidate into the market. Existing methods including micronization, amorphization, spray drying and hot melt extrusion that aim to improve solubility are expensive, difficult to implement, and associated with problems such as instability, limitation in drug loading....
Published: 6/6/2023
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Inventor(s): Fernando Muzzio, Zhanjie Liu, Gerardo Callegari, Douglas Hausner
Keywords(s): Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Formulation and Manufacture of Pharmaceuticals by Impregnation onto Porous Carriers
Figure 1. SEM Pictures of pure Neusilin® and impregnated with Fenofibrate at 30% loading.
Invention Summary:
Rutgers scientists have developed a novel platform of pharmaceutical product development by utilizing fluid bed impregnation (FBI) of API solutions onto porous carriers. Impregnation of solutions into porous carriers allows extremely uniform...
Published: 9/8/2022
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Inventor(s): Fernando Muzzio, Benjamin Glasser, Plamen Grigorov
Keywords(s):
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials
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