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Continuous Process for API Formulation and Manufacturing
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A comparison of dissolution profiles for impregnated ibuprofen (IBU) tablets and direct compression IBU tablets
Invention Summary:
A major challenge in pharmaceutical product development is the formation of homogenous blends containing small amount of active pharmaceutical ingredients (APIs). Poor...
Published: 10/12/2022
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Inventor(s): Fernando Muzzio, Benjamin Glasser, Thamer Omar
Keywords(s): Chemical and petrochemical industry, Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Continuous Melt-Coating for Improving API Solubility and Loading
Invention Summary:
Poor solubility is a major obstacle to bringing a drug candidate into the market. Existing methods including micronization, amorphization, spray drying and hot melt extrusion that aim to improve solubility are expensive, difficult to implement, and associated with problems such as instability, limitation in drug loading....
Published: 6/6/2023
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Inventor(s): Fernando Muzzio, Zhanjie Liu, Gerardo Callegari, Douglas Hausner
Keywords(s): Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
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Multiplexed 3D printing
Invention Summary:
Motivation: Extrusion-based 3D printing of polymer- or polymer-composite parts can realize new applications in metamaterials, batteries, energy, and robotics.
Limitations of existing printing methods: Current extrusion-based 3D printing methods increase throughput by increasing line width and thus cannot resolve complex features...
Published: 6/13/2024
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Inventor(s): Rajiv Malhotra, Jeremy Cleeman, Alex Bogut
Keywords(s): Machines & Instruments, Manufacturing, Polymers & Composites
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Software & Algorithms
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Post-Print Physical Vetting of 3D Prints with Minimal Embedded Nano-Material Assessor
Overview of the Model System
Invention Summary:
3D printing has become highly desirable in industrial manufacturing and biomedical applications. Outsourcing the manufacturing to a 3D printing facility leaves the user without access to the printers and a lack of physical verification to determine whether small defects, invisible to the naked eye,...
Published: 3/17/2023
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Inventor(s): Saman Aliari Zonouz, Mehdi Javanmard, Abdul Beyah, Luis Garcia, Tuan-Anh Le, Christian Bayens
Keywords(s): Machines & Instruments, Manufacturing, Sensors & Probes
Category(s): Technology Classifications > Physical Sciences & Engineering
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Novel System for High-Yield Production of Proteins and Protein Domains
Invention Summary:
The synthesis of recombinant proteins using prokaryotic expression systems has been instrumental in producing valuable reagents for biomedical research and commercial products. However, the majority of in vivo expression systems have inherent limitations in most applications – including low yields, poor quality of the expressed...
Published: 7/16/2024
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Inventor(s): Gaetano Montelione, Stephen Anderson, Yuanpeng Huang, Thomas Acton
Keywords(s): Drug Discovery/Screening, Manufacturing, Peptides
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
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Method for Sintering Ultrahigh Melting Temperature Covalent Non-oxide Ceramics
Parallel plate capacitor configuration used to apply an electric field and to achieve low-temperature sintering of a non-oxide ceramic (B4C)
Invention Summary:
Bulk and composite structural ceramics can be fabricated by sintering, forming particulate matter into a desired shape and then subjecting the formed body to high temperatures (2/3 of the...
Published: 12/4/2024
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Inventor(s): Thomas Tsakalakos, Enver Akdoğan, Ilyas Savkliyildiz, Hulya Bicer, William Paxton, Bart Visser, Lawrence Kabacoff
Keywords(s): Glass & Ceramics, Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials
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Scalable Multiple Inverse-Diffusion Flame Synthesis of Graphene, Syngas and Liquid Fuel & Fabrication of Diamond-Reinforced Composites
A) A schematic multiple inverse-diffusion flames burner. B) Raman spectrum of the few-layer graphene (FLG) on Ni. C) HRTEM image of the FLG. The bottom right insert shows the electron diffraction pattern of the graphene sheet. The top left insert shows resolution magnified image of the graphitic lattice.
Invention Summary:
Carbon-based nanostructures...
Published: 6/13/2024
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Inventor(s): Bernard Kear, Stephen Tse, Nasir Memon
Keywords(s): Graphene technology, Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials
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Coating with Self-Limiting Electrospray Deposition
Invention Summary:
Researchers at Rutgers University have developed a scalable technique for depositing microscale coatings of a wide variety of materials and composites onto complex 3D additive or micromachined structures. The new coating process, based on self-limiting electrospray deposition (SLED), once deposited on the surface of a target material,...
Published: 9/12/2024
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Inventor(s): Jonathan Singer, Howon Lee
Keywords(s): Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering
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Damage Resistant Glass-Ceramic
This material has better hardness and crack resistance than any commercially available glass
Invention Summary:
Rutgers University researchers have developed an Al2O3 rich damage resistant glasses and glass-ceramics, which exhibit Vickers hardness of >7 GPa and do not crack at loads as high as 2000 gf (19.6 N).
The resistance to fracture is...
Published: 6/13/2024
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Inventor(s): Ashutosh Goel
Keywords(s): Glass & Ceramics, Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering
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Continuous Sheet Folding Machine with Microfolding Technology
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Invention Summary:
Folded materials are useful in packaging, sandwich structures, floor boards, car bumpers and other applications where requirements pertaining to shock, vibration, energy absorption, and/or a high strength-to-weight ratio including volume reduction must be met. Folding flat sheets of material...
Published: 4/26/2024
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Inventor(s): Elsayed Elsayed, Dan Kling, Basily Basily
Keywords(s): Machines & Instruments, Manufacturing
Category(s): Technology Classifications > Physical Sciences & Engineering
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